Function and regulation of Rnd proteins

Prediction of central nervous system embryonal tumour outcome based on gene expression

2002 • 2,359 citations

ROCKs: multifunctional kinases in cell behaviour

2003 • 1,866 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides

1998 • 784 citations

Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle

2000 • 599 citations

Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation

2003 • 532 citations

Semaphorins command cells to move

2005 • 473 citations

An ECT2–centralspindlin complex regulates the localization and function of RhoA

2005 • 470 citations

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras

2004 • 371 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

RAS and RHO GTPases in G1-phase cell-cycle regulation

2004 • 346 citations

RhoE Binds to ROCK I and Inhibits Downstream Signaling

2003 • 300 citations

CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell Invasion

2002 • 284 citations

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.

1996 • 272 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

2001 • 245 citations

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

2003 • 237 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

Regulating Axon Branch Stability

2001 • 207 citations

The semaphorin 3A receptor may directly regulate the activity of small GTPases

2000 • 177 citations

Binding of Factor VIIa to Tissue Factor on Keratinocytes Induces Gene Expression

2000 • 177 citations

Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells.

2003 • 174 citations

Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers.

2003 • 166 citations

A pancreatic cancer-specific expression profile.

1996 • 160 citations

Antagonistic Effects of Rnd1 and RhoD GTPases Regulate Receptor Activity in Semaphorin 3A-Induced Cytoskeletal Collapse

2002 • 158 citations

RhoE function is regulated by ROCK I-mediated phosphorylation

2005 • 157 citations

Discovery of Aberrant Expression of R-RAS by Cancer-Linked DNA Hypomethylation in Gastric Cancer Using Microarrays

2005 • 156 citations

The Rho GTPase family: a Racs to Wrchs story

2002 • 142 citations

Phosphorylation of Serine 188 Protects RhoA from Ubiquitin/Proteasome-Mediated Degradation in Vascular Smooth Muscle Cells

2005 • 142 citations

ARAP3 Is a PI3K- and Rap-Regulated GAP for RhoA

2004 • 121 citations

Direct Interaction of Rnd1 with Plexin-B1 Regulates PDZ-RhoGEF-mediated Rho Activation by Plexin-B1 and Induces Cell Contraction in COS-7 Cells

2003 • 120 citations

Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development

1999 • 118 citations

Plexin signaling hampers integrin‐based adhesion, leading to Rho‐kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility

2004 • 116 citations

RhoE Inhibits Cell Cycle Progression and Ras-Induced Transformation

2004 • 115 citations

Induced Expression of Rnd3 Is Associated with Transformation of Polarized Epithelial Cells by the Raf–MEK–Extracellular Signal-Regulated Kinase Pathway

2000 • 104 citations

Identification of metastasis-associated genes in prostate cancer by genetic profiling of human prostate cancer cell lines.

2005 • 102 citations

Rapostlin Is a Novel Effector of Rnd2 GTPase Inducing Neurite Branching

2002 • 88 citations

EphB1 Associates with Grb7 and Regulates Cell Migration

2002 • 79 citations

Small G‐protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis

2005 • 79 citations

A novel gene family induced by acute inflammation in endothelial cells

2004 • 76 citations

A Role of Rnd1 GTPase in Dendritic Spine Formation in Hippocampal Neurons

2003 • 76 citations

Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers

2002 • 75 citations

Expression profiling of cancer-related genes in human keratinocytes following non-lethal ultraviolet B irradiation

2001 • 75 citations

The Rho‐related protein Rnd1 inhibits Ca²⁺ sensitization of rat smooth muscle

1999 • 65 citations

Gene expression profiling and subgroup identification of oligodendrogliomas

2004 • 57 citations

Direct Interaction of Rnd1 with FRS2β Regulates Rnd1-induced Down-regulation of RhoA Activity and Is Involved in Fibroblast Growth Factor-induced Neurite Outgrowth in PC12 Cells

2005 • 53 citations

Modulation of RhoA-Rho kinase-mediated Ca2+ sensitization of rabbit myometrium during pregnancy - role of Rnd3

2003 • 46 citations

Differential Gene Expression Patterns by Oligonucleotide Microarray of Basal versus Lipopolysaccharide-Activated Monocytes from Cord Blood versus Adult Peripheral Blood

2004 • 44 citations

Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells

2003 • 40 citations

Rnd1, a Novel Rho Family GTPase, Induces the Formation of Neuritic Processes in PC12 Cells

2000 • 37 citations

Crystal structure of Rnd3/RhoE: functional implications¹

2002 • 37 citations

Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac

2000 • 34 citations

Identification of Splicing Variants of Rapostlin, a Novel Rnd2 Effector that Interacts with Neural Wiskott-Aldrich Syndrome Protein and Induces Neurite Branching

2004 • 33 citations

RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells

1999 • 31 citations

Identification of genes involved in estrogenic action in the human prostate using microarray analysis

2003 • 30 citations

GTPase Regulation Getting aRnd Rock and Rho Inhibition

2003 • 29 citations

Role of Rho kinase signalling in healthy and varicose human saphenous veins

2002 • 25 citations

Crystal Structure of the Core Domain of RhoE/Rnd3: A Constitutively Activated Small G Protein^,

2002 • 25 citations

Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family

2000 • 25 citations

Ascidians as a vertebrate‐like model organism for physiological studies of Rho GTPase signaling

2003 • 25 citations

Simultaneous Suppression of Progression Marker Genes in the Highly Malignant Human Melanoma Cell Line BLM after Transfection with the Adenovirus-5 E1A Gene

1996 • 24 citations

Rnd3/RhoE induces tight junction formation in mammary epithelial tumor cells

2005 • 24 citations

Expression analysis of neuroleukin, calmodulin, cortactin, and Rho7/Rnd2 in the intact and injured mouse brain

2005 • 23 citations

Up-regulation of Rnd1 during pregnancy serves as a negative-feedback control for Ca2+ sensitization of contractile elements in rat myometrium

2003 • 21 citations

Difference in gene expression profile in breast epithelial cells from women with different reproductive history

2003 • 13 citations