Rho GDP Dissociation Inhibitor Protects Cancer Cells against Drug-Induced Apoptosis

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Rho GTPases are over-expressed in human tumors

1999 • 667 citations

Rho Guanine Dissociation Inhibitors

1999 • 487 citations

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

2002 • 361 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer

2002 • 291 citations

Current status of the molecular mechanisms of anticancer drug-induced apoptosis

2002 • 252 citations

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα

1999 • 205 citations

The Rho Small G Protein Family-Rho GDI System as a Temporal and Spatial Determinant for Cytoskeletal Control

1998 • 200 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Crystal Structure of the Rac1−RhoGDI Complex Involved in NADPH Oxidase Activation^,

2001 • 135 citations

Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.

1993 • 123 citations

Activation of the RacGTPase inhibits apoptosis in human tumor cells

2001 • 123 citations

Proteomics of breast cancer for marker discovery and signal pathway profiling

2001 • 120 citations

Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis

2000 • 116 citations

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation

2002 • 105 citations

RhoGDIγ: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

1997 • 102 citations

Mechanism of NADPH Oxidase Activation by the Rac/Rho-GDI Complex

2001 • 92 citations

RhoGDI Is Required for Cdc42-Mediated Cellular Transformation

2003 • 84 citations

Cdc42 Is a Substrate for Caspases and Influences Fas-induced Apoptosis

2001 • 72 citations

The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages.

1994 • 68 citations

Rac1 Inhibits Apoptosis in Human Lymphoma Cells by Stimulating Bad Phosphorylation on Ser-75

2004 • 67 citations

Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI

2002 • 64 citations

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI

2001 • 64 citations

Oligomerization of Rac1 GTPase Mediated by the Carboxyl-terminal Polybasic Domain

2001 • 52 citations

Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

2000 • 50 citations

Involvement of Rho and Rac small G proteins and Rho GDI in Ca²⁺‐dependent exocytosis from PC12 cells

1996 • 50 citations

Involvement of rho p21 and Its Inhibitory GDP/GTP Exchange Protein (rho GDI) in Cell Motility

1993 • 46 citations

Study of Therapy Resistance in Cancer Cells with Functional Proteome Analysis

2002 • 46 citations

Caspase 3-Mediated Inactivation of Rac GTPases Promotes Drug-Induced Apoptosis in Human Lymphoma Cells

2003 • 43 citations

Proteomic analysis of apoptosis initiation induced byall-trans retinoic acid in human acute promyelocytic leukemia cells

2001 • 43 citations

An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells

2004 • 37 citations

Maintenance of Cdc42 GDP-bound State by Rho-GDI Inhibits MAP Kinase Activation by the Exchange Factor Ras-GRF

2001 • 34 citations