Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

1994 • 1,564 citations

A second endogenous cannabinoid that modulates long-term potentiation

1997 • 1,474 citations

Membrane lipid composition and cellular function.

1985 • 1,439 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Basic Neurochemistry???Molecular, Cellular, and Medical Aspects

2006 • 1,374 citations

Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

1989 • 1,360 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Free Radicals and Antioxidants: A Personal View

2009 • 1,095 citations

HEALTH BENEFITS OF DOCOSAHEXAENOIC ACID (DHA)

1999 • 997 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement

1993 • 831 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Myelination in the Absence of Galactocerebroside and Sulfatide: Normal Structure with Abnormal Function and Regional Instability

1996 • 601 citations

Cytolytic and membrane-perturbing properties of lysophosphatidylcholine

1979 • 594 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

THE STRUCTURE AND BIOSYNTHESIS OF GLYCOSYL PHOSPHATIDYLINOSITOL PROTEIN ANCHORS

1993 • 585 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy

1995 • 532 citations

Cytosolic phospholipase A2

1995 • 530 citations

The glycosyl-phosphatidylinositol anchor of membrane proteins

1989 • 520 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Lipid regulation of cell membrane structure and function

1989 • 492 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

Pharmacology of Cannabinoid Receptors

1995 • 485 citations

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.

1993 • 469 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

N-Acylated glycerophospholipids and their derivatives

1990 • 445 citations

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

1997 • 435 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

Early Detection of Apoptosis Using a Fluorescent Conjugate of Annexin V

1997 • 376 citations

Advances in Cyclic Nucleotide and Protein Phosphorylation Research

1975 • 373 citations

Regulation of phospholipase D

1999 • 369 citations

Biochemistry of Lipids, Lipoproteins and Membranes

1996 • 352 citations

A possible role for plasmalogens in protecting animal cells against photosensitized killing.

1988 • 344 citations

Phospholipase A₂ and Its Role in Brain Tissue

1997 • 337 citations

‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance

1998 • 317 citations

Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor

1999 • 306 citations

Partial Purification and Characterization of the Porcine Brain Enzyme Hydrolyzing and Synthesizing Anandamide

1995 • 305 citations

Acyltransferases and Transacylases Involved in Fatty Acid Remodeling of Phospholipids and Metabolism of Bioactive Lipids in Mammalian Cells

1997 • 293 citations

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

1991 • 286 citations

Arachidonic acid as a neurotoxic and neurotrophic substance

1995 • 275 citations

Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor

1993 • 253 citations

Exposure of Phosphatidylethanolamine on the Surface of Apoptotic Cells

1997 • 247 citations

Occurrence and postmortem generation of anandamide and other long‐chain N‐acylethanolamines in mammalian brain

1995 • 233 citations

Positive regulation of mu-calpain action by polyphosphoinositides.

1992 • 231 citations

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

1995 • 230 citations

Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type.

1983 • 223 citations

Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis Possible candidate genes

1999 • 222 citations

Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease

1999 • 220 citations

Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors

1999 • 216 citations

CTP:phosphocholine cytidylyltransferase

1997 • 215 citations

Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain

1996 • 211 citations

Transacylase‐Mediated and Phosphodiesterase‐Mediated Synthesis of N‐Arachidonoylethanolamine, an Endogenous Cannabinoid‐Receptor Ligand, in Rat Brain Microsomes

1996 • 209 citations

Ether lipids in biomembranes

1994 • 201 citations

Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains

1987 • 201 citations

Phosphatidylethanolamine N-methyltransferase from liver

1997 • 195 citations

Properties of rat liver N-acylethanolamine amidohydrolase.

1985 • 194 citations

GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids.

1994 • 192 citations

Platelet-activating factor: the biosynthetic and catabolic enzymes

1995 • 188 citations

A family of phospholipid autacoids: Occurrence, metabolism and bioactions

1995 • 180 citations

Phospholipids in the nervous system

1982 • 178 citations

Phospholipase D and membrane traffic

1999 • 177 citations

The protective role of plasmalogens in iron-induced lipid peroxidation

1999 • 175 citations

Phospholipid transfer proteins revisited

1997 • 175 citations

Is the high propensity of ethanolamine plasmalogens to form non-lamellar lipid structures manifested in the properties of biomembranes?

1996 • 175 citations

Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms.

1994 • 174 citations

Egg Nutrition and Biotechnology

1999 • 168 citations

Membrane phospholipid alterations in Alzheimer's disease: deficiency of ethanolamine plasmalogens.

1997 • 162 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

The prenylation of proteins

1992 • 160 citations

Phosphatidic Acid as the Biosynthetic Precursor of the Endocannabinoid 2‐Arachidonoylglycerol in Intact Mouse Neuroblastoma Cells Stimulated with Ionomycin

1999 • 159 citations

Neural membrane phospholipids in alzheimer disease

1995 • 156 citations

Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging

1995 • 155 citations

Distribution of CTP:Phosphocholine Cytidylyltransferase (CCT) Isoforms

1999 • 151 citations

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

1999 • 145 citations

Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium

1989 • 142 citations

N-acylation of ethanolamine phospholipids in canine myocardium

1982 • 138 citations

Elevated PLA2 activity in schizophrenics and other psychiatric patients

1993 • 138 citations

Cloning and Characterization of Phospholipase D from Rat Brain

1997 • 137 citations

Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain

1979 • 137 citations

Identification and Purification of Calcium‐Independent Phospholipase A₂ from Bovine Brain Cytosol

1992 • 136 citations

A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions

1998 • 136 citations

Liposome fusion catalytically induced by phospholipase C

1989 • 133 citations

New perspectives on the function of myelin galactolipids

1998 • 132 citations

Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate

1998 • 128 citations

Regional Distribution, Ontogeny, Purification, and Characterization of the Ca²⁺‐Independent Phospholipase A₂ from Rat Brain

1999 • 127 citations

Phosphatidylserine decarboxylase

1997 • 126 citations

Translocation of phospholipase A2 from cytosol to membranes in rat brain induced by calcium ions

1990 • 124 citations

Cloning and Characterization of a Second Human CTP:Phosphocholine Cytidylyltransferase

1998 • 124 citations

Plasmalogen Phospholipids as Potential Protectors Against Lipid Peroxidation of Low-Density Lipoproteins

1994 • 123 citations

S-adenosylmethionine levels in psychiatric and neurological disorders: a review

1994 • 119 citations

Differential alteration of phospholipase A2 activities in brain of patients with schizophrenia

1999 • 119 citations

Coupling Among Energy Failure, Loss of Ion Homeostasis, and Phospholipase A₂ and C Activation During Ischemia

1993 • 119 citations

Phospholipid‐Metabolizing Enzymes in Alzheimer's Disease: Increased Lysophospholipid Acyltransferase Activity and Decreased Phospholipase A₂ Activity

1998 • 118 citations

Novel inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders

1992 • 117 citations

Modulation of cell signalling by ceramides

1998 • 115 citations

Biosynthesis and possible biological functions of plasmalogens

1998 • 114 citations

Cloning, Expression, and Localization of 230-kDa Phosphatidylinositol 4-Kinase

1996 • 114 citations

Phosphatidylserine plasma membrane asymmetry in vivo: a pancellular phenomenon which alters during apoptosis

1997 • 113 citations

Decreased phospholipase A2 activity in Alzheimer brains

1995 • 109 citations

Omega-3 fatty acids and bipolar disorder: a review

1999 • 107 citations

Role of Phospholipase D Activation in Nervous System Physiology and Pathophysiology

1995 • 107 citations

Inositol monophosphatase — a putative target for Li+ in the treatment of bipolar disorder

1995 • 105 citations

Regional Levels of Free Fatty Acids and Evans Blue Extravasation After Experimental Brain Injury

1994 • 105 citations

Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation

1992 • 102 citations

Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar patients and normal subjects

1996 • 102 citations

Excitotoxicity and Neurological Disorders: Involvement of Membrane Phospholipids

1994 • 100 citations

Phosphoinositides as spatial regulators of membrane traffic

1997 • 100 citations

Neurobiology of Essential Fatty Acids

1992 • 97 citations

Phosphatidylserine synthase I and II of mammalian cells

1997 • 94 citations

Plasmalogens, phospholipases A and signal transduction

1995 • 94 citations

Glycosyl-phosphatidylinositol anchored membrane enzymes

1997 • 93 citations

Role of Ceramide in Stimulation of the Transcription of Cytosolic Phospholipase A2and Cyclooxygenase 2

1996 • 90 citations

Involvement of phospholipase A2 in neurodegeneration

1997 • 87 citations

Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth

1997 • 86 citations

Deacylation‐Reacylation of Arachidonoyl Groups in Cerebral Phospholipidsa

1989 • 86 citations

Pathways for phosphoinositide synthesis

1999 • 85 citations

Formation of N-Acyl-phosphatidylethanolamines and N-Acylethanolamines

1998 • 84 citations

Lipid modulation of nicotinic acetylcholine receptor function: the role of neutral and negatively charged lipids

1992 • 83 citations

Chronic lithium treatment decreases brain phospholipase A2 activity.

1998 • 83 citations

Choline/ethanolamine kinase from mammalian tissues

1997 • 83 citations

Quantification, characterization and fatty acid composition of lysophosphatidic acid in different rat tissues

1989 • 83 citations

CDP-choline:1,2-diacylglycerol cholinephosphotransferase

1997 • 82 citations

Inositol and Phosphoinositides — Metabolism and Regulation

1986 • 82 citations

Membrane Instability, Plasmalogen Content, and Alzheimer's Disease

1998 • 80 citations

Externalization of Phosphatidylserine May Not Be an Early Signal of Apoptosis in Neuronal Cells, but Only the Phosphatidylserine‐Displaying Apoptotic Cells Are Phagocytosed by Microglia

1998 • 80 citations

PLATELET-ACTIVATING FACTOR IN THE CNS

1996 • 80 citations

Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated‘qc fatty acids

1997 • 79 citations

Phosphoinositide signaling in human brain

1996 • 78 citations

Phosphatidylinositol synthase from mammalian tissues

1997 • 76 citations

Effects of chronic lithium treatment on protein kinase c and cyclic AMP-dependent protein phosphorylation

1991 • 75 citations

Essential Fatty Acids and Eicosanoids: Invited Papers from the Third International Congress

1993 • 74 citations

Cloning and Identification of Amino Acid Residues of Human Phospholipase Cδ1 Essential for Catalysis

1995 • 74 citations

Glycerolipid biosynthesis in eukaryotes

1996 • 74 citations

Involvement of glutamate receptors, lipases, and phospholipases in long‐term potentiation and neurodegeneration

1994 • 73 citations

Toxic Effect of Hemoglobin on Spinal Cord Neurons in Culture

1998 • 73 citations

Phospholipid trafficking and membrane biogenesis

1994 • 72 citations

Conversion of phosphatidylethanolamine to phosphatidylcholine in rat brain by the methylation pathway

1979 • 70 citations

Detection of Three Distinct Phospholipases A2 in Cultured Mast Cells1

1992 • 68 citations

Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia

1995 • 67 citations

Phospholipid biosynthetic enzymes in human brain

1997 • 65 citations

Role of lipid structure in the activation of phospholipase A₂ by peroxidized phospholipids

1993 • 65 citations

Regulation fo protein kinase C activity by various lipids

1988 • 65 citations

Phospholipase D: Role in signal transduction and membrane traffic

1996 • 65 citations

Brain Phospholipases And Their Role In Signal Transduction

1992 • 63 citations

Behavioral and neurochemical aspects of prostaglandins in brain function

1985 • 62 citations

Purification and properties of phospholipase A1 from bovine brain.

1994 • 62 citations

Molecular Insights into Alzheimer's Disease

1989 • 62 citations

Purification of a phosphatidic-acid-hydrolysing phospholipase A2 from rat brain

1995 • 62 citations

Reduced phospholipase D activity in brain tissue samples from Alzheimer's disease patients

1986 • 61 citations

THE SYNTHESIS OF CHOLINE AND ETHANOLAMINE PHOSPHOGLYCERIDES IN NEURONAL AND GLIAL CELLS OF RABBIT IN VITRO¹

1973 • 58 citations

Role of Membrane Defects in the Regulation of the Activity of Protein Kinase C

1993 • 57 citations

Phospholipid metabolism and membrane dynamics

1996 • 57 citations

Prostaglandins as Putative Neurotoxins in Alzheimer's Disease

1998 • 56 citations

Altered mitochondrial membrane fluidity in AD brain

1996 • 55 citations

Isolation, Characterization, and Regulation of Diacylglycerol Lipases from the Bovine Braina

1989 • 55 citations

Plasmalogen oxidation in human serum lipoproteins

1995 • 53 citations

Phospholipase A2 and the hypofrontality hypothesis of schizophrenia

1996 • 52 citations

Elevated cPLA₂ levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis

1996 • 51 citations

Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets

1994 • 51 citations

CDP-diacylglycerol synthase from mammalian tissues

1997 • 51 citations

Phospholipid trafficking and membrane biogenesis

1994 • 50 citations

Handbook of Essential Fatty Acid Biology

1997 • 49 citations

Accumulation of N-acyl-ethanolamine phospholipids in rat brains during post-decapitative ischemia: a 31P NMR study

1999 • 46 citations

Increased turnover of platelet phosphatidylinositol in schizophrenia

1992 • 46 citations

Lysophosphatidic Acid Decreases Glutamate and Glucose Uptake by Astrocytes

1996 • 45 citations

Downstream of Phosphatidylinositol-3 Kinase, a Multifunctional Signaling Molecule, and Its Regulation in Cell Responses

1998 • 44 citations

Effect of glutamate and its analogs on diacylglycerol and monoacylglycerol lipase activities of neuron-enriched cultures

1993 • 44 citations

Characterization of a Novel Phospholipase A₂ Activity in Human Brain

1995 • 42 citations

Regional cerebral palmitate incorporation following transient bilateral carotid occlusion in awake gerbils.

1987 • 42 citations

Characterization of Phospholipase A₂ Activity Enriched in the Nerve Growth Cone

1996 • 42 citations

Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease

1997 • 40 citations

Platelet membrane phospholipids in euthymic bipolar disorder patients: are they affected by lithium treatment?

1999 • 39 citations

Apoptosis is associated with an increase in saturated fatty acid containing phospholipids in the neuronal cell line, HN2–5

1996 • 39 citations

CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase

1997 • 38 citations

Properties of canine myocardial phosphatidylethanolamine N-acyltransferase

1984 • 38 citations

Platelet-activating factor produces neuronal growth cone collapse

1995 • 38 citations

Second messenger imbalance hypothesis of schizophrenia

1992 • 37 citations

Inositol and Phosphoinositides: Metabolism and Regulation

1985 • 37 citations

Purification of a Lysophospholipase from Bovine Brain That Selectively Deacylates Arachidonoyl-substituted Lysophosphatidylcholine

1996 • 37 citations

Choline plasmalogens, glycerophospholipid methylation, and receptor-mediated activation of adenylate cyclase.

1986 • 35 citations

The Degradation of Phospholipids, Formation of Metabolites of Arachidonic Acid, and Demyelination Following Experimental Spinal Cord Injury

1985 • 35 citations

Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice

1999 • 35 citations

Purification and characterization of PLC-βm, a muscarinic cholinergic regulated phospholipase C from rabbit brain membrane

1990 • 34 citations

Arachidonic Acid, Neurotrauma, and Neurodegenerative Diseases

1997 • 33 citations

Synthesis of choline phospholipids in neuronal and glial cell cultures by the methylation pathway

1982 • 33 citations

Identification of a 200 kDa polypeptide as type 3 phosphatidylinositol 4-kinase from bovine brain by partial protein and cDNA sequencing

1996 • 33 citations

Effect of phosphatidylserine on the binding properties of glutamate receptors in brain sections from adult and neonatal rats

1996 • 32 citations

Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells

1998 • 32 citations

Mechanisms by which thionin induces susceptibility of S49 cell membranes to extracellular phospholipase A2

1997 • 31 citations

In vivo Cerebral Incorporation of Radiolabeled Fatty Acids after Acute Unilateral Orbital Enucleation in Adult Hooded Long-Evans Rats

1994 • 31 citations

Stimulation by Ceramide of Phospholipase A2 Activation through a Mechanism Related to the Phospholipase C-Initiated Signaling Pathway in Rabbit Platelets

1999 • 29 citations

PHOSPHOCHOLINE DIGLYCERIDE TRANSFERASE ACTIVITY DURING DEVELOPMENT OF THE CHICKEN BRAIN

1972 • 29 citations

Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation

1999 • 28 citations

Plasmalogen phospholipids — facts and theses to their antioxidative qualities

1997 • 28 citations

Platelet activating factor (PAF) in memory formation: role as a retrograde messenger in long-term potentiation

1996 • 27 citations

Plasmalogen-selective phospholipase A2 and its involvement in Alzheimer's disease

1998 • 27 citations

Elevated Activities of Lipases and Lysophospholipase in Alzheimer's Disease

1990 • 27 citations

Review : Apoptosis and Spinal Cord Injury

1998 • 26 citations

Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells

1997 • 25 citations

Induction of Apoptosis by Phosphatidylserine

1998 • 25 citations

Molecular characterization of the type 2 phosphatidic acid phosphatase

1999 • 24 citations

Effect of endothelin-1 induced ischemia on peroxidative damage and membrane properties in rat striatum synaptosomes

1995 • 23 citations

Phospholipid Metabolism in Neural Membranes

1983 • 22 citations

Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line

2000 • 19 citations

Inositide Evolution: What can it tell us about Functions?

1995 • 18 citations

Platelet-activating factor: A case for its role in CNS function and brain injury

1996 • 16 citations

Rapid Changes in Phospholipid Metabolism during Secretion and Receptor Activation

1982 • 14 citations

Characterization of phospholipid methylation in rat brain myelin

1995 • 14 citations

Apoptosis and Alzheimer’s Disease

1997 • 14 citations

Brain Lipids and Disorders in Biological Psychiatry

2002 • 13 citations

Multiple roles of platelet-activating factor in the nervous system

1995 • 12 citations

Phospholipids and Signal Transmission

1993 • 11 citations

Docosahexaenoic acid-enriched foods: production of eggs and health benefits.

1999 • 5 citations

Lipid Synthesis and Targeting to the Mammalian Cell Surface

1993 • 2 citations