Inositol monophosphatase — a putative target for Li+ in the treatment of bipolar disorder

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Hudson et al.

1977 • 2,560 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 1,676 citations

LITHIUM SALTS IN THE TREATMENT OF PSYCHOTIC EXCITEMENT

1949 • 1,401 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania

1994 • 872 citations

Manic-Depressive Illness

1991 • 573 citations

THE TREATMENT OF MANIC PSYCHOSES BY THE ADMINISTRATION OF LITHIUM SALTS

1954 • 539 citations

Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex

1988 • 474 citations

Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats

1983 • 364 citations

Increased brain myo-inositol 1-phosphate in lithium-treated rats

1976 • 252 citations

Requirement of Thymus-dependent Lymphocytes for Potentiation by Adjuvants of Antibody Formation

1971 • 245 citations

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

1991 • 223 citations

Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group

1994 • 217 citations

Lithium and brain signal transduction systems

1994 • 200 citations

Altered platelet protein kinase C activity in bipolar affective disorder, manic episode

1993 • 197 citations

The purification and properties of myo-inositol monophosphatase from bovine brain

1988 • 174 citations

Chronic Sodium Valproate Selectively Decreases Protein Kinase C α and ε In Vitro

1994 • 173 citations

A review of the biochemical and neuropharmacological actions of lithium

1987 • 171 citations

Lithium Decreases Membrane‐Associated Protein Kinase C in Hippocampus: Selectivity for the α Isozyme

1993 • 161 citations

CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia

1993 • 147 citations

Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients

1992 • 139 citations

Hyperfunctional G proteins in mononuclear leukocytes of patients with mania

1991 • 132 citations

Postmortem cerebral cortex Gs α-subunit levels are elevated in bipolar affective disorder

1991 • 126 citations

Long‐term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C

1994 • 122 citations

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

1986 • 121 citations

Chronic lithium administration alters a prominent PKC substrate in rat hippocampus

1992 • 121 citations

The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation

1984 • 116 citations

Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol

1989 • 115 citations

Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder.

1978 • 108 citations

Cloning and expression of bovine brain inositol monophosphatase.

1990 • 107 citations

Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression

1993 • 105 citations

cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme

1992 • 101 citations

Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients

1991 • 100 citations

Structural Studies of Metal Binding by Inositol Monophosphatase: Evidence for Two-Metal Ion Catalysis

1994 • 98 citations

Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase

1993 • 97 citations

Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices

1990 • 97 citations

Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients

1991 • 96 citations

The Mechanisms of Action of Lithium

1991 • 96 citations

Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS

1991 • 95 citations

Structural Analysis of Inositol Monophosphatase Complexes with Substrates

1994 • 89 citations

Properties of inositol polyphosphate 1-phosphatase.

1988 • 89 citations

Effects of GTP on hormone-stimulated adenylate cyclase activity in cerebral cortex, striatum, and hippocampus from rats treated chronically with lithium

1989 • 87 citations

In Vitro and In Vivo Inhibition of Inositol Monophosphatase by the Bisphosphonate L‐690,330

1993 • 83 citations

The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate

1988 • 82 citations

The History of Lithium Therapy

1984 • 81 citations

Structure and mechanism of inositol monophosphatase

1995 • 79 citations

Lithium Reduqes the Accumulation or Inositol Polyphosphate Second Messengers Following Cholinergic Stimulation of Cerebral Cortex Slices

1989 • 75 citations

Lithium Selectively Inhibits Muscarinic Receptor‐Stimulated Inositol Tetrakisphosphate Accumulation in Mouse Cerebral Cortex Slices

1988 • 73 citations

Autoradiographic Imaging of Phosphoinositide Turnover in the Brain

1990 • 71 citations

Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania

1993 • 68 citations

Restoration of brainmyo-inositol levels in rats increases latency to lithium-pilocarpine seizures

1993 • 68 citations

Lithium and myo-inositol homeostasis

1993 • 68 citations

In Vivo Evidence that Lithium Inactivates G_i Modulation of Adenylate Cyclase in Brain

1992 • 67 citations

Lithium decreases Gs, Gi-1 and Gi-2 α-subunit mRNA levels in rat cortex

1991 • 65 citations

Probing the role of metal ions in the mechanism of inositol monophosphatase by site‐directed mutagenesis

1993 • 60 citations

Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig

1992 • 57 citations

Inhibition of the effect of lithium on brain inositol by atropine and scopolamine

1976 • 54 citations

Crystal Structure of Inositol Polyphosphate 1-Phosphatase at 2.3-.ANG. Resolution

1994 • 53 citations

Magnesium reversal of lithium inhibition of β-adrenergic and muscarinic receptor coupling to G proteins

1991 • 52 citations

Lithium at therapeutic concentrations inhibits human brain noradrenaline-sensitive cyclic AMP accumulation

1983 • 51 citations

Lithium

1993 • 51 citations

Desensitization of muscarinic stimulated hippocampal cell firing is related to phosphoinositide hydrolysis and inhibited by lithium.

1990 • 45 citations

Increased Sensitivity to Agonist Stimulation of the Ca<sup>2+</sup> Response in Neutrophils of Manic-Depressive Patients: Effect of Lithium Therapy

1993 • 45 citations

Inositol triphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures

1992 • 44 citations

Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain

1991 • 44 citations

Structural Similarities between Fructose-1,6-bisphosphatase and Inositol Monophosphatase

1993 • 43 citations

Chronic Administration of Lithium or Other Antidepressants Increases Levels of DARPP‐32 in Rat Frontal Cortex

1992 • 41 citations

Effects of lithium ex vivo on the GTP-mediated inhibition of calcium-stimulated adenylate cyclase activity in rat brain

1989 • 41 citations

The effects of acute and chronic lithium treatment on pilocarpine‐stimulated phosphoinositide hydrolysis in mouse brain in vivo

1990 • 41 citations

Lithium effects on noradrenergic-linked adenylate cyclase activity in intact rat brain: an in vivo microdialysis study

1991 • 40 citations

Intracerebroventricularmyo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats

1990 • 39 citations

Lithium Enhances Accumulation of [³H]Inositol Radioactivity and Mass of Second Messenger Inositol 1,4,5‐Trisphosphate in Monkey Cerebral Cortex Slices

1992 • 37 citations

Myo-inositol attenuates two specific behavioral effects of acute lithium in rats.

1991 • 36 citations

Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.

1994 • 33 citations

Lithium and the Cell

1986 • 29 citations

Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium

1990 • 28 citations

Chronic lithium treatment inhibits basal and agonist-stimulated responses in rat cerebral cortex and GH3 pituitary cells.

1992 • 28 citations

Demonstration of inhibition of cyclic AMP accumulation in brain by very low concentrations of lithium in the presence of α-adrenoceptor blockade

1992 • 17 citations

Evidence for lithium-sensitive inositol 4,5-bisphosphate accumulation in muscarinic cholinoceptor-stimulated cerebral-cortex slices

1992 • 17 citations

Comparative Effects of Lithium on the Phosphoinositide Cycle in Rat Cerebral Cortex, Hippocampus, and Striatum

1993 • 17 citations

Characterization of the effects of lithium on phosphatidylinositol (PI) cycle activity in human muscarinic ml receptor‐transfected CHO cells

1993 • 16 citations

The agonist-stimulated accumulation of inositol phosphates is attenuated in neutrophils from male patients under chronic lithium therapy

1991 • 16 citations

Lithium treatment of affective disorders: effects of lithium on the inositol phospholipid and cyclic AMP signalling pathways

1992 • 16 citations

Elevated Phosphatidyl‐CMP Is Not the Source of Diacylglycerol Accumulation Induced by Lithium in NG108‐15 Cells

1993 • 15 citations

Inhibitors of inositol monophosphatase

1994 • 14 citations

Receptor coupling to G proteins: Interactions not affected by lithium

1991 • 13 citations

Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus

1994 • 13 citations

Characterization of inositol monophosphatase in human cerebrospinal fluid

1993 • 12 citations

Muscarinic Receptor‐Mediated Increase in Extracellular Inositol 1,4,5‐Trisphosphate Levels in the Rat Hippocampus: An In Vivo Microdialysis Study

1994 • 9 citations

Decreased CSF inositol monophosphatase activity after lithium treatment

1994 • 7 citations