Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

2004 • 874 citations

Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture

1996 • 772 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Intranasal insulin improves memory in humans

2004 • 665 citations

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

2008 • 607 citations

Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype

2005 • 597 citations

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

2008 • 495 citations

Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia

2007 • 336 citations

The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons

1991 • 297 citations

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

2005 • 295 citations

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

2000 • 279 citations

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

2006 • 278 citations

Intravenous Tissue-Type Plasminogen Activator Therapy for Ischemic Stroke

2001 • 243 citations

Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

2004 • 227 citations

Delivery of interferon-β to the monkey nervous system following intranasal administration

2008 • 225 citations

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

1994 • 207 citations

Delivery of¹²⁵I-NGF to the Brain via the Olfactory Route

1997 • 193 citations

Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemiain Vivoandin Vitro

2002 • 187 citations

The role of iron neurotoxicity in ischemic stroke

2004 • 142 citations

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat

2006 • 116 citations

Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs

1995 • 112 citations

Emerging Medical and Surgical Management Strategies in the Evaluation and Treatment of Intracerebral Hemorrhage

2005 • 109 citations

Hypoxia-inducible factor 1α and erythropoietin upregulation with deferoxamine salvage after neonatal stroke

2005 • 105 citations

The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats

2004 • 87 citations

Deferoxamine improves spatial memory performance following experimental brain injury in rats

1996 • 82 citations

Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload

2006 • 80 citations

Polyol pathway mediates iron-induced oxidative injury in ischemic–reperfused rat heart

2008 • 79 citations

Direct access of drugs to the human brain after intranasal drug administration?

2003 • 78 citations

Acute iron poisoning.

1994 • 78 citations

Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1α and erythropoietin

2008 • 72 citations

Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage

2006 • 70 citations

Acute iron poisoning. Rescue with macromolecular chelators.

1989 • 63 citations

First human studies with a high-molecular-weight iron chelator

2000 • 58 citations

Reversion of age-related recognition memory impairment by iron chelation in rats

2007 • 57 citations

Percutaneous Clot Removal Devices in Acute Ischemic Stroke

2008 • 47 citations

EFFECTS OF DEFEROXAMINE-ACTIVATED HYPOXIA-INDUCIBLE FACTOR-1 ON THE BRAINSTEM AFTER SUBARACHNOID HEMORRHAGE IN RATS

2008 • 43 citations