Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 • 2,766 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

The specificities of protein kinase inhibitors: an update

2003 • 1,345 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

2002 • 741 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

1998 • 692 citations

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

2000 • 664 citations

mDia mediates Rho-regulated formation and orientation of stable microtubules

2001 • 566 citations

CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration

2001 • 558 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases

2002 • 444 citations

Cadherin Engagement Regulates Rho family GTPases

2001 • 421 citations

CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans

2000 • 410 citations

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

2002 • 375 citations

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

2000 • 375 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

2001 • 357 citations

Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases

2003 • 334 citations

Function of Rho family proteins in actin dynamics during phagocytosis and engulfment

2000 • 326 citations

Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3

2000 • 325 citations

Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans

2001 • 309 citations

A contractile activity that closes phagosomes in macrophages

1999 • 279 citations

Rho-kinase as a Novel Therapeutic Target in Treatment of Cardiovascular Diseases

2002 • 264 citations

Fc receptor-mediated phagocytosis requires CDC42 and Rac1

1998 • 254 citations

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

1998 • 243 citations

Role of Rho family GTPases in epithelial morphogenesis

2002 • 238 citations

Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts

2001 • 236 citations

Rho-Kinase and Myosin-II Control Phagocytic Cup Formation during CR, but Not FcγR, Phagocytosis

2002 • 232 citations

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

2002 • 212 citations

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

2000 • 199 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

C. elegans CED-12 Acts in the Conserved CrkII/DOCK180/Rac Pathway to Control Cell Migration and Cell Corpse Engulfment

2001 • 165 citations

Cadherin Engagement Inhibits RhoA via p190RhoGAP

2003 • 164 citations

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

2001 • 160 citations

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

1989 • 137 citations

Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion.

1997 • 131 citations

Role of Rho-Associated Kinase in Neointima Formation After Vascular Injury

2001 • 131 citations

Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells

2001 • 125 citations

Different Regions of Rho Determine Rho-selective Binding of Different Classes of Rho Target Molecules

1998 • 119 citations

Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase

2000 • 118 citations

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

2001 • 106 citations

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

2001 • 96 citations

Advances in Rho-dependent actin regulation and oncogenic transformation

2002 • 89 citations

Apoptosis: Getting rid of the bodies

1998 • 86 citations

Activation of the Lbc Rho Exchange Factor Proto-Oncogene by Truncation of an Extended C Terminus That Regulates Transformation and Targeting

1999 • 84 citations

The Function of the p190 Rho GTPase-activating Protein Is Controlled by Its N-terminal GTP Binding Domain

1998 • 83 citations

Evidence for a Conserved Role for CrkII and Rac in Engulfment of Apoptotic Cells

2001 • 79 citations

Advances in Cytokinesis Research. Role of Myosin Light Chain Phosphorylation in the Regulation of Cytokinesis.

2001 • 60 citations

Bacterial toxins modifying the actin cytoskeleton.

1999 • 59 citations

Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins

2001 • 45 citations

Diversity in phagocytic signalling

2001 • 39 citations