Integrins in angiogenesis and lymphangiogenesis

Inflammation and cancer

2002 • 14,174 citations

Integrins

2002 • 8,127 citations

Angiogenesis in life, disease and medicine

2005 • 3,331 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Angiogenesis as a therapeutic target

2005 • 2,543 citations

Focal adhesion kinase: in command and control of cell motility

2005 • 2,405 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Molecular regulation of angiogenesis and lymphangiogenesis

2007 • 1,891 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Prox1 Function Is Required for the Development of the Murine Lymphatic System

1999 • 1,525 citations

LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

1999 • 1,519 citations

Integrin-regulated FAK–Src signaling in normal and cancer cells

2006 • 1,456 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Ligand Binding to Integrins

2000 • 1,332 citations

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

1999 • 1,228 citations

Altered macrophage differentiation and immune dysfunction in tumor development

2007 • 1,196 citations

Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries

1999 • 1,060 citations

Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer

2006 • 1,020 citations

Inside Out

2003 • 974 citations

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

2004 • 853 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

Tumor Regression by Targeted Gene Delivery to the Neovasculature

2002 • 848 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

2007 • 757 citations

β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

1999 • 731 citations

Consequences of lack of beta 1 integrin gene expression in mice.

1995 • 724 citations

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

2005 • 714 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer.

2000 • 691 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

2005 • 678 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

2007 • 648 citations

Regulation of Angiogenesis in Vivo by Ligation of Integrin α5β1 with the Central Cell-Binding Domain of Fibronectin

2000 • 622 citations

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

2002 • 604 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 597 citations

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.

1995 • 593 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Integrins: roles in cancer development and as treatment targets

2004 • 568 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 559 citations

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

2001 • 544 citations

Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

1996 • 539 citations

INTEGRIN STRUCTURE, ALLOSTERY, AND BIDIRECTIONAL SIGNALING

2005 • 528 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

2002 • 511 citations

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

1996 • 496 citations

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

2004 • 462 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.

1996 • 443 citations

Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer

2007 • 437 citations

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin

2007 • 421 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

1998 • 397 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

2000 • 380 citations

Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3.

2000 • 372 citations

Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density

2005 • 363 citations

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine

1991 • 362 citations

Tumor-associated macrophages in breast cancer.

2002 • 346 citations

Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to α _v -Integrins

2003 • 339 citations

Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

2000 • 327 citations

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

2002 • 327 citations

Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes

2005 • 324 citations

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

2002 • 313 citations

VEGF‐A promotes tissue repair‐associated lymphatic vessel formation via VEGFR‐2 and the α1β1 and α2β1 integrins

2004 • 313 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 304 citations

Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells

2004 • 303 citations

Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma

2007 • 291 citations

LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.

1997 • 291 citations

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

2005 • 288 citations

Fibronectins Are Essential for Heart and Blood Vessel Morphogenesis But Are Dispensable for Initial Specification of Precursor Cells

1997 • 286 citations

Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1

2000 • 282 citations

Integrin-ligarid interactions: a year in review

1994 • 282 citations

Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas

2001 • 278 citations

Central Roles of α ₅ β ₁ Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

2002 • 275 citations

β8 integrins are required for vascular morphogenesis in mouse embryos

2002 • 266 citations

Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma

2004 • 251 citations

Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer.

2001 • 247 citations

A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature

2006 • 222 citations

Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death

2004 • 219 citations

Integrin β4 signaling promotes tumor angiogenesis

2004 • 217 citations

Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice

2000 • 214 citations

Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A

2000 • 214 citations

Inhibition of integrin α₅β₁ function with a small peptide (ATN‐161) plus continuous 5‐FU infusion reduces colorectal liver metastases and improves survival in mice

2003 • 213 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

The EIIIA Segment of Fibronectin Is a Ligand for Integrins α9β1 and α4β1Providing a Novel Mechanism for Regulating Cell Adhesion by Alternative Splicing

2002 • 209 citations

Integrin signaling is critical for pathological angiogenesis

2006 • 201 citations

Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation

2005 • 193 citations

The Lymphangiogenic Vascular Endothelial Growth Factors VEGF-C and -D Are Ligands for the Integrin α9β1

2004 • 189 citations

β1 Integrin Is Essential for Teratoma Growth and Angiogenesis

1997 • 185 citations

The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo

2000 • 182 citations

Tumor Targeting with RGD Peptide Ligands-Design of New Molecular Conjugates for Imaging and Therapy of Cancers

2007 • 178 citations

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

1997 • 170 citations

Essential Role of ICAM-1/CD18 in Mediating EPC Recruitment, Angiogenesis, and Repair to the Infarcted Myocardium

2006 • 167 citations

Defective Associations between Blood Vessels and Brain Parenchyma Lead to Cerebral Hemorrhage in Mice Lacking αv Integrins

2002 • 163 citations

Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State

2001 • 163 citations

Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours

2006 • 162 citations

Inhibition of endothelial cell survival and angiogenesis by protein kinase A

2002 • 161 citations

Phase I Trial of a Monoclonal Antibody Specific for αvβ3 Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion

2005 • 155 citations

The Contribution of Bone Marrow–Derived Cells to the Tumor Vasculature in Neuroblastoma Is Matrix Metalloproteinase-9 Dependent

2005 • 155 citations

Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice

2004 • 151 citations

CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo

2004 • 150 citations

Inhibition of endothelial cell survival and angiogenesis by protein kinase A

2002 • 146 citations

Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma

2001 • 143 citations

Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors

2007 • 140 citations

Prox1 Induces Lymphatic Endothelial Differentiation via Integrin α9 and Other Signaling Cascades

2007 • 139 citations

Tyrosine Phosphorylation of the β4 Integrin Cytoplasmic Domain Mediates Shc Signaling to Extracellular Signal-regulated Kinase and Antagonizes Formation of Hemidesmosomes

2001 • 136 citations

Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin

2007 • 136 citations

Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors.

1994 • 132 citations

Identification of a Novel Integrin α6β1 Binding Site in the Angiogenic Inducer CCN1 (CYR61)

2003 • 130 citations

Integrin α4β1 Promotes Monocyte Trafficking and Angiogenesis in Tumors

2006 • 126 citations

The Homeobox Transcription Factor Hox D3 Promotes Integrin α5β1 Expression and Function during Angiogenesis

2004 • 125 citations

Integrin α9β1 Directly Binds to Vascular Endothelial Growth Factor (VEGF)-A and Contributes to VEGF-A-induced Angiogenesis

2007 • 125 citations

Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability

2004 • 121 citations

Integrin αvβ3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non–small-cell lung cancer models

2006 • 120 citations

Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters.

2006 • 119 citations

A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer

2006 • 116 citations

Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma

2006 • 112 citations

Interaction of α9β1 Integrin With Thrombospondin-1 Promotes Angiogenesis

2007 • 111 citations

Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice

2004 • 107 citations

Inhibition of Inflammatory Lymphangiogenesis by Integrin α5 Blockade

2007 • 105 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 104 citations

Integrins as a distinct subtype of dependence receptors

2005 • 90 citations

β1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis

2007 • 85 citations

Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies.

2001 • 85 citations

α2β1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell–specific manner

2007 • 83 citations

Phase II Evaluations of Cilengitide in Asymptomatic Patients with Androgen-Independent Prostate Cancer: Scientific Rationale and Study Design

2006 • 79 citations

Suppression and Regression of Choroidal Neovascularization by Systemic Administration of an α₅β₁Integrin Antagonist

2006 • 73 citations

Inhibitory Effects of MLDG-containing Heterodimeric Disintegrins Reveal Distinct Structural Requirements for Interaction of the Integrin α9β1 with VCAM-1, Tenascin-C, and Osteopontin

2000 • 71 citations

Myeloid cell trafficking and tumor angiogenesis

2006 • 69 citations

Integrin Regulation by Vascular Endothelial Growth Factor in Human Brain Microvascular Endothelial Cells

2006 • 68 citations

Cooperation between VEGF and β3 integrin during cardiac vascular development

2006 • 67 citations

A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human alpha v beta 3 (avb3) integrin, ± dacarbazine (DTIC) in patients with metastatic melanoma (MM)

2005 • 55 citations

Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody.

2007 • 48 citations

A review: Integrin αvβ3-targeted molecular imaging and therapy in angiogenesis

2005 • 45 citations

Angiogenesis Inhibition and Choroidal Neovascularization Suppression by Sustained Delivery of an Integrin Antagonist, EMD478761

2007 • 45 citations

Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding

2005 • 42 citations

Expression of Integrins in Cerebral Arteriovenous and Cavernous Malformations

2005 • 41 citations

The role of integrin α5β1 in the regulation of corneal neovascularization

2007 • 40 citations

Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC)

2006 • 32 citations

Effects of a monoclonal anti-αvβ3 integrin antibody on blood vessels—A pharmacodynamic study

2006 • 31 citations

Methods to Study Lymphatic Vessel Integrins

2007 • 29 citations

Thrombopoietic Cells and the Bone Marrow Vascular Niche

2007 • 18 citations

EMD121974 (NSC 707544, cilengitide) in asymptomatic metastatic androgen independent prostate cancer (AIPCa) patients (pts): A randomized trial by the Prostate Cancer Clinical Trials Consortium (NCI 6372)

2007 • 9 citations

Disease Progression Markers in Uveitis: The Importance of Autoantibodies to Retinal S Antigen to Galectine-1, and Slpi Serum Levels

2007 • 2 citations