Phospholipid biosynthetic enzymes in human brain

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Mechanism of Arachidonic Acid Liberation During Ischemia in Gerbil Cerebral Cortex

1987 • 271 citations

Postmortem Changes of Amino Compounds in Human and Rat Brain

1981 • 240 citations

An In Vivo Study of the Prefrontal Cortex of Schizophrenic Patients at Different Stages of Illness via Phosphorus Magnetic Resonance Spectroscopy

1995 • 203 citations

Regulation of phosphatidylcholine biosynthesis

1990 • 187 citations

Increased Phospholipid Breakdown in Schizophrenia

1997 • 181 citations

Characterization of phospholipase A2 (PLA2) activity in gerbil brain: enhanced activities of cytosolic, mitochondrial, and microsomal forms after ischemia and reperfusion

1991 • 151 citations

Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study.

1988 • 129 citations

Citicoline Improves Verbal Memory in Aging

1996 • 124 citations

Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain

1993 • 114 citations

31P Nuclear Magnetic Resonance Spectroscopy: Neurodevelopment and Schizophrenia

1993 • 114 citations

Effect of Choline Deficiency on the Enzymes that Synthesize Phosphatidylcholine and Phosphatidylethanolamine in Rat Liver

1978 • 110 citations

Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver.

1975 • 102 citations

Evidence that 5′‐Cytidinediphosphocholine Can Affect Brain Phospholipid Composition by Increasing Choline and Cytidine Plasma Levels

1995 • 101 citations

Choline Administration Elevates Brain Phosphorylcholine Concentrations

1982 • 89 citations

Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates

1989 • 80 citations

Effects of CDP-choline on the recovery of patients with head injury

1991 • 70 citations

Effects of Altered Phosphorylation Sites on the Properties of CTP:Phosphocholine Cytidylyltransferase

1995 • 70 citations

Effect of Cytidine on Membrane Phospholipid Synthesis in Rat Striatal Slices

1995 • 66 citations

The Association of Lipid Activators with the Amphipathic Helical Domain of CTP:Phosphocholine Cytidylyltransferase Accelerates Catalysis by Increasing the Affinity of the Enzyme for CTP

1995 • 65 citations

Metabolism of cytidine (5′)-diphosphocholine (cdp-choline) following oral and intravenous administration to the human and the rat

1987 • 62 citations

Expression of Wild-Type and Mutant Rat Liver CTP: Phosphocholine Cytidylyltransferase in a Cytidylyltransferase-Deficient Chinese Hamster Ovary Cell Line

1994 • 57 citations

Enhancement by Cytidine of Membrane Phospholipid Synthesis

1992 • 56 citations

Phosphatidylethanolamine metabolism in rat liver after partial hepatectomy. Control of biosynthesis of phosphatidylethanolamine by the availability of ethanolamine

1992 • 54 citations

Phospholipid Abnormalities in Early Alzheimer's Disease

1995 • 48 citations

Characterization of Lysophospholipid Metabolizing Enzymes in Human Brain

1994 • 48 citations

Immunological characterization, lipid dependence, and subcellular localization of CTP:phosphoethanolamine cytidylyltransferase purified from rat liver. Comparison with CTP:phosphocholine cytidylyltransferase.

1993 • 41 citations

Cerebral ischemia: Changes in brain choline, acetylcholine, and other monoamines as related to energy metabolism

1991 • 40 citations

Oral Cytidine 5′‐Diphosphate Choline Administration to Rats Increases Brain Phospholipid Levels

1993 • 33 citations

[30] Ethanolamine-phosphate cytidylyltransferase

1992 • 33 citations

Effects of orally administered cytidine 5′-diphosphate choline on brain phospholipid content

1992 • 28 citations

31P Nuclear Magnetic Resonance Spectroscopy

1996 • 26 citations

Microsomal CTP: choline phosphate cytidylyltransferase: kinetic mechanism of fatty acid stimulation

1991 • 21 citations

Kinetic and biochemical properties of CTP:choline‐phosphate cytidylyltransferase from the rat brain

1988 • 21 citations

Choline regulates phosphatidylethanolamine biosynthesis in isolated hamster heart.

1982 • 20 citations

Regulation of phosphatidylcholine biosynthesis

1991 • 18 citations

Phospholipid metabolite levels are altered in cerebral cortex of patients with dominantly inherited olivopontocerebellar atrophy

1993 • 15 citations

Multiple forms of the enzyme glycerophosphodiesterase are present in human brain

1995 • 15 citations

Effects of ethanolamine (ETN) Administration on etn and choline (CH) levels in plasma, brain extracellular fluid (ECF) and brain tissue, and on brain phospholipid levels in rats: An in vivo study

1996 • 12 citations

Changes in lipid metabolites and enzymes in rat brain due to ischemia and recirculation

1991 • 12 citations

Glycerophosphoethanolamine concentration is elevated in brain of patients with dominantly inherited olivopontocerebellar atrophy

1990 • 8 citations

Choline Deficiency in Cultured Adrenal Medullary Cells: Effect on Phosphatidylcholine Biosynthesis

1994 • 1 citations

Changes in Metabolism of Ethanolamine and Its Derivatives in Liver During Fasting

1975 • 1 citations