Regulation of Angiogenesis in Vivo by Ligation of Integrin α5β1 with the Central Cell-Binding Domain of Fibronectin

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

1997 • 686 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

1996 • 555 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule

1981 • 444 citations

Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.

1997 • 415 citations

Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.

1996 • 405 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Interleukin-8. A corneal factor that induces neovascularization.

1992 • 385 citations

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

1997 • 380 citations

Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.

1994 • 373 citations

Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.

1993 • 344 citations

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library

1994 • 308 citations

The fibronectin isoform containing the ed‐b oncofetal domain: A marker of angiogenesis

1994 • 306 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 304 citations

Fibronectin

1998 • 301 citations

Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform

1997 • 289 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.

1990 • 282 citations

Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis

1998 • 266 citations

Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.

1994 • 247 citations

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin.

1995 • 247 citations

Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis

1991 • 247 citations

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer

1997 • 244 citations

Integrins and GTPases in tumour cell growth, motility and invasion

1998 • 219 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

Down-regulation of Vascular Endothelial Growth Factor in a Human Colon Carcinoma Cell Line Transfected with an Antisense Expression Vector Specific for c-src

1998 • 204 citations

Transient functional expression of alphaVbeta 3 on vascular cells during wound repair.

1996 • 203 citations

Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos

1997 • 193 citations

Integrins, angiogenesis and vascular cell survival

1996 • 190 citations

Growth factor production by human colon carcinoma cell lines.

1989 • 186 citations

β1 Integrin Is Essential for Teratoma Growth and Angiogenesis

1997 • 185 citations

Regional Suppression of Tumor Growth byIn VivoTransfer of a cDNA Encoding a Secreted Form of the Extracellular Domain of theflt-1Vascular Endothelial Growth Factor Receptor

1998 • 182 citations

Fibrinogen Is a Ligand for Integrin α5β1 on Endothelial Cells

1997 • 172 citations

The role of vascular endothelial growth factor in blood vessel formation

1996 • 163 citations

Alignment of biologically active domains in the fibronectin molecule.

1981 • 162 citations

Molecular framework for angiogenesis: a complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines.

1996 • 157 citations

Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues

1994 • 154 citations

Del1 Induces Integrin Signaling and Angiogenesis by Ligation of αVβ3

1999 • 150 citations

Control of Cell Cycle Progression by Fibronectin Matrix Architecture

1998 • 141 citations

Angiogenesis in Embryos and Ischemic Diseases

1997 • 139 citations

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

1992 • 126 citations

Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization.

1998 • 115 citations

Serum levels of interleukins, growth factors and anglogenin in patients with endometrial cancer

1997 • 113 citations

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.

1998 • 106 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 104 citations

Use of the 10-Day-Old Chick Embryo Model for Studying Angiogenesis

2003 • 97 citations

The αvβ3 Integrin Regulates α5β1-mediated Cell Migration toward Fibronectin

1997 • 96 citations

Fibroblast growth factors as angiogenesis factors: New insights into their mechanism of action

1997 • 88 citations

Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

1997 • 84 citations

Endothelial cell integrin α5β1 expression is modulated by cytokines and during migration in vitro

1999 • 83 citations

In vivo inhibition of angiogenesis and growth of the human U-87 malignant glial tumor by treatment with an antibody against basic fibroblast growth factor

1995 • 81 citations

Vitronectin decreases microvascular endothelial cell apoptosis

1998 • 67 citations

Spatial and temporal expression of angiogenic molecules during tumor growth and progression.

1998 • 65 citations

Function and Receptor Specificity of a Minimal 20 Kilodalton Cell Adhesive Fragment of Fibronectin

1995 • 62 citations

The role of vascular cell integrins αvß3 and αvß5 in angiogenesis

1997 • 50 citations

Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer

1997 • 50 citations