Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Consequences of Cell Death

2000 • 1,382 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

2001 • 1,122 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

2000 • 733 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Macropinocytosis

1995 • 706 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.

1999 • 635 citations

Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts

2001 • 633 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans

2001 • 591 citations

The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography

1977 • 566 citations

The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids

1995 • 546 citations

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

2000 • 529 citations

A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.

1985 • 517 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]

1989 • 448 citations

Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria

1993 • 443 citations

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 • 440 citations

Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro

1995 • 435 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

1998 • 385 citations

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

2000 • 375 citations

The coated pit and macropinocytic pathways serve distinct endosome populations

1994 • 374 citations

Apoptosis: The importance of being eaten

1998 • 349 citations

Scavenger receptors in innate immunity

1996 • 325 citations

The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68.

1995 • 310 citations

Requirement of CDC42 for Salmonella -Induced Cytoskeletal and Nuclear Responses

1996 • 303 citations

Complement dependent immune phagocytosis

1968 • 295 citations

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

1995 • 293 citations

Action of highly purified phospholipases on blood platelets. Evidence for an asymmetric distribution of phospholipids in the surface membrane

1977 • 248 citations

Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages.

1989 • 242 citations

Phorbol esters stimulate macropinocytosis and solute flow through macrophages

1989 • 240 citations

Promotion of the Uptake of PS Liposomes and Apoptotic Cells by a Product of Growth Arrest-Specific Gene, gas6

2000 • 224 citations

Involvement of the epidermal growth factor receptor in the invasion of cultured mammalian cells by Salmonella typhimurium

1992 • 224 citations

Differences between the clearance of apoptotic cells by professional and non-professional phagocytes

2000 • 214 citations

Surfactant Protein A Enhances Alveolar Macrophage Phagocytosis of Apoptotic Neutrophils

2001 • 209 citations

Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline

1999 • 190 citations

M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages

1992 • 188 citations

Distinct Modes of Macrophage Recognition for Apoptotic and Necrotic Cells Are Not Specified Exclusively by Phosphatidylserine Exposure

2001 • 177 citations

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

2000 • 173 citations

Influence of epidermal growth factor (EGF) on ruffling activity, pinocytosis and proliferation of cultivated human glia cells

1976 • 165 citations

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

2001 • 160 citations

Role of Class B Scavenger Receptor Type I in Phagocytosis of Apoptotic Rat Spermatogenic Cells by Sertoli Cells

1999 • 153 citations

Membrane traffic during cell locomotion

1998 • 149 citations

Immune Clearance of Phosphatidylserine-expressing Cells by Phagocytes

1997 • 148 citations

Characterization of Phosphatidylserine-dependent β2-Glycoprotein I Macrophage Interactions

1998 • 146 citations

Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells.

1993 • 145 citations

Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes

1999 • 138 citations

Multiple systems for recognition of apoptotic lymphocytes by macrophages.

1997 • 133 citations

Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved

1998 • 131 citations

Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/macrophage‐specific monoclonal antibody

1994 • 118 citations

The Molecular Mechanism of Programmed Cell Death in C. elegans

1999 • 103 citations

Conversion of phosphatidylcholine to phosphatidylserine by various phospholipases D in the presence of l- or d-serine

1989 • 101 citations

Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils

1996 • 96 citations

Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction

1997 • 85 citations

Altered lipid packing identifies apoptotic thymocytes

1993 • 77 citations

An assay for the quantitative measurement of in vitro phagocytosis of early apoptotic thymocytes by murine resident peritoneal macrophages

1999 • 48 citations

Independent Mechanisms for Macrophage Binding and Macrophage Phagocytosis of Damaged Erythrocytes

1997 • 44 citations