FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

In situ Hybridization

1994 • 875 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

The hardwiring of development: organization and function of genomic regulatory systems

1997 • 704 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Five years on the wings of fork head

1996 • 657 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis

1995 • 521 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

Inhibition of activin receptor signaling promotes neuralization in Xenopus

1994 • 484 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

1991 • 373 citations

The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.

1992 • 371 citations

Xsox17α and -β Mediate Endoderm Formation in Xenopus

1997 • 354 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Physical and Functional Interaction of SMADs and p300/CBP

1998 • 351 citations

Organizer-Specific Homeobox Genes in Xenopus laevis Embryos

1991 • 349 citations

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

1995 • 331 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4

1997 • 311 citations

Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning

1996 • 309 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm

1996 • 280 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

1997 • 260 citations

Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps.

1996 • 248 citations

Active repression of transcription by the engrailed homeodomain protein.

1991 • 248 citations

A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.

1992 • 236 citations

Patterning the Xenopus blastula

1997 • 234 citations

Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer

1998 • 230 citations

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

1995 • 225 citations

Mesoderm induction by activin requires FGF-mediated intracellular signals

1994 • 225 citations

Regulation of differentiation by TFG-β

1996 • 223 citations

Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation

1996 • 206 citations

The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation

1996 • 203 citations

A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation

1997 • 197 citations

TGF-β signals and a prepattern in Xenopus laevis endodermal development

1996 • 196 citations

Efficient Hormone-Inducible Protein Function in Xenopus laevis

1995 • 190 citations

The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesoderm

1987 • 187 citations

TheXenopus Brachyurypromoter is activated by FGF and low concentrations ofactivinandsuppressed by high concentrationsof activin and by paired-type homeodomain proteins

1997 • 183 citations

Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.

1993 • 177 citations

XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm

1989 • 162 citations

Smad5 Induces Ventral Fates inXenopusEmbryo

1997 • 157 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

Induction of dorsal mesoderm by soluble, mature Vg1 protein

1995 • 150 citations

Siamois is required for formation of Spemann’s organizer

1997 • 144 citations

Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

1998 • 139 citations

Autonomous Endodermal Determination in Xenopus: Regulation of Expression of the Pancreatic Gene XlHbox 8

1995 • 134 citations

Thyroid Hormone-Dependent Regulation of the Intestinal Fatty Acid-Binding Protein Gene during Amphibian Metamorphosis

1994 • 116 citations

Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos

1992 • 114 citations

A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation

1996 • 111 citations

The Role of FAST-1 and Smads in Transcriptional Regulation by Activin during Early Xenopus Embryogenesis

1999 • 111 citations

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

1995 • 110 citations

A role for Siamois in Spemann organizer formation

1997 • 108 citations

Chapter 16 Regulation of Protein Activities by Fusion to Steroid Binding Domains

1994 • 96 citations

pXeX, a vector for efficient expression of cloned sequences in Xenopus embryos

1994 • 95 citations

Localization of MAP Kinase Activity in EarlyXenopusEmbryos: Implications for Endogenous FGF Signaling

1997 • 93 citations

The Drosophila fork head domain protein crocodile is required for the establishment of head structures.

1995 • 88 citations

The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during earlyXenopusdevelopment but do not co-operate to establish thresholds

1997 • 83 citations

A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis

1998 • 81 citations

DNA Sequences Mediating the Transcriptional Response of theMix.2Homeobox Gene to Mesoderm Induction

1996 • 79 citations

Xmsx-1 modifies mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo

1997 • 73 citations

An enhancer responsible for activating transcription at the midblastula transition in Xenopus development.

1987 • 54 citations

The initiation of new gene transcription during Xenopus gastrulation requires immediately preceding protein synthesis

1987 • 47 citations

Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I

1997 • 44 citations

Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1′ in Xenopus laevis embryos.

1996 • 44 citations

Mesoderm and endoderm differentiation in animal cap explants: identification of the HNF4-binding site as an activin A responsive element in the Xenopus HNF1α promoter

1996 • 42 citations

Combinatorial signaling in development

1994 • 23 citations

From mouse to frogs: identification and functional analyses of genes required for induction and patterning of the mesoderm

1996 • 7 citations