Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Mechanisms of Cancer Drug Resistance

2002 • 2,495 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

2002 • 845 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Cross-presentation in viral immunity and self-tolerance

2001 • 460 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 427 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 394 citations

Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases

2001 • 371 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Tumor-Specific CD4+ T Cells Have a Major “Post-Licensing” Role in CTL Mediated Anti-Tumor Immunity

2000 • 337 citations

Apoptosis and cancer chemotherapy

2001 • 296 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

Gemcitabine exerts a selective effect on the humoral immune response: implications for combination chemo-immunotherapy.

2002 • 235 citations

Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.

2000 • 222 citations

Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization.

2001 • 202 citations

Combined intraarterial 5‐fluorouracil and subcutaneous interferon‐α therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches

2002 • 202 citations

Establishment of a murine model of malignant mesothelioma

1992 • 184 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

Tumor Antigens are Constitutively Presented in the Draining Lymph Nodes

1999 • 170 citations

Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity

2000 • 153 citations

Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

2002 • 151 citations

Cutting Edge: Differential Effect of Apoptotic Versus Necrotic Tumor Cells on Macrophage Antitumor Activities

1999 • 142 citations

Schedule-dependent antitumor effect of gemcitabine in in vivo model system.

1995 • 140 citations

On cross-priming of MHC class I-specific CTL: rule or exception?

2002 • 135 citations

T-cell receptor transgenic analysis of tumor-specific CD8 and CD4 responses in the eradication of solid tumors.

1999 • 124 citations

The dendritic cell and human cancer vaccines

2000 • 123 citations

Apoptosis and cancer chemotherapy

2001 • 94 citations

Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells

1999 • 86 citations

Dead or alive: immunogenicity of human melanoma cells when presented by dendritic cells.

2000 • 85 citations

Tumor Progression Despite Efficient Tumor Antigen Cross-Presentation and Effective “Arming” of Tumor Antigen-Specific CTL

2001 • 68 citations

Pegylated liposomal tumor necrosis factor‐α results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil®) in soft tissue sarcoma‐bearing rats

2001 • 63 citations

Prospective Randomized Comparison of Dacarbazine (DTIC) Versus DTIC Plus Interferon-Alpha (IFN-α) in Metastatic Melanoma

2001 • 63 citations

Apoptosis and anticancer drug resistance.

2001 • 54 citations

A phase II study of neoadjuvant biochemotherapy for stage III melanoma

2002 • 52 citations

Targeting apoptosis in cancer chemotherapy

2002 • 44 citations

7-Hydroxystaurosporine-induced Apoptosis in 9L Glioma Cells Provides an Effective Antigen Source for Dendritic Cells and Yields a Potent Vaccine Strategy in an Intracranial Glioma Model

2002 • 29 citations

Carboplatin/etoposide/radiation plus escalating doses of paclitaxel in stage III non-small cell lung cancer: A preliminary report

1996 • 27 citations

Dendritic Cell–Dead Cell Interactions: Implications and Relevance for Immunotherapy

2001 • 24 citations

Intrathymic deletion of MHC class I-restricted cytotoxic T cell precursors by constitutive cross-presentation of exogenous antigen

1999 • 22 citations

Role of Antigen-Presenting Cells in Long-Term Antitumor Response Based on Tumor-Derived Apoptotic Body Vaccination

1999 • 19 citations

Gemcitabine induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells

1998 • 19 citations

Enhancement of heat-induced heat shock protein (hsp)72 accumulation by doxorubicin (Dox) in vitro

2000 • 16 citations

Strategies for Combining Chemotherapy and Biotherapy in Melanoma

2000 • 15 citations

7-Hydroxystaurosporine-induced Apoptosis in 9L Glioma Cells Provides an Effective Antigen Source for Dendritic Cells and Yields a Potent Vaccine Strategy in an Intracranial Glioma Model

2002 • 6 citations

Low doses of chemotherapy to inhibit suppressor T cells.

1989 • 4 citations

Prospective Randomized Comparison of Dacarbazine (DTIC) Versus DTIC Plus Interferon-Alpha (IFN-α) in Metastatic Melanoma

2001 • 4 citations

Lymphocyte activation and effector functions

2002 • 1 citations