The Lymphangiogenic Vascular Endothelial Growth Factors VEGF-C and -D Are Ligands for the Integrin α9β1

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The biology of VEGF and its receptors

2003 • 9,272 citations

Integrins

2002 • 8,127 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

2003 • 1,353 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

2001 • 957 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

2001 • 754 citations

Molecular mechanisms of lymphangiogenesis in health and disease

2002 • 709 citations

Prespecification and plasticity: shifting mechanisms of cell migration

2004 • 658 citations

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

2001 • 652 citations

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

2000 • 625 citations

VEGF and VEGF-C: Specific Induction of Angiogenesis and Lymphangiogenesis in the Differentiated Avian Chorioallantoic Membrane

1997 • 501 citations

A Mechanism for Modulation of Cellular Responses to VEGF Activation of the Integrins

2000 • 441 citations

VEGF-D Is the Strongest Angiogenic and Lymphangiogenic Effector Among VEGFs Delivered Into Skeletal Muscle via Adenoviruses

2003 • 431 citations

Vascular Growth Factors and Lymphangiogenesis

2002 • 412 citations

Concurrent Induction of Lymphangiogenesis, Angiogenesis, and Macrophage Recruitment by Vascular Endothelial Growth Factor-C in Melanoma

2001 • 390 citations

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

2002 • 327 citations

Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through Phosphatidylinositol 3-Kinase-dependent Pathways

2001 • 301 citations

The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin

1999 • 299 citations

Vascular Endothelial Growth Factor Receptor-2 and Neuropilin-1 Form a Receptor Complex That Is Responsible for the Differential Signaling Potency of VEGF165 and VEGF121

2001 • 298 citations

Integrin regulation of growth factor receptors

2002 • 295 citations

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain

2000 • 289 citations

Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1

2000 • 282 citations

c- fos -induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro

1999 • 271 citations

The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

1999 • 258 citations

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

1994 • 250 citations

Therapeutic lymphangiogenesis with human recombinant VEGF‐C

2002 • 249 citations

Multiple integrins mediate cell attachment to cytotactin/tenascin.

1993 • 248 citations

Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]

1993 • 221 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.

1994 • 200 citations

Integrin (α6β4) regulation of eIF-4E activity and VEGF translation

2002 • 198 citations

Specific Interaction of Angiostatin with Integrin αvβ3 in Endothelial Cells

2001 • 196 citations

Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D

2003 • 195 citations

Expression of Vascular Endothelial Growth Factor Receptors 1, 2, and 3 in Quiescent Endothelia

2002 • 157 citations

Identification of the Ligand Binding Site for the Integrin α9β1 in the Third Fibronectin Type III Repeat of Tenascin-C

1998 • 151 citations

Characterization of indolinones which preferentially inhibit VEGF‐C‐ and VEGF‐D‐induced activation of VEGFR‐3 rather than VEGFR‐2

2001 • 104 citations

Differential regulation of airway epithelial integrins by growth factors.

1996 • 97 citations

Plasmin-induced Migration Requires Signaling through Protease-activated Receptor 1 and Integrin α9β1

2004 • 79 citations

The Cytoplasmic Domain of the Integrin α9 Subunit Requires the Adaptor Protein Paxillin to Inhibit Cell Spreading but Promotes Cell Migration in a Paxillin-independent Manner

2001 • 74 citations

Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells.

2001 • 52 citations

Tiny dancers

2002 • 49 citations

Enantioselective activation of the peroxisome proliferator-activated receptor.

1993 • 32 citations