Phospholipase D: Role in signal transduction and membrane traffic

ADVANCES IN LIPID RESEARCH

1966 • 1,199 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Lipid second messengers

1994 • 357 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

The base exchange enzymes and phospholipase D of mammalian tissue

1980 • 226 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids.

1994 • 192 citations

Phospholipase D

1978 • 190 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Phospholipase D and cell signaling

1993 • 161 citations

Identification and Characterization of a Gene Encoding Phospholipase D Activity in Yeast

1996 • 150 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Regulation of Phospholipase D in HL60 Cells

1995 • 145 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Purification and characterization of phosphatidylcholine phospholipase D from pig lung.

1994 • 137 citations

Signal-activated phospholipases

1994 • 134 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells

1995 • 115 citations

Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains.

1993 • 107 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization.

1990 • 100 citations

Biochemical characterization of phospholipase D activity from human neutrophils

1989 • 55 citations

Inhibition of neural phospholipase D activity by aminoglycoside antibiotics

1991 • 52 citations

ARF-regulated phospholipase D: a potential role in membrane traffic

1996 • 52 citations

Ca2+ inhibits guanine nucleotide-activated phospholipase D in neural-derived NG108-15 cells.

1991 • 43 citations

Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH‐3T3 fibroblasts

1993 • 42 citations

Substrate specificity of neutral phospholipase D from rat brain studied by selective labeling of endogenous synaptic membrane phospholipids in vitro.

1992 • 35 citations

Lipid Metabolism in Signaling Systems

1993 • 18 citations

Rat Brain Membrane-Bound Phospholipase D

1993 • 14 citations

Requirement of adenosine 5′-triphosphate and Ca2+ for guanosine 5′-triphosphate-binding protein-mediated phospholipase D activation in rat pheochromocytoma PC12 cells

1993 • 10 citations