Integrins: roles in cancer development and as treatment targets

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Role of integrins in cell invasion and migration

2002 • 1,719 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

1998 • 834 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

1999 • 731 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Regulation of Angiogenesis in Vivo by Ligation of Integrin α5β1 with the Central Cell-Binding Domain of Fibronectin

2000 • 622 citations

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

2002 • 604 citations

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

2001 • 544 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3.

2000 • 372 citations

Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression

2001 • 334 citations

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.

1996 • 333 citations

Signaling networks linking integrins and Rho family GTPases

2000 • 310 citations

Fibronectins Are Essential for Heart and Blood Vessel Morphogenesis But Are Dispensable for Initial Specification of Precursor Cells

1997 • 286 citations

Central Roles of α ₅ β ₁ Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

2002 • 275 citations

Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins αvβ3 and αvβ5 in patients with advanced solid tumours

2003 • 223 citations

Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A

2000 • 214 citations

Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice

2000 • 214 citations

Inhibition of integrin α₅β₁ function with a small peptide (ATN‐161) plus continuous 5‐FU infusion reduces colorectal liver metastases and improves survival in mice

2003 • 213 citations

Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts.

2002 • 208 citations

Induction of the Angiogenic Phenotype by Hox D3

1997 • 208 citations

Integrin expression in human melanoma cells with differing invasive and metastatic properties

1992 • 197 citations

Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos

1997 • 193 citations

A Pilot Trial of Vitaxin, A Humanized Anti-Vitronectin Receptor (antiα_vβ₃) Antibody in Patients with Metastatic Cancer

2001 • 191 citations

Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.

1992 • 170 citations

Inhibition of endothelial cell survival and angiogenesis by protein kinase A

2002 • 161 citations

Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice.

2003 • 161 citations

Inhibition of endothelial cell survival and angiogenesis by protein kinase A

2002 • 146 citations

Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells.

2002 • 126 citations

The Homeobox Transcription Factor Hox D3 Promotes Integrin α5β1 Expression and Function during Angiogenesis

2004 • 125 citations

Expression of integrin β6 enhances invasive behavior in oral squamous cell carcinoma

2002 • 124 citations

Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1

2003 • 115 citations

Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer

2003 • 107 citations

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.

1998 • 106 citations

Parathyroid hormone–related peptide is a naturally occurring, protein kinase A–dependent angiogenesis inhibitor

2002 • 101 citations

Pilot study of vitaxin?an angiogenesis inhibitor?in patients with advanced leiomyosarcomas

2001 • 97 citations

Specific β1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A

2003 • 89 citations

Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies.

2001 • 85 citations

Integrin laminin receptors and breast carcinoma progression.

2001 • 73 citations

The α_vintegrin antagonists as novel anticancer agents: an update

2002 • 64 citations

Integrins: Structure, Function, and Biological Properties

1993 • 58 citations

Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer

2003 • 54 citations

Altered expression of α6 integrin subunit in oral squamous cell carcinoma and oral potentially malignant lesions

1998 • 36 citations

Vitaxin applied molecular evolution.

2000 • 25 citations

Cilengitide Merck.

2003 • 16 citations