Hereditary cancer: Two hits revisited

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Ulcerative Colitis and Colorectal Cancer

1990 • 1,755 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Antioncogenes and human cancer.

1993 • 772 citations

Chromosomal Imbalance in the Aniridia-Wilms' Tumor Association: 11p Interstitial Deletion

1978 • 726 citations

Mutation and Cancer: A Model for Wilms' Tumor of the Kidney<xref ref-type="fn" rid="FN2">2</xref>

1972 • 623 citations

Second primary neoplasms in patients with retinoblastoma

1986 • 563 citations

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

1995 • 551 citations

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour

1984 • 538 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

A General Theory of Carcinogenesis

1973 • 456 citations

Specific Chromosome Defect Associated with Human Small-Cell Lung Cancer: Deletion 3p(14-23)

1982 • 450 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours

1984 • 426 citations

Development of homozygosity for chromosome 11p markers in Wilms' tumour

1984 • 411 citations

Aniridia-Wilms’ tumor association: evidence for specific deletion of 11p13

1979 • 404 citations

Gene for Hereditary Retinoblastoma Assigned to Human Chromosome 13 by Linkage to Esterase D

1983 • 369 citations

BRCA2 mutations in primary breast and ovarian cancers

1996 • 365 citations

Regional Assignment of Genes for Human Esterase D and Retinoblastoma to Chromosome Band 13q14

1980 • 348 citations

Patient with 13 Chromosome Deletion: Evidence That the Retinoblastoma Gene Is a Recessive Cancer Gene

1983 • 342 citations

Mutation and cancer: neuroblastoma and pheochromocytoma.

1972 • 341 citations

Loss of a Harvey ras allele in sporadic Wilms' tumour

1984 • 336 citations

Chromosomal Deletion and Retinoblastoma

1976 • 283 citations

Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

1983 • 234 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Mutation and Human Cancer

1973 • 210 citations

Retinoblastoma: a prototypic hereditary neoplasm.

1978 • 197 citations

Heredity and cancer in man.

1973 • 194 citations

Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 182 citations

Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms.

1995 • 176 citations

p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma

1994 • 138 citations

Model for the incidence of embryonal cancers: application to retinoblastoma.

1978 • 134 citations

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)

1992 • 120 citations

Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia.

1981 • 117 citations

Sporadic bilateral retinoblastoma and 13q‐chromosomal deletion

1976 • 95 citations

Familial Breast Cancer, Soft-Tissue Sarcomas, and Other Neoplasms

1975 • 65 citations

Computer-Assisted Analysis of Chromosomal Abnormalities: Detection of a Deletion in Aniridia/ Wilms' Tumor Syndrome

1974 • 44 citations

Retinoblastoma A Model of Hereditary Fragile Chromosomal Regions

1975 • 41 citations

Stem cell regulation, tissue ontogeny, and oncogenic events.

1992 • 38 citations