The origins of cancer robustness and evolvability

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MicroRNA expression profiles classify human cancers

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Crystal structure of the nucleosome core particle at 2.8 Å resolution

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Genetic Alterations during Colorectal-Tumor Development

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The Clonal Evolution of Tumor Cell Populations

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A microRNA expression signature of human solid tumors defines cancer gene targets

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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Metabolic stability and epigenesis in randomly constructed genetic nets

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Why do cancers have high aerobic glycolysis?

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The Epigenomics of Cancer

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Genetic instabilities in human cancers

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

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EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

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A microRNA polycistron as a potential human oncogene

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The Consensus Coding Sequences of Human Breast and Colorectal Cancers

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Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

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Patterns of somatic mutation in human cancer genomes

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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Bacterial Persistence as a Phenotypic Switch

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The Genomic Landscapes of Human Breast and Colorectal Cancers

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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

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Epigenetics in cancer

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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Hsp90 as a capacitor for morphological evolution

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Hypoxia in cancer: significance and impact on clinical outcome

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Adaptation from standing genetic variation

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The epigenetic progenitor origin of human cancer

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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Efficient tumour formation by single human melanoma cells

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Cancer as an evolutionary and ecological process

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An operational definition of epigenetics: Figure 1.

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Tumor heterogeneity: Causes and consequences

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The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

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Degeneracy and complexity in biological systems

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Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

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The age distribution of cancer and a multi-stage theory of carcinogenesis

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

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Immunity to Methylcholanthrene-Induced Sarcomas

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Protein stability promotes evolvability

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A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

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Two genetic hits (more or less) to cancer

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Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

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Evolvability

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Robustness of Cellular Functions

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Phenotypic plasticity and evolution by genetic assimilation

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Developmental plasticity and the origin of species differences

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Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice

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Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

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Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells

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Complexity and robustness

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Adaptive Therapy

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Phase II Trial of Gefitinib in Recurrent Glioblastoma

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MicroRNA-Mediated Feedback and Feedforward Loops Are Recurrent Network Motifs in Mammals

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Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer

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Homeostasis and Differentiation in Random Genetic Control Networks

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Repopulation of cancer cells during therapy: an important cause of treatment failure

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Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

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PERSPECTIVE: EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS

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Robustness and evolvability: a paradox resolved

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Phenotypic Consequences of Promoter-Mediated Transcriptional Noise

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Co-evolution of tumor cells and their microenvironment

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Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

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Smoothness within ruggedness: the role of neutrality in adaptation.

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Mechanisms of Chromosomal Instability

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Uncovering cryptic genetic variation

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Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective

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Feedback control of intercellular signalling in development

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Errors in DNA replication as a basis of malignant changes.

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Molecular chaperones and the stress of oncogenesis

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Hereditary cancer: Two hits revisited

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Inferring tumor progression from genomic heterogeneity

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Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

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p53 Enters the MicroRNA World

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Heat-shock proteins as regulators of apoptosis

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How many mutations are required for tumorigenesis? implications from human cancer data

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Tumor Hypoxia and Malignant Progression

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Evolution of neoplastic cell lineages in Barrett oesophagus

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Cancer as a robust system: implications for anticancer therapy

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Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

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Epitope Landscape in Breast and Colorectal Cancer

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A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

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Mitotic chromosomal instability and cancer: mouse modelling of the human disease

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Breast Tumor Heterogeneity: Cancer Stem Cells or Clonal Evolution?

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Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

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Chaperonin overexpression promotes genetic variation and enzyme evolution

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Mutational robustness can facilitate adaptation

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MicroRNAs and cancer: An overview

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Microenvironmental regulation of cancer development

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Highly Optimized Tolerance: Robustness and Design in Complex Systems

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Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

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Distributed robustness versus redundancy as causes of mutational robustness

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The tumor microenvironment and metastatic disease

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Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

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Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

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Chromosomal instability determines taxane response

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Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

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Hidden Reaction Norms, Cryptic Genetic Variation, and Evolvability

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Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

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Mutational Heterogeneity in Human Cancers: Origin and Consequences

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A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

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Doxorubicin gradients in human breast cancer.

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Phenotypic heterogeneity and cellular origins of T cell malignancies

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Mechanisms of Disease: cancer stem cells—targeting the evil twin

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Degeneracy: A design principle for achieving robustness and evolvability

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Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis

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Sloppiness, robustness, and evolvability in systems biology

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Karyotypic evolution in human malignant melanoma

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Regulation of DNA repair in hypoxic cancer cells

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Epistasis correlates to genomic complexity

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Survival comparison between glioblastoma multiforme and other incurable cancers

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Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

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Receptor Tyrosine Kinase Coactivation Networks in Cancer

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Degeneracy: a link between evolvability, robustness and complexity in biological systems

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Epigenetic drivers and genetic passengers on the road to cancer

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Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma

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Treatment sequencing, asymmetry, and uncertainty: protocol strategies for combination chemotherapy.

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Cancer stem cells: Back to Darwin?

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Mutator pathways unleashed by epigenetic silencing in human cancer

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A stochastic model for the origin and treatment of tumors containing drug-resistant cells

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Primitive, Quiescent and Difficult to Kill: The Role of Non-Proliferating Stem Cells in Chronic Myeloid Leukemia

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Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy

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Evolutionary dynamics of escape from biomedical intervention

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The evolutionary origin of genetic instability in cancer development

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Robustness promotes evolvability of thermotolerance in an RNA virus

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Retreatment of Lung Adenocarcinoma Patients With Gefitinib Who Had Experienced Favorable Results From Their Initial Treatment With This Selective Epidermal Growth Factor Receptor Inhibitor: A Report of Three Cases

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Efficiency of carcinogenesis with and without a mutator mutation

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Optimization of DNA polymerase mutation rates during bacterial evolution

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A theoretical quantitative model for evolution of cancer chemotherapy resistance

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Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas

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RBP2‐H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells

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Retreatment of patients with the same chemotherapy: Implications for clinical mechanisms of drug resistance

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Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment

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MicroRNAs: Oncogenes, tumor suppressors or master regulators of cancer heterogeneity?

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Cancer models, genomic instability and somatic cellular Darwinian evolution

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Optimal control for a stochastic model of cancer chemotherapy

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Glutathione and Gts1p drive beneficial variability in the cadmium resistances of individual yeast cells

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On the karyotypic origin and evolution of cancer cells

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Current trends in mathematical modeling of tumor–microenvironment interactions: a survey of tools and applications

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Scale-free flow of life: on the biology, economics, and physics of the cell

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Cell scattering and migration induced by autocrine transforming growth factor alpha in human glioma cells in vitro.

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The age distribution of cancer and a multi-stage theory of carcinogenosis

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Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems

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Oncogenic Mutations Reduce the Stability of Src Kinase

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Epigenetics and cancer without genomic instability

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Re-Expression of the Retinoblastoma-Binding Protein 2-Homolog 1 Reveals Tumor-Suppressive Functions in Highly Metastatic Melanoma Cells

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Synonymous Genes Explore Different Evolutionary Landscapes

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Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma

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Cancer stem cells: A guide for skeptics

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Modeling therapy resistance in genetically engineered mouse cancer models

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Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer.

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Mutator Mutations Enhance Tumorigenic Efficiency across Fitness Landscapes

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Evolutionary dynamics and highly optimized tolerance

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How evolution guides complexity

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Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes

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The stability of various adaptations of Bact. lactis aerogenes (Aerobacter aerogenes)

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Familial cutaneous melanoma and two-mutational-event modeling

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