Arachidonic Acid, Neurotrauma, and Neurodegenerative Diseases

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

1994 • 3,002 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Mechanisms of free radical oxidation of unsaturated lipids

1995 • 1,158 citations

Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain

1970 • 854 citations

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

1991 • 645 citations

A case of human linolenic acid deficiency involving neurological abnormalities

1982 • 529 citations

Are long-chain polyunsaturated fatty acids essential nutrients in infancy?

1995 • 524 citations

Arachidonic acid status correlates with first year growth in preterm infants.

1993 • 518 citations

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca²⁺ and Na⁺: Implications for Neurodegeneration

1994 • 492 citations

Vitamin E and oxidative stress

1991 • 461 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

1991 • 449 citations

Oxidative damage in neurodegenerative disease

1994 • 428 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Oxygen free radicals and human disease

1995 • 378 citations

Lipid second messengers

1994 • 357 citations

Modulation of ion channel activity: a key function of the protein kinase C enzyme family.

1989 • 338 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids.

1994 • 297 citations

Arachidonic acid as a neurotoxic and neurotrophic substance

1995 • 275 citations

Fatty acid levels in the brains of schizophrenics and normal controls

1991 • 250 citations

Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction

1990 • 247 citations

Brain Edema: Induction in Cortical Slices by Polyunsaturated Fatty Acids

1978 • 242 citations

Control of arachidonate levels within inflammatory cells

1996 • 238 citations

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

1995 • 230 citations

Neurotransmitter-mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids.

1992 • 213 citations

Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling

1990 • 200 citations

Direct Measurement of Hydroxyl Radicals, Lipid Peroxidation, and Blood–Brain Barrier Disruption Following Unilateral Cortical Impact Head Injury in the Rat

1994 • 195 citations

Reductions of Γ‐Aminobutyric Acid and Glutamate Uptake and (Na⁺+ K⁺)‐ATPase Activity in Brain Slices and Synaptosomes by Arachidonic Acid

1983 • 194 citations

Arachidonate is a potent modulator of human heat shock gene transcription.

1994 • 192 citations

Importance of Pharmacologic Considerations in the Evaluation of New Treatments for Acute Spinal Cord Injury

1992 • 188 citations

Activation of Ethanolamine Phospholipase A₂ in Brain During Ischemia

1982 • 183 citations

Differential Modulation of Human Glutamate Transporter Subtypes by Arachidonic Acid

1995 • 174 citations

Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms.

1994 • 174 citations

Membrane lipid changes in laminectomized and traumatized cat spinal cord.

1985 • 166 citations

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease

1994 • 166 citations

Increased platelet phospholipase A2 activity in schizophrenia

1995 • 163 citations

Neural membrane phospholipids in alzheimer disease

1995 • 156 citations

Effects of Arachidonic Acid on Glutamate and γ‐Aminobutyric Acid Uptake in Primary Cultures of Rat Cerebral Cortical Astrocytes and Neurons

1986 • 153 citations

Characterization of phospholipase A2 (PLA2) activity in gerbil brain: enhanced activities of cytosolic, mitochondrial, and microsomal forms after ischemia and reperfusion

1991 • 151 citations

Cerebral Phosphoinositide, Triacylglycerol, and Energy Metabolism in Reversible Ischemia: Origin and Fate of Free Fatty Acids

1986 • 150 citations

Advanced Maillard Reaction End Products, Free Radicals, and Protein Oxidation in Alzheimer's Disease^a

1994 • 146 citations

Increased phospholipase C activity after experimental brain injury

1982 • 143 citations

Regulation of gene transcription by polyunsaturated fatty acids

1993 • 139 citations

LIPID COMPOSITION OF MYELIN FROM THE PERIPHERAL NERVOUS SYSTEM

1967 • 138 citations

Identification and Purification of Calcium‐Independent Phospholipase A₂ from Bovine Brain Cytosol

1992 • 136 citations

Arachidonic Acid Increases Inositol Phospholipid Metabolism and Glutamate Release in Synaptosomes Prepared from Hippocampal Tissue

1990 • 132 citations

Arachidonic acid binds to apolipoprotein D: implications for the protein's function

1995 • 132 citations

Brain Phospholipase A₂ Is Activated After Experimental Closed Head Injury in the Rat

1989 • 130 citations

Protection by prostaglandins from glutamate toxicity in cortical neurons☆

1994 • 127 citations

Dehydrozingerone and isoeugenol as inhibitors of lipid peroxidation and as free radical scavengers

1993 • 127 citations

Arachidonic Acid Inhibits a Purified and Reconstituted Glutamate Transporter Directly from the Water Phase and Not via the Phospholipid Membrane

1995 • 123 citations

The Influence of Bicuculline‐Induced Seizures on Free Fatty Acid Concentrations in Cerebral Cortex, Hippocampus, and Cerebellum

1982 • 121 citations

Milk Composition in Women from Five Different Regions of China: The Great Diversity of Milk Fatty Acids

1995 • 120 citations

Membrane lipids in the pathogenesis of brain edema: phospholipids and arachidonic acid, the earliest membrane components changed at the onset of ischemia.

1980 • 118 citations

Arachidonic Acid in the Modulation of Excitable Membrane Function and at the Onset of Brain Damagea

1989 • 108 citations

Neurochemical aspects of Alzheimer's disease: Involvement of membrane phospholipids

1988 • 108 citations

Epileptic brain damage: pathophysiology and neurochemical pathology.

1986 • 103 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

Swelling, Acidosis, and Irreversible Damage of Glial Cells from Exposure to Arachidonic Acid in vitro

1994 • 98 citations

Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.

1987 • 98 citations

Arachidonic acid as a possible negative feedback inhibitor of nicotinic acetylcholine receptors on neurons

1995 • 97 citations

Arachidonic acid activation of a new family of K+ channels in cultured rat neuronal cells.

1995 • 95 citations

The Relation of Oxidative Stress and Hyperexcitation to Neurological Disease

1995 • 90 citations

Arachidonic acid: Toxic and trophic effects on cultured hippocampal neurons

1994 • 86 citations

Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naive patients at the onset of psychosis

1994 • 83 citations

Essential fatty acids in plasma phospholipids in schizophrenics

1989 • 79 citations

Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites.

1989 • 78 citations

Formula 18:2(n-6) and 18:3(n-3) Content and Ratio Influence Long-Chain Polyunsaturated Fatty Acids in the Developing Piglet Liver and Central Nervous System

1994 • 75 citations

Evidence for the Involvement of Carnitine‐Dependent Long‐Chain Acyltransferases in Neuronal Triglyceride and Phospholipid Fatty Acid Turnover

1994 • 58 citations

Protein kinase C subspecies in adult rat hippocampal synaptosomes Activation by diacylglycerol and arachidonic acid

1991 • 56 citations

Modulation of Ca2+ cycling in cardiac myocytes by arachidonic acid.

1993 • 56 citations

Isolation, Characterization, and Regulation of Diacylglycerol Lipases from the Bovine Braina

1989 • 55 citations

Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes

1992 • 55 citations

Lipid alterations following impact spinal cord injury in the rat

1994 • 52 citations

Membrane fatty acid composition shows δ-6-desaturase abnormalities in Alzheimerʼs disease

1990 • 48 citations

Arachidonic acid depresses non-NMDA receptor currents

1994 • 47 citations

Free Fatty Acids, Neutral Glycerides, and Phosphoglycerides in Transient Focal Cerebral Ischemia

1995 • 44 citations

Protein kinase C: Cellular target of the second messenger arachidonic acid?

1995 • 43 citations

Arachidonic acid regulates unsaturated fatty acid synthesis in lymphocytes by inhibiting stearoyl-CoA desaturase gene expression

1992 • 41 citations

Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

1995 • 41 citations

Eicosanoids, plasma membranes, and molecular mechanisms of spinal cord injury

1987 • 31 citations

Essential Fatty Acids in Alzheimer's Diseasea

1991 • 30 citations

Breakdown of membrane phospholipids in Alzheimer disease

1995 • 29 citations

Regulation of transmembrane ion transport by reaction products of phospholipase A2. I. Effects of lysophospholipids on mitochondrial Ca2+ transport

1989 • 27 citations

Inhibition by fatty acids of cyclic AMP‐dependent protein kinase activity in brush border membranes isolated from human placental vesicles

1994 • 23 citations

Diacylglycerol Kinase Is Stimulated by Arachidonic Acid in Neural Membranes

1994 • 19 citations

Suppression of platelet-derived growth factor receptor tyrosine kinase activity by unsaturated fatty acids.

1993 • 18 citations

Synergistic potentiation of glutamate release by arachidonic acid and oleoyl-acetyl-glycerol

1993 • 16 citations

Prostaglandin E1 suppression of platelet aggregation response in schizophrenia

1991 • 14 citations

Alterations of cerebromicrovascular Na+, K+-ATPase activity due to fatty acids and acute hypertension

1993 • 10 citations

Ischemia Stress and Arachidonic Acid Metabolites in the Fetal Braina

1989 • 9 citations

Modulation by protein kinase C of arachidonic acid release from permeabilised myometrial cells of guinea pig uterus.

1993 • 2 citations