Reversion of age-related recognition memory impairment by iron chelation in rats

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

[49] Determination of carbonyl content in oxidatively modified proteins

1990 • 5,654 citations

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

1988 • 3,033 citations

Iron, brain ageing and neurodegenerative disorders

2004 • 1,737 citations

THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN

1958 • 1,401 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA

1991 • 1,012 citations

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

2003 • 963 citations

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

2000 • 744 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts

2002 • 703 citations

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

2003 • 613 citations

Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition

1999 • 579 citations

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

2002 • 563 citations

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

2001 • 381 citations

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

2003 • 370 citations

Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats

2001 • 348 citations

Oxidative stress and antioxidant therapy in Parkinson's disease

1996 • 342 citations

A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased Brains

1995 • 320 citations

Effect of aging on the blood-brain barrier

1988 • 297 citations

The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons

1991 • 297 citations

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer’s disease hippocampus by analytical microscopy at the subcellular level

2005 • 287 citations

The Hippocampus Supports both the Recollection and the Familiarity Components of Recognition Memory

2006 • 258 citations

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

2003 • 241 citations

Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain

1993 • 237 citations

Ironing Iron Out in Parkinson's Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6‐Hydroxydopamine and Iron Chelators, Desferal and VK‐28

2004 • 230 citations

Iron in the basal ganglia in Parkinson's disease

1999 • 216 citations

Treatment of Alzheimer’s Disease with Clioquinol

2001 • 214 citations

Oxidized protein degradation and repair in ageing and oxidative stress

2006 • 211 citations

Current Status of Metals as Therapeutic Targets in Alzheimer's Disease

2003 • 206 citations

Brain iron transport and neurodegeneration

2001 • 191 citations

MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease.

2000 • 191 citations

Neurotoxic methamphetamine regimen severely impairs recognition memory in rats

2003 • 184 citations

Increased Basal Ganglia Iron Levels in Huntington Disease

1999 • 183 citations

Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents

2001 • 178 citations

Brain iron deposition and the free radical-mitochondrial theory of ageing

2004 • 171 citations

The object recognition task in rats and mice: A simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity

2006 • 164 citations

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

1997 • 162 citations

Oxidative damage and age-related functional declines

2006 • 154 citations

Oxidative processes in Alzheimer's disease: the role of Aβ-metal interactions

2000 • 154 citations

Iron: A Pathological Mediator of Alzheimer Disease?

2002 • 147 citations

Studies on lipid peroxidation and protein oxidation in the aging brain

1995 • 140 citations

The role of transition metals in the pathogenesis of Parkinson's disease

1995 • 135 citations

Increasing striatal iron content associated with normal aging

1998 • 124 citations

Iron, neuroinflammation, and Alzheimer's disease

2005 • 122 citations

Age-related changes in the blood-brain barrier

1997 • 119 citations

Temporary inactivation reveals an essential role of the dorsal hippocampus in consolidation of object recognition memory

2006 • 117 citations

Neurodegenerative disease and iron storage in the brain

2004 • 117 citations

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat

2006 • 116 citations

Recognition memory impairment and brain oxidative stress induced by postnatal iron administration

2005 • 112 citations

Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats

2005 • 109 citations

Reversal of age-related deficits in object recognition memory in rats with l-deprenyl

2005 • 108 citations

Neonatal Iron Exposure Induces Neurobehavioural Dysfunctions in Adult Mice

1999 • 108 citations

Novel Chelators for Central Nervous System Disorders That Involve Alterations in the Metabolism of Iron and Other Metal Ions

2004 • 105 citations

Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat

2002 • 91 citations

Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period

2000 • 89 citations

Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss

2006 • 86 citations

Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration

2005 • 86 citations

Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants

2005 • 85 citations

Deferoxamine improves spatial memory performance following experimental brain injury in rats

1996 • 82 citations

Memory deficits in adult rats following postnatal iron administration

2001 • 78 citations

N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria

2000 • 72 citations

Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage

2006 • 70 citations

Neonatal iron exposure induces oxidative stress in adult Wistar rat

2001 • 66 citations

Brain iron in the ferrocene-loaded rat: Its chelation and influence on dopamine metabolism

1995 • 65 citations

Differential contributions of hippocampus, amygdala and perirhinal cortex to recognition of novel objects, contextual stimuli and stimulus relationships

2005 • 59 citations

MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice

2003 • 59 citations

Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism

2005 • 56 citations

Iron as the malignant spirit in successful ageing

2002 • 51 citations

Selegiline protects against recognition memory impairment induced by neonatal iron treatment

2005 • 48 citations

Effect of α-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity

2006 • 29 citations

Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration

2006 • 12 citations

Deleted Work

1955 • 0 citations