A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

Regulation of angiogenesis by hypoxia: role of the HIF system

2003 • 2,404 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia

2003 • 1,276 citations

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

2001 • 1,025 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Tumour suppression by the human von Hippel-Lindau gene product

1995 • 705 citations

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

2003 • 683 citations

Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α

2003 • 583 citations

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

2002 • 386 citations

Evidence that reactive oxygen species do not mediate NF- B activation

2003 • 385 citations

Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants

2003 • 349 citations

Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress

2004 • 311 citations

Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways

2003 • 257 citations

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

2002 • 256 citations

AMP-activated Protein Kinase Activity Is Critical for Hypoxia-inducible Factor-1 Transcriptional Activity and Its Target Gene Expression under Hypoxic Conditions in DU145 Cells

2003 • 238 citations

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

2000 • 237 citations

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

2001 • 197 citations

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

2003 • 194 citations

The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen

2003 • 192 citations

Resistance of Mitochondrial DNA-depleted Cells against Cell Death

2004 • 169 citations

O ₂ Sensing in the Human Ductus Arteriosus

2002 • 166 citations

Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism

2003 • 165 citations

Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia

2002 • 138 citations

Oxygen‐dependent regulation of hypoxia‐inducible factors by prolyl and asparaginyl hydroxylation

2003 • 134 citations

Role of Redox Signaling in the Autonomous Proliferative Response of Endothelial Cells to Hypoxia

2003 • 129 citations

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells.

2002 • 128 citations

Dithiocarbamates and the redox regulation of cell death

1996 • 121 citations

Cell surface oxygen consumption by mitochondrial gene knockout cells

2004 • 109 citations

c-Jun NH2-Terminal Kinase Activation Contributes to Hypoxia-Inducible Factor 1α–Dependent P-Glycoprotein Expression in Hypoxia

2004 • 104 citations

NF-κB plays a key role in hypoxia-inducible factor-1–regulated erythropoietin gene expression

2002 • 93 citations

Reactive Oxygen Species–Mediated Signal Transduction in the Endothelium

2004 • 90 citations

Hypoxia, anoxia, and O₂ sensing: the search continues

2002 • 55 citations

Hypoxic induction of hypoxia-inducible factor-1α and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells

2002 • 49 citations

Nitric oxide signalling and cellular adaptations to changes in oxygenation

2004 • 40 citations

Inhibition of GSK3β by indirubins restores HIF‐1α accumulation under prolonged periods of hypoxia/anoxia

2004 • 40 citations

Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells

2002 • 30 citations

PERSPECTIVES

2003 • 1 citations