Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

TLR signaling

2007 • 1,296 citations

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

2005 • 1,196 citations

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

2006 • 1,029 citations

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

2005 • 973 citations

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

2005 • 901 citations

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

2005 • 886 citations

Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication

2006 • 862 citations

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

1996 • 828 citations

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

2005 • 788 citations

Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

2000 • 747 citations

Control of B-cell responses by Toll-like receptors

2005 • 732 citations

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

2006 • 661 citations

ATlr7translocation accelerates systemic autoimmunity in murine lupus

2006 • 611 citations

Activation of Autoreactive B Cells by CpG dsDNA

2003 • 523 citations

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8

2005 • 506 citations

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

2005 • 504 citations

Origin of dendritic cells in peripheral lymphoid organs of mice

2007 • 455 citations

Ligand-induced conformational changes allosterically activate Toll-like receptor 9

2007 • 445 citations

Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease

2007 • 373 citations

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE

2006 • 340 citations

Plasmacytoid Dendritic Cells Control TLR7 Sensitivity of Naive B Cells via Type I IFN

2005 • 334 citations

A y chromosome associated factor in strain bxsb producing accelerated autoimmunity and lymphoproliferation

1979 • 284 citations

Systemic lupus erythematosus: all roads lead to type I interferons

2006 • 275 citations

Association of Extensive Polymorphisms in the SLAM/CD2 Gene Cluster with Murine Lupus

2004 • 267 citations

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7

2005 • 259 citations

Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB−/− Mice

2002 • 250 citations

Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice

2006 • 243 citations

Toll‐like receptor 9 signaling protects against murine lupus

2005 • 219 citations

Systemic lupus erythematosus

2006 • 197 citations

Role of TLR9 in Anti-Nucleosome and Anti-DNA Antibody Production in lpr Mutation-Induced Murine Lupus

2006 • 162 citations

Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors

2007 • 155 citations

Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS

2005 • 134 citations

The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells

2003 • 84 citations

The Innate Functions of Dendritic Cells in Peripheral Lymphoid Tissues

2005 • 61 citations

Nucleic Acid-Sensing TLRs as Modifiers of Autoimmunity

2006 • 61 citations

Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus

2005 • 48 citations

Exogenous and Endogenous TLR Ligands Activate Anti-Chromatin and Polyreactive B Cells

2006 • 24 citations