Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

Phosphoinositide kinases

1990 • 331 citations

Alkaline O→N-transacylation. A new method for the quantitative deacylation of phospholipids

1981 • 320 citations

Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase

1992 • 240 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

1992 • 186 citations

Phosphoinositide 3-kinase: A new effector in signal transduction?

1991 • 166 citations

Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.

1992 • 142 citations

Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.

1983 • 129 citations

“Thrombin” receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides.

1991 • 119 citations

Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation

1988 • 118 citations

A high-performance liquid chromatographic method to measure 32P incorporation into phosphorylated metabolites in cultured cells

1982 • 113 citations

Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: <scp>d</scp>-phosphatidyl-myo-inositol 3-phosphate

1989 • 104 citations

Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate

1987 • 90 citations

The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate.

1987 • 82 citations

The structure of triphosphoinositide from beef brain

1966 • 75 citations

Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations

1989 • 69 citations

Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets.

1990 • 66 citations

On the Metabolism of the Brain Phosphoinositide Complex

1962 • 60 citations

Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes

1984 • 58 citations

Turnover of phosphomonoester groups and compartmentation of polyphosphoinositides in human erythrocytes

1986 • 56 citations

Accumulation of PtdIns(3,4)P2 and PtdIns(3,4,5)P3 in thrombin-stimulated platelets. Different sensitivities to Ca2+ or functional integrin

1992 • 55 citations

A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase.

1990 • 50 citations

Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts

1991 • 27 citations

Stimulation of phosphate uptake in human platelets by thrombin and collagen. Changes in specific 32P labeling of metabolic ATP and polyphosphoinositides.

1987 • 22 citations

Ca2(+)-stimulatable and protein kinase C-inhibitable accumulation of inositol 1,3,4,6-tetrakisphosphate in human platelets

1990 • 20 citations