Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

2006 • 3,040 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

The Genomic Landscapes of Human Breast and Colorectal Cancers

2007 • 2,716 citations

Large-Scale Copy Number Polymorphism in the Human Genome

2004 • 2,542 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

2007 • 1,760 citations

Characterizing the cancer genome in lung adenocarcinoma

2007 • 1,110 citations

Comparative lesion sequencing provides insights into tumor evolution

2008 • 791 citations

Role of the p16 tumor suppressor gene in cancer.

1998 • 710 citations

A high-resolution survey of deletion polymorphism in the human genome

2005 • 664 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Diabetes and obesity: the twin epidemics

2006 • 641 citations

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

1982 • 630 citations

Array comparative genomic hybridization and its applications in cancer

2005 • 583 citations

High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping

2006 • 512 citations

Whole-genome genotyping with the single-base extension assay

2005 • 362 citations

Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis

2005 • 340 citations

Pathway Mapping Tools for Analysis of High Content Data

2006 • 257 citations

Topoisomerase IIα Gene Amplification Predicts Favorable Treatment Response to Tailored and Dose-Escalated Anthracycline-Based Adjuvant Chemotherapy in HER-2/neu–Amplified Breast Cancer: Scandinavian Breast Group Trial 9401

2006 • 247 citations

Genome-Wide Loss of Heterozygosity and Copy Number Analysis in Melanoma Using High-Density Single-Nucleotide Polymorphism Arrays

2007 • 228 citations

Digital karyotyping

2002 • 219 citations

Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution

2007 • 197 citations

Three Classes of Genes Mutated In Colorectal Cancers with Chromosomal Instability

2004 • 189 citations

Mapping the Cancer Genome

2007 • 188 citations

Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies.

2007 • 174 citations

Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer.

2002 • 174 citations

Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays

2007 • 154 citations

High‐resolution genomic and expression analyses of copy number alterations in breast tumors

2008 • 151 citations

PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer

2008 • 131 citations

End-sequence profiling: Sequence-based analysis of aberrant genomes

2003 • 116 citations

Genetic alterations in cancer as a result of breakage at fragile sites

2003 • 99 citations

Chromosomal Breakpoints in Primary Colon Cancer Cluster at Sites of Structural Variants in the Genome

2008 • 85 citations

Homozygous deletion scanning of the lung cancer genome at a 100‐kb resolution

2007 • 61 citations

Emerging DNA sequencing technologies for human genomic medicine

2008 • 60 citations

The Power of Riboswitches

2007 • 51 citations

Mutational analysis of gene families in human cancer

2004 • 49 citations

Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy

2007 • 37 citations

Digital karyotyping

2007 • 23 citations