Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

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Assay of proteins in the presence of interfering materials

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Signal transduction to hypoxia-inducible factor 1

2002 • 843 citations

Regulation of glut1 mRNA by Hypoxia-inducible Factor-1

2001 • 704 citations

O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

2004 • 684 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function

2004 • 459 citations

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

1994 • 448 citations

Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study

2002 • 396 citations

Glucose transporter expression in the central nervous system: relationship to synaptic function

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Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1987 • 263 citations

Tau phosphorylation and aggregation in Alzheimer's disease pathology

2006 • 255 citations

Induction of glucose transporter 1 expression through hypoxia-inducible factor 1α under hypoxic conditions in trophoblast-derived cells

2004 • 204 citations

GLUT-1 Expression in the Cerebra of Patients with Alzheimer’s Disease

1997 • 188 citations

Causes and Consequences of Disturbances of Cerebral Glucose Metabolism in Sporadic Alzheimer Disease: Therapeutic Implications

2004 • 166 citations

Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease

2002 • 156 citations

Glucose metabolism and Alzheimer's disease

2005 • 129 citations

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation

2006 • 128 citations

Concurrent alterations of O‐GlcNAcylation and phosphorylation of tau in mouse brains during fasting

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Functional Alterations in Alzheimerʼs Disease

1995 • 99 citations

Signal Transduction Cascades Associated with Oxidative Stress in Alzheimer's Disease

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Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5

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Glucose transport to the brain: A systems model

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Expression, regulation, and functional role of glucose transporters (GLUTs) in brain

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Redox state regulates HIF-1α and its DNA binding and phosphorylation in salmonid cells

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Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

2003 • 57 citations