PERSPECTIVE: EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS

Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

2002 • 7,125 citations

HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology

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Network motifs in the transcriptional regulation network of Escherichia coli

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Punctuated equilibria: an alternative to phyletic gradualism

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Hsp90 as a capacitor for morphological evolution

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The strategy of the genes

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Developmental Constraints and Evolution: A Perspective from the Mountain Lake Conference on Development and Evolution

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Hsp90 as a capacitor of phenotypic variation

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The segment polarity network is a robust developmental module

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GENETIC ASSIMILATION OF AN ACQUIRED CHARACTER

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Evolvability

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THE MOLECULAR BASIS OF DOMINANCE

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Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.

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Role of duplicate genes in genetic robustness against null mutations

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The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities

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From sequences to shapes and back: a case study in RNA secondary structures

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Factors of Evolution:. The Theory of Stabilizing Selection

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Principles for the Buffering of Genetic Variation

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Principles for the Buffering of Genetic Variation

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The Mathematical Theory of Selection, Recombination, and Mutation

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Evolution of digital organisms at high mutation rates leads to survival of the flattest

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Waddington's canalization revisited: Developmental stability and evolution

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Epistasis and the Evolutionary Process

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Mapping phenotypes: canalization, plasticity and developmental stability

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Further studies on the nature and causes of gene mutations.

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A POPULATION GENETIC THEORY OF CANALIZATION

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Continuity in Evolution: On the Nature of Transitions

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Plasticity, evolvability, and modularity in RNA

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Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

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Cells, Embryos and Evolution

1997 • 450 citations

PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION

1999 • 449 citations

Epistasis and the Evolutionary Process

2000 • 434 citations

Test of synergistic interactions among deleterious mutations in bacteria

1997 • 432 citations

The Evolution of Developmental Pathways

2002 • 414 citations

Robustness against mutations in genetic networks of yeast

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Comparing Mutational Variabilities

1996 • 409 citations

The Evolution of Developmental Pathways

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Cells, embryos and evolution

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Phenotypic plasticity: linking molecular mechanisms with evolutionary outcomes

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Canalization, developmental stability, and morphological integration in primate limbs

2002 • 378 citations

One Sequence, Two Ribozymes: Implications for the Emergence of New Ribozyme Folds

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Fighting change with change: adaptive variation in an uncertain world

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Canalization in evolutionary genetics: a stabilizing theory?

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Physiological and Evolutionary Theories of Dominance

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The Possible Modification of the Response of the Wild Type to Recurrent Mutations

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DOES EVOLUTIONARY PLASTICITY EVOLVE?

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Between genotype and phenotype: protein chaperones and evolvability

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From genotype to phenotype: buffering mechanisms and the storage of genetic information

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GroEL buffers against deleterious mutations

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A single mode of canalization

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Redundancy, antiredundancy, and the robustness of genomes

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Canalization: Genetic and Developmental Aspects

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Effect of EngineeringHsp70Copy Number on Hsp70 Expression and Tolerance of Ecologically Relevant Heat Shock in Larvae and Pupae ofDrosophila Melanogaster

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Fisher's Theory of Dominance

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How should we explain variation in the genetic variance of traits?

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Robustness, Flexibility, and the Role of Lateral Inhibition in the Neurogenic Network

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Untitled

1998 • 203 citations

THE EVOLUTION OF CANALIZATION AND THE BREAKING OF VON BAER'S LAWS: MODELING THE EVOLUTION OF DEVELOPMENT WITH EPISTASIS

1998 • 188 citations

Developmental stability of insecticide resistant phenotypes in blowfly; a result of canalizing natural selection

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Marginal fitness contributions of nonessential genes in yeast

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Modelling ‘evo‐devo’ with RNA

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The differential genetic and environmental canalization of fitness components in Drosophila melanogaster

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Gene Regulatory Networks Generating the Phenomena of Additivity, Dominance and Epistasis

2000 • 159 citations

FACTORS AFFECTING THE GENETIC LOAD IN DROSOPHILA: SYNERGISTIC EPISTASIS AND CORRELATIONS AMONG FITNESS COMPONENTS

2000 • 145 citations

Evolution of mutational robustness

2003 • 142 citations

The Changes in Genetic and Environmental Variance With Inbreeding in Drosophila melanogaster

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THE EVOLUTION OF GENETIC CANALIZATION UNDER FLUCTUATING SELECTION

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A Note on Fisher's Theory of the Origin of Dominance, and on a Correlation between Dominance and Linkage

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Canalization: A molecular genetic perspective

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Mutation–Selection Balance: Ancestry, Load, and Maximum Principle

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Epistasis in Polygenic Traits and the Evolution of Genetic Architecture under Stabilizing Selection

2003 • 130 citations

Test of Interaction Between Genetic Markers That Affect Fitness in Aspergillus niger

1997 • 124 citations

A gene's eye view of epistasis, selection and speciation

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A test of Fisher's theory of dominance.

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The nature of robustness in development

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CANALIZATION OF THE SCUTE PHENOTYPE OF DROSOPHILA

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Genetic Variation and Progressive Evolution

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AN EPISTATIC GENETIC BASIS FOR FLUCTUATING ASYMMETRY OF MANDIBLE SIZE IN MICE

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Adaptive Inertia Caused by Hidden Pleiotropic Effects

1997 • 85 citations

GenomeHistory: a software tool and its application to fully sequenced genomes

2002 • 83 citations

The evolution of dominance

1999 • 77 citations

Two Further Notes on the Origin of Dominance

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Naturally occurring genetic variation affects Drosophila photoreceptor determination

1998 • 72 citations

A Metabolic Basis for Dominance and Recessivity

1996 • 70 citations

EPISTASIS BETWEEN NEW MUTATIONS AND GENETIC BACKGROUND AND A TEST OF GENETIC CANALIZATION

2001 • 67 citations

TEST OF INTERACTION BETWEEN GENETIC MARKERS THAT AFFECT FITNESS INASPERGILLUS NIGER

1997 • 65 citations

THE EVOLUTION OF DOMINANCE: A THEORY WHOSE TIME HAS PASSED?

1997 • 65 citations

Potential Variance Affecting Homeotic Ultrabithorax and Antennapedia Phenotypes in Drosophila melanogaster

1999 • 59 citations

Is Function of the Drosophila Homeotic Gene Ultrabithorax Canalized?

1997 • 55 citations

The evolutionary links between fixed and variable traits

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Dominance is not Inevitable

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Gene Conversion may aid Adaptive Peak Shifts

2000 • 31 citations

Dominance—One Hundred and Fifteen years after Mendel's paper

1996 • 28 citations

FIXATION OF CLONAL LINEAGES UNDER MULLER'S RATCHET

2000 • 27 citations

Further notes on the evolution of dominance

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Selection on Morphological Patterns

1988 • 10 citations