Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study

1998 • 739 citations

Histological Typing of Intestinal Tumours

1989 • 617 citations

Short telomeres on human chromosome 17p

1998 • 367 citations

Association of p53 mutations with short survival in colorectal cancer

1994 • 357 citations

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

1999 • 322 citations

Molecular interactions in the Vogelstein model of colorectal carcinoma

2000 • 178 citations

Short telomeres on human chromosome 17p

1998 • 159 citations

Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer

1998 • 151 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas

1994 • 132 citations

Prognostic significance of allelic loss at chromosome 18q21 for stage II colorectal cancer

1998 • 131 citations

Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality

1998 • 128 citations

ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer.

1995 • 122 citations

Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer.

1995 • 120 citations

p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer

2000 • 118 citations

Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability

1999 • 116 citations

Heterogeneity of colorectal adenocarcinomas evaluated by flow cytometry and histopathology

1985 • 112 citations

Intratumor cellular heterogeneity and alterations in ras oncogene and p53 tumor suppressor gene in human prostate carcinoma.

1995 • 105 citations

A frequent alteration of p53 gene in carcinoma in adenoma of colon.

1994 • 105 citations

The Type of K-ras Mutation Determines Prognosis in Colorectal Cancer

1998 • 92 citations

Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas

1996 • 82 citations

Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon

1996 • 81 citations

Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.

1995 • 79 citations

Current status of adjuvant chemotherapy for colorectal cancer: Can molecular markers play a role in predicting prognosis?

1992 • 78 citations

K‐ras point mutations in human colorectal carcinomas: Relation to aneuploidy and metastasis

1992 • 77 citations

Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy.

1996 • 69 citations

Genomic instability: first step to carcinogenesis.

2000 • 58 citations

Current status of adjuvant chemotherapy for colorectal cancer: Can molecular markers play a role in predicting prognosis?

1992 • 54 citations

An improved method for rapid screening of DNA mutations by nonradioactive single-strand conformation polymorphism procedure.

1993 • 52 citations

Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers.

1995 • 51 citations

DNA methylation and chromosome instability in breast cancer cell lines

1999 • 44 citations

Microdissection by Exclusion and DNA Extraction for Multiple PCR Analyses from Archival Tissue Sections

2000 • 33 citations

Genetic diversity at the p53 locus between primary human colorectal adenocarcinomas and their lymph-node metastases

1997 • 23 citations

Intratumor heterogeneity of chromosome 1, 7, 17, and 18 aneusomies obtained by FISH and association with flow cytometric DNA index in human colorectal adenocarcinomas

1999 • 21 citations

Regulation and regulatory activities of centrosomes

1999 • 20 citations

Comparison of phenotypic and genotypic features in human primary large bowel carcinomas and lymph node metastases.

1987 • 14 citations

Analysis of subclonal expansion of colorectal carcinomas by flow cytometry

1999 • 13 citations

Alteration of p53 Clonality Accompanying Colorectal Cancer Progression

1998 • 12 citations

Clonal Heterogeneity in Human Esophageal Squamous Cell Carcinomas on DNA Analysis

1996 • 12 citations

Intratumoral heterogeneity in colorectal carcinoma: trucut sampling for DNA ploidy analysis.

2000 • 10 citations

Flow cytometric analysis of the dna content in primary and metastatic lesions of colorectal cancer

1995 • 8 citations

Colorectal carcinoma. DNA ploidy pattern and prognosis with reference to tumor DNA heterogeneity.

1992 • 8 citations