Molecular chaperones and the stress of oncogenesis

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

2002 • 3,280 citations

Hsp90 as a capacitor for morphological evolution

1998 • 2,261 citations

Gene-expression profiles predict survival of patients with lung adenocarcinoma

2002 • 2,005 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Mechanisms of Caspase Activation and Inhibition during Apoptosis

2002 • 1,731 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery

2003 • 1,470 citations

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

2003 • 1,356 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

2000 • 1,028 citations

Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

2001 • 991 citations

Hsp27 negatively regulates cell death by interacting with cytochrome c

2000 • 972 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

Identification of CHIP, a Novel Tetratricopeptide Repeat-Containing Protein That Interacts with Heat Shock Proteins and Negatively Regulates Chaperone Functions

1999 • 904 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Heat-shock protein 70 antagonizes apoptosis-inducing factor

2001 • 846 citations

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

2000 • 828 citations

Negative regulation of the Apaf-1 apoptosome by Hsp70

2000 • 819 citations

Ways of dying: multiple pathways to apoptosis

2003 • 786 citations

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation

1997 • 750 citations

The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

2000 • 717 citations

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

1997 • 704 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases

1998 • 692 citations

Chaperoning signaling pathways: molecular chaperones as stress-sensing`heat shock' proteins

2002 • 655 citations

Escaping Cell Death: Survival Proteins in Cancer

1999 • 629 citations

CHIP Is a U-box-dependent E3 Ubiquitin Ligase

2001 • 574 citations

Heat shock protein 90 as a molecular target for cancer therapeutics

2003 • 572 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function

2003 • 519 citations

Hsp70 Prevents Activation of Stress Kinases

1997 • 516 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

1999 • 496 citations

Heat Shock Protein 70 Inhibits Apoptosis Downstream of Cytochrome c Release and Upstream of Caspase-3 Activation

2000 • 469 citations

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

1992 • 464 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

Hsp27 as a Negative Regulator of Cytochrome c Release

2002 • 429 citations

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

1995 • 428 citations

Stress management – heat shock protein-70 and the regulation of apoptosis

2001 • 428 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

1992 • 417 citations

Inhibition of Daxx-Mediated Apoptosis by Heat Shock Protein 27

2000 • 413 citations

The consequences of expressing hsp70 in Drosophila cells at normal temperatures.

1992 • 398 citations

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

2000 • 393 citations

Molecular chaperone targeting and regulation by BAG family proteins

2001 • 390 citations

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.

1992 • 376 citations

Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

2003 • 366 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage

2003 • 361 citations

The Small Heat Shock Protein αB-Crystallin Negatively Regulates Cytochrome c- and Caspase-8-dependent Activation of Caspase-3 by Inhibiting Its Autoproteolytic Maturation

2001 • 358 citations

Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation

2000 • 328 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

HSP27 Multimerization Mediated by Phosphorylation-sensitive Intermolecular Interactions at the Amino Terminus

1999 • 324 citations

Regulation of the Heat-shock Protein 70 Reaction Cycle by the Mammalian DnaJ Homolog, Hsp40

1996 • 323 citations

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

2001 • 321 citations

Expression of human HSP70 during the synthetic phase of the cell cycle.

1986 • 316 citations

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3

2000 • 313 citations

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

2002 • 312 citations

Vinblastine-induced Phosphorylation of Bcl-2 and Bcl-XL Is Mediated by JNK and Occurs in Parallel with Inactivation of the Raf-1/MEK/ERK Cascade

2000 • 291 citations

Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis

1998 • 289 citations

Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth

2001 • 279 citations

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

1996 • 274 citations

Chaperones in cell cycle regulation and mitogenic signal transduction: a review

2000 • 273 citations

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1997 • 270 citations

Regulation of heat shock protein 70 gene expression by c-myc

1984 • 270 citations

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor

2003 • 265 citations

JNK Phosphorylation and Activation of BAD Couples the Stress-activated Signaling Pathway to the Cell Death Machinery

2002 • 244 citations

Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72

1999 • 239 citations

Transcription of the human hsp70 gene is induced by serum stimulation.

1985 • 235 citations

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

In Vivo Chaperone Activity of Heat Shock Protein 70 and Thermotolerance

1999 • 227 citations

Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain.

1992 • 208 citations

Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

2000 • 200 citations

Hsp70 and Hsp40 Chaperone Activities in the Cytoplasm and the Nucleus of Mammalian Cells

1997 • 181 citations

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release

1998 • 179 citations

Over‐expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells

1995 • 178 citations

Invited Review: Interplay between molecular chaperones and signaling pathways in survival of heat shock

2002 • 178 citations

Heat Shock Protein Hsp72 Is a Negative Regulator of Apoptosis Signal-Regulating Kinase 1

2002 • 175 citations

Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli

2001 • 174 citations

Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells

1995 • 172 citations

Hsp72 and Stress Kinase c-jun N-Terminal Kinase Regulate the Bid-Dependent Pathway in Tumor Necrosis Factor-Induced Apoptosis

2002 • 170 citations

Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes.

1988 • 168 citations

Hsp72-Mediated Suppression of c-Jun N-Terminal Kinase Is Implicated in Development of Tolerance to Caspase-Independent Cell Death

2000 • 161 citations

Induced thermotolerance to apoptosis in a human T lymphocyte cell line

1992 • 149 citations

Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells

1995 • 148 citations

A Novel Association between the Human Heat Shock Transcription Factor 1 (HSF1) and Prostate Adenocarcinoma

2000 • 148 citations

Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells.

1997 • 146 citations

The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene.

1986 • 122 citations

BAG-1: a multifunctional regulator of cell growth and survival

2003 • 122 citations

Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2

2001 • 121 citations

Modulation of in Vivo HSP70 Chaperone Activity by Hip and Bag-1

2001 • 120 citations

Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology.

1996 • 120 citations

Oncogenic potential of Hsp72

1999 • 117 citations

Cells Overexpressing Hsp27 Show Accelerated Recovery from Heat-Induced Nuclear-Protein Aggregation

1994 • 114 citations

T Cell Lymphoma in Transgenic Mice Expressing the HumanHsp70Gene

1996 • 106 citations

Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein.

1987 • 102 citations

Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells

2003 • 87 citations

The Function of HSP72 in Suppression of c-Jun N-terminal Kinase Activation Can Be Dissociated from Its Role in Prevention of Protein Damage

1999 • 81 citations

Chaperone Function of sHsps

2002 • 77 citations

Inactivation of Dual-Specificity Phosphatases Is Involved in the Regulation of Extracellular Signal-Regulated Kinases by Heat Shock and Hsp72

2003 • 64 citations

Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis

2003 • 58 citations

hsp72 Inhibits Focal Adhesion Kinase Degradation in ATP-depleted Renal Epithelial Cells

2003 • 49 citations

Importance of the ATP-Binding Domain and Nucleolar Localization Domain of HSP72 in the Protection of Nuclear Proteins against Heat-Induced Aggregation

1994 • 44 citations

Heat-shock protein expression in cisplatin-sensitive and -resistant human tumor cells

1996 • 40 citations

E1a Transactivation of the Human HSP70 Promoter Is Mediated through the Basal Transcriptional Complex

1989 • 38 citations

An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death

1999 • 36 citations

The JNK phosphatase M3/6 is inhibited by protein-damaging stress

2001 • 35 citations

Inhibition of JNK signaling diminishes early but not late cellular stress‐induced apoptosis

2003 • 29 citations

The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line

2001 • 27 citations

Heat shock (hsp70) and resistance proteins in non-small cell lung carcinomas

1995 • 25 citations

Stress Induces Mitochondria-mediated Apoptosis Independent of SAPK/JNK Activation in Embryonic Stem Cells

2004 • 24 citations

Binding of Polyomavirus Large T Antigen to the Human hsp70 Promoter is not Required for trans Activation

1986 • 23 citations

Authentic temperature-regulation of a heat shock gene inserted into yeast on a high copy number vector

1992 • 23 citations

Analysis of the transcriptional activity of amplified genes in tumour cells by fluorescence in situ hybridization

1997 • 16 citations

Reduced thermotolerance in aged cells results from a loss of anhsp72-mediated control of JNK signaling pathway

1998 • 3 citations