Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes

The Hallmarks of Cancer

2000 • 27,569 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Characterizing the cancer genome in lung adenocarcinoma

2007 • 1,110 citations

Rules for Making Human Tumor Cells

2002 • 928 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

1999 • 798 citations

Characterization of a newly derived human sarcoma cell line (HT-1080)

1974 • 681 citations

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

2002 • 604 citations

NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia

2003 • 541 citations

Basis for the Acquisition of Malignant Potential by Mouse Cells Cultivated in vitro

1968 • 425 citations

PP2A: the expected tumor suppressor

2004 • 417 citations

RTCGD: retroviral tagged cancer gene database

2003 • 332 citations

Identification of specific PP2A complexes involved in human cell transformation

2004 • 318 citations

A Genetically Defined Model for Human Ovarian Cancer

2004 • 275 citations

Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation

2003 • 250 citations

Involvement of PP2A in viral and cellular transformation

2005 • 236 citations

Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses

1985 • 223 citations

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

2002 • 204 citations

The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase

2007 • 190 citations

Transformation of Human and Murine Fibroblasts without Viral Oncoproteins

2005 • 173 citations

Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

2003 • 173 citations

Transformation of normal human cells in the absence of telomerase activation

2002 • 154 citations

Debate Surges Over the Origins of Genomic Defects in Cancer

2002 • 154 citations

Tumor progression: a brief historical perspective

2002 • 144 citations

A genetically tractable model of human glioma formation.

2001 • 137 citations

Critical Role for SV40 Small-t Antigen in Human Cell Transformation

2001 • 131 citations

Derivation of human tumor cells in vitro without widespread genomic instability.

2001 • 126 citations

Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens

2006 • 119 citations

A Network of Genetic Events Sufficient to Convert Normal Human Cells to a Tumorigenic State

2005 • 107 citations

Analysis of Genomic Integrity and p53-Dependent G₁Checkpoint in Telomerase-Induced Extended-Life-Span Human Fibroblasts

1999 • 105 citations

Aneuploidy and Cancer: From Correlation to Causation

2006 • 98 citations

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

2003 • 94 citations

Functional genetics and experimental models of human cancer

2004 • 63 citations

A Genetically Defined Normal Human Somatic Cell System to Study Ras Oncogenesis In Vivo and In Vitro

2006 • 53 citations

Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line

2005 • 41 citations

Tumorigenic Conversion of Primary Human Esophageal Epithelial Cells Using Oncogene Combinations in the Absence of Exogenous Ras

2006 • 40 citations

Cellular Targets of the SV40 Small-t Antigen in Human Cell Transformation

2004 • 38 citations

Oncogenic transformation of human cells: shortcomings of rodent model systems

2004 • 35 citations

Understanding transformation: progress and gaps

2004 • 32 citations

Human Diploid Fibroblasts are Refractory to Oncogene-Mediated Transformation

2004 • 27 citations

Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts

2005 • 18 citations

Cooperation of V-oncogenes in human epithelial cell transformation.

1988 • 5 citations