Treatment sequencing, asymmetry, and uncertainty: protocol strategies for combination chemotherapy.

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Rationale for the use of alternating non-cross-resistant chemotherapy.

1982 • 545 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer

1975 • 398 citations

Clinical Pharmacodynamics of High-Dose Methotrexate in Acute Lymphocytic Leukemia

1986 • 380 citations

A Critical Appraisal of the Human Tumor Stem-Cell Assay

1983 • 365 citations

Quantitative model for multiple levels of drug resistance in clinical tumors.

1983 • 191 citations

A Stem Cell Model of Human Tumor Growth: Implications for Tumor Cell Clonogenic Assays<xref ref-type="fn" rid="FN2">2</xref>

1983 • 190 citations

Tumor cell heterogeneity : origins and implications

1982 • 159 citations

Multitype Branching Processes.

1973 • 157 citations

Stem cells in differentiation and neoplasia

1982 • 86 citations

Rapid decay of tumoricidal activity and loss of responsiveness to lymphokines in inflammatory macrophages.

1979 • 82 citations

Gene Amplification and Drug Resistance

1980 • 69 citations

Measurement of self-renewal in culture of clonogenic cells from human ovarian carcinoma

1981 • 65 citations

Development of biological diversity and susceptibility to chemotherapy in murine cancer metastases.

1984 • 61 citations

Duration of the dormant state in an established cell line of human hematopoietic cells.

1977 • 28 citations

Density/volume analysis in the study of cellular heterogeneity in human ovarian carcinoma

1982 • 27 citations

A branching-process model for heterogeneous cell populations

1986 • 22 citations

Therapeutic implications of a stem cell model for human breast cancer: a hypothesis.

1983 • 17 citations