Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline

NCT04484454

NAINTERVENTIONAL

Neurological Associates of West Los Angeles

20 participants

Started 2020-07-17 · Completed 2021-03-13

Status: Completed (as of 12-23-2025)

Conditions

Cognitive Decline

Interventions

DIETARY_SUPPLEMENT: ProdromeNeuro Omega 3 Oil Nutritional Supplement

Linked Papers (from SciSciNet-V2)

Total Papers18

Background

5

Result

0

Derived

0

Unknown

13

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

Aging-related cognitive decline may be affected by brain cholesterol and the health of cell membranes. Certain nutritional supplements have been proposed to support membrane health, and there is increasing interest in plasmalogens and Omega-3 derived oil supplements to support brain health among older adults. The product being investigated in this study is the ProdromeNeuro Omega 3 oil nutritional supplement. This product contains naturally occurring fatty acids in higher concentrations than similar products that are commercially available. The purpose of this research study is to better understand the effects of ProdromeNeuro Omega-3 nutritional supplementation among subjects with age-related cognitive decline.

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Background Papers10

Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether

Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether

Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

Plasmalogens and Alzheimer’s disease: a review

Plasmalogens and Alzheimer’s disease: a review

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers13

Functions of plasmalogen lipids in health and disease

Cholesterol metabolism in the brain

Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders

Old and new generation lipid mediators in acute inflammation and resolution

Epidemiology of Parkinson Disease

Apolipoprotein E Exhibits Isoform‐Specific Promotion of Lipid Efflux from Astrocytes and Neurons in Culture

The protective role of plasmalogens in iron-induced lipid peroxidation

Curvilinear regression course of human brain lipid composition changes with age

Parameters related to lipid metabolism as markers of myelination in mouse brain

Changes of membrane phospholipid composition of human erythrocytes in hyperlipidemias. I. Increased phosphatidylcholine and reduced sphingomyelin in patients with elevated levels of triacylglycerol-rich lipoproteins

Plasmalogen Phospholipids Are Involved in HDL-Mediated Cholesterol Efflux: Insights from Investigations with Plasmalogen-Deficient Cells

Links between ApoE, brain cholesterol metabolism, tau and amyloid β-peptide in patients with cognitive impairment

Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia