Influence of drug‐induced apoptotic death on processing and presentation of tumor antigens by dendritic cells

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

Consequences of Cell Death

2000 • 1,382 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

1995 • 324 citations

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

1999 • 301 citations

Human tumor antigens for cancer vaccine development

1999 • 298 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Cancer Tumor antigens

1997 • 289 citations

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease

2000 • 258 citations

Dendritic Cells Capture Killed Tumor Cells and Present Their Antigens to Elicit Tumor-Specific Immune Responses

2000 • 237 citations

Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.

2000 • 222 citations

Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization.

2001 • 202 citations

Dendritic cells resurrect antigens from dead cells

2001 • 192 citations

Establishment of cultured cell lines derived from a human gastric carcinoma.

1978 • 185 citations

Dendritic cell-based immunotherapy of prostate cancer: immune monitoring of a phase II clinical trial.

2000 • 164 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

Cutting Edge: Differential Effect of Apoptotic Versus Necrotic Tumor Cells on Macrophage Antitumor Activities

1999 • 142 citations

The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor α spots in response to peptide antigens

1997 • 142 citations

Antigen-presenting cells that phagocytose apoptotic tumor-derived cells are potent tumor vaccines.

1999 • 133 citations

Adjuvant active specific immunotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized phase III trials show promise

2001 • 133 citations

Phases of apoptosis of melanoma cells, but not of normal melanocytes, differently affect maturation of myeloid dendritic cells.

2001 • 76 citations

Cell death and cancer therapy

2001 • 68 citations

Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: comparison of bolus administration and continuous infusion

1993 • 61 citations

Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit

1993 • 59 citations

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

1999 • 49 citations

Dr. Josef Steiner Cancer Research Prize Lecture: The role of physiological cell death in neoplastic transformation and in anti-cancer therapy

1999 • 20 citations

Ex Vivo Host Response to Gastrointestinal Cancer Cells Presented by Autologous Dendritic Cells

2001 • 15 citations

Immunotherapy for colorectal cancer

2001 • 13 citations

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