Back to search

Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia

Data up to Jan 2025

Published2008
Citations84
References303

Total Citations Per Year

Abstract

References (303)

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Ischemic Cell Death in Brain Neurons

1999 • 2,974 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

2005 • 2,694 citations

Excitotoxic cell death

1992 • 2,307 citations

Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells

2005 • 2,049 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

2008 • 1,992 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins

1998 • 1,335 citations

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

2004 • 1,322 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

The many faces of CREB

2005 • 1,282 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial

2002 • 1,038 citations

The mitochondrion in apoptosis: how Pandora's box opens

2001 • 1,035 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Epidemiology of stroke

1992 • 1,008 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Apoptotic DNA Fragmentation

2000 • 885 citations

Central nervous system injury-induced immune deficiency syndrome

2005 • 856 citations

Apoptosis and Caspases in Neurodegenerative Diseases

2003 • 852 citations

Heat-shock protein 70 antagonizes apoptosis-inducing factor

2001 • 846 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

2003 • 838 citations

Calcium in Ischemic Cell Death

1998 • 818 citations

Ischemic tolerance and endogenous neuroprotection

2003 • 790 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Structural Basis for the Inhibition of Caspase-3 by XIAP

2001 • 763 citations

Free Radical Pathways in CNS Injury

2000 • 762 citations

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 • 754 citations

Two Distinct Pathways Leading to Nuclear Apoptosis

2000 • 737 citations

Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

2002 • 732 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

NXY-059 for the Treatment of Acute Ischemic Stroke

2007 • 719 citations

A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice

1999 • 716 citations

What is immune privilege (not)?

2006 • 708 citations

Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis

1998 • 702 citations

Molecular targets in cerebral ischemia for developing novel therapeutics

2007 • 695 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

1997 • 655 citations

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

2004 • 648 citations

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

2001 • 644 citations

Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment

2001 • 618 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

Salmonella induces macrophage death by caspase‐1‐dependent necrosis

2000 • 606 citations

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

2000 • 555 citations

Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

1998 • 554 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

2002 • 550 citations

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1999 • 544 citations

HIF1 and oxygen sensing in the brain

2004 • 539 citations

Numerous candidate plasticity-related genes revealed by differential cDNA cloning

1993 • 522 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

What is the blood–brain barrier (not)?

2006 • 497 citations

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

1999 • 495 citations

Mitochondria, the killer organelles and their weapons

2002 • 480 citations

Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia

1995 • 479 citations

Structural Basis of Caspase Inhibition by XIAP

2001 • 473 citations

Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress

2000 • 458 citations

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

1999 • 435 citations

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

2001 • 434 citations

Lysosomes revisited

1983 • 427 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

In VivoDelivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

2002 • 418 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

Induction of bcl-2 Expression by Phosphorylated CREB Proteins during B-Cell Activation and Rescue from Apoptosis

1996 • 410 citations

Prognostic Significance for Stroke of a Morning Pressor Surge and a Nocturnal Blood Pressure Decline

2005 • 396 citations

Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states

2003 • 394 citations

Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

1993 • 394 citations

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

2004 • 383 citations

XIAP: apoptotic brake and promising therapeutic target.

2001 • 380 citations

Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression

2001 • 373 citations

Tissue Plasminogen Activator Reduces Neurological Damage After Cerebral Embolism

1985 • 369 citations

Neuronal Nitric Oxide Synthase Activation and Peroxynitrite Formation in Ischemic Stroke Linked to Neural Damage

1999 • 365 citations

Gene expression during ER stress–induced apoptosis in neurons

2003 • 361 citations

Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy

2006 • 358 citations

Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway

2000 • 352 citations

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

2000 • 347 citations

NFκB-dependent signaling pathways

2002 • 340 citations

Matrix Metalloproteinase Expression After Human Cardioembolic Stroke

2001 • 334 citations

Caspases as treatment targets in stroke and neurodegenerative diseases

1999 • 327 citations

Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

2005 • 326 citations

Pathophysiology of Stroke: Lessons from Animal Models

2004 • 325 citations

Mitochondrial contributions to tissue damage in stroke

2002 • 320 citations

Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy

1997 • 308 citations

Neurodegenerative disorders and ischemic brain diseases.

2001 • 305 citations

Ca 2+ Signals and Neuronal Death in Brain Ischemia

2007 • 300 citations

Transcriptional oscillation of canonical clock genes in mouse peripheral tissues.

2004 • 297 citations

Expression of bcl-2 From a Defective Herpes Simplex Virus–1 Vector Limits Neuronal Death in Focal Cerebral Ischemia

1995 • 297 citations

Transient Ischemic Attacks Before Ischemic Stroke: Preconditioning the Human Brain?

2004 • 293 citations

Coenzyme Q10 Prevents Apoptosis by Inhibiting Mitochondrial Depolarization Independently of Its Free Radical Scavenging Property

2003 • 293 citations

Cell cycle regulation of neuronal apoptosis in development and disease

2004 • 293 citations

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

2007 • 290 citations

Involvement of apoptosis‐inducing factor in neuronal death after hypoxia‐ischemia in the neonatal rat brain

2003 • 288 citations

Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia

2006 • 287 citations

Estrogen Protects against Global Ischemia-Induced Neuronal Death and Prevents Activation of Apoptotic Signaling Cascades in the Hippocampal CA1

2002 • 284 citations

Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates

2003 • 284 citations

Bcl‐2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase‐3 activity

2003 • 283 citations

Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death

2004 • 278 citations

Activation of the Nuclear Factor-κB Is a Key Event in Brain Tolerance

2001 • 275 citations

Localization of Phosphorylated cAMP Response Element-Binding Protein in Immature Neurons of Adult Hippocampus

2002 • 269 citations

Neuronal death/survival signaling pathways in cerebral ischemia

2004 • 262 citations

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death

2000 • 255 citations

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

1997 • 254 citations

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

2001 • 252 citations

Hypoxia-associated Induction of Early Growth Response-1 Gene Expression

1999 • 250 citations

Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

2002 • 249 citations

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

1999 • 248 citations

Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in Rats

1998 • 246 citations

XIAP, the guardian angel

2001 • 246 citations

Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor

2001 • 244 citations

Specific Caspase Pathways Are Activated in the Two Stages of Cerebral Infarction

2001 • 243 citations

Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein

1997 • 237 citations

Neuroprotection in Cerebral Ischaemia: Facts and Fancies – The Need for New Approaches

2003 • 236 citations

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

2001 • 231 citations

Role of erythropoietin in the brain

2007 • 227 citations

Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.

1994 • 219 citations

Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase Activation

1998 • 219 citations

Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL

2005 • 212 citations

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

2001 • 211 citations

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury

2004 • 209 citations

Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats

2005 • 209 citations

CREB-Mediated Bcl-2 Protein Expression after Ischemic Preconditioning

2005 • 209 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

Evolution of Brain Infarction after Transient Focal Cerebral Ischemia in Mice

2000 • 205 citations

Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease

2000 • 205 citations

Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus

1999 • 205 citations

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’

1998 • 204 citations

CREB and cAMP response element‐mediated gene expression in the ischemic brain

2007 • 201 citations

Molecular machinery of the circadian clock in mammals

2002 • 201 citations

Characterizing the Target of Acute Stroke Therapy

1997 • 199 citations

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

2001 • 198 citations

Calcium, free radicals and excitotoxins in neuronal apoptosis

1998 • 195 citations

Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage

2007 • 191 citations

Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemiain Vivoandin Vitro

2002 • 187 citations

Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation

2006 • 186 citations

Circadian Variation in Stroke Onset: Identical Temporal Pattern in Ischemic and Hemorrhagic Events

2005 • 185 citations

Endogenous inhibitors of caspases.

1999 • 183 citations

Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury

2000 • 183 citations

Inhibitor of Apoptosis Proteins Are Substrates for the Mitochondrial Serine Protease Omi/HtrA2

2003 • 182 citations

Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury

2002 • 177 citations

Bid acts on the permeability transition pore complex to induce apoptosis

2000 • 174 citations

JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: Basal expression and induction by spreading depression and epileptic seizures

1993 • 174 citations

Action of Recombinant Human Apoptotic Endonuclease G on Naked DNA and Chromatin Substrates

2001 • 172 citations

Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo

1993 • 170 citations

Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus

2004 • 170 citations

Prolonged Activation of NF-κB Following Traumatic Brain Injury in Rats

1999 • 167 citations

Nuclear Translocation of Apoptosis-Inducing Factor after Focal Cerebral Ischemia

2004 • 167 citations

Experimental models for the investigation of brain ischemia

1998 • 165 citations

Translocation of Apoptosis-Inducing Factor in Vulnerable Neurons after Transient Cerebral Ischemia and in Neuronal Cultures after Oxygen-Glucose Deprivation

2003 • 159 citations

Ischemic neuronal death in the rat hippocampus: the calpain–calpastatin–caspase hypothesis

2003 • 157 citations

Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion

1995 • 156 citations

Neuroglobin: an endogenous neuroprotectant

2007 • 154 citations

Differential Neuroprotection by Cyclosporin A and FK506 Following Ischemia Corresponds with Differing Abilities to Inhibit Calcineurin and the Mitochondrial Permeability Transition

2002 • 154 citations

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

2003 • 151 citations

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

1997 • 147 citations

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

2007 • 141 citations

Patient Demographic and Clinical Features and Circadian Variation in Onset of Ischemic Stroke

2002 • 139 citations

Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study

2005 • 139 citations

Dual Role for Fas Ligand in the Initiation of and Recovery from Experimental Allergic Encephalomyelitis

1999 • 137 citations

Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death

2004 • 135 citations

Seizure Activity Results in a Rapid Induction of Nuclear Factor‐κB in Adult but Not Juvenile Rat Limbic Structures

1996 • 134 citations

Adenovirus‐Mediated Gene Transfer of Inhibitors of Apoptosis Proteins Delays Apoptosis in Cerebellar Granule Neurons

1999 • 129 citations

Some new prospects in the understanding of the molecular basis of the pathogenesis of stroke

2007 • 124 citations

Immediate early gene induction after neonatal hypoxia-ischemia

1993 • 121 citations

Apoptosis dominant in the periinfarct area of human ischaemic stroke—a possible target of antiapoptotic treatments

2005 • 120 citations

The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation

2005 • 120 citations

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP

2001 • 118 citations

Inhibition of Neuronal Apoptosis in Vitro and in Vivo Using TAT-Mediated Protein Transduction

2002 • 117 citations

TGF-β1 activates two distinct type I receptors in neurons

2005 • 116 citations

μ-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage

2000 • 115 citations

Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia

2005 • 115 citations

Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region

1999 • 114 citations

Distribution of the rhythm-related genes rPERIOD1, rPERIOD2, and rCLOCK, in the rat brain

2003 • 114 citations

Ischemia-mediated neuronal injury

1993 • 113 citations

Kainate-induced genes in the hippocampus: lessons from expression patterns

2001 • 111 citations

Bid-mediated Mitochondrial Pathway Is Critical to Ischemic Neuronal Apoptosis and Focal Cerebral Ischemia

2002 • 109 citations

Apoptosis: a guide for the perplexed

2002 • 109 citations

Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia

1999 • 109 citations

Genome-Wide Gene Expression Analysis for Induced Ischemic Tolerance and Delayed Neuronal Death following Transient Global Ischemia in Rats

2004 • 108 citations

Neuroprotection by Selective Nitric Oxide Synthase Inhibition at 24 Hours After Perinatal Hypoxia-Ischemia

2002 • 108 citations

Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity

1997 • 106 citations

Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1α (HIF-1α) protein following focal cerebral ischemia in rats

2006 • 105 citations

Immediate Early Gene Expression in Experimental Epilepsy

1993 • 104 citations

Lack of NF-κB p50 Exacerbates Degeneration of Hippocampal Neurons after Chemical Exposure and Impairs Learning

2002 • 102 citations

Microplasmin: A Novel Thrombolytic That Improves Behavioral Outcome After Embolic Strokes in Rabbits

2002 • 102 citations

Persistent phosphorylation of cyclic amp responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain

1999 • 100 citations

A caspase inhibitor blocks ischaemia‐induced delayed neuronal death in the gerbil

1998 • 100 citations

A “Protease Activation Cascade” in the Pathogenesis of Alzheimer's Disease

2000 • 99 citations

TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic–ischemic brain injury via inhibition of caspases and AIF

2005 • 98 citations

Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia

2001 • 96 citations

Bcl-2 Transfection via Herpes Simplex Virus Blocks Apoptosis-Inducing Factor Translocation after Focal Ischemia in the Rat

2004 • 95 citations

Endonuclease G is required for early embryogenesis and normal apoptosis in mice

2003 • 95 citations

CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region

2003 • 93 citations

Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats

1996 • 92 citations

IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo

2002 • 92 citations

Measurement of Membrane Permeability and the Permeability Transition of Mitochondria

2007 • 91 citations

Problems of cell death in neurodegeneration and Alzheimer's Disease

2001 • 91 citations

The Contribution of Apoptosis-inducing Factor, Caspase-activated DNase, and Inhibitor of Caspase-activated DNase to the Nuclear Phenotype and DNA Degradation during Apoptosis

2005 • 90 citations

Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia

2003 • 89 citations

Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis‐inducing factor, cytochrome c and caspase‐3 activation in neurons exposed to transient hypoglycemia

2003 • 85 citations

Mechanisms of mitochondrial membrane permeabilization

2000 • 85 citations

Of Rodents and Ungulates and Melatonin: Creating a Uniform Code for Darkness by Different Signaling Mechanisms

2001 • 82 citations

Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice

2005 • 79 citations

HIF‐1α reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion

2004 • 75 citations

Poly(ADP-Ribose) Polymerase Inhibition in Oxidant-Stressed Endothelial Cells Prevents Oncosis and Permits Caspase Activation and Apoptosis

1999 • 75 citations

Global Ischemia Induces Immediate-Early Genes Encoding Zinc Finger Transcription Factors

1996 • 73 citations

NF-κB protects neurons from ischemic injury after middle cerebral artery occlusion in mice

2006 • 72 citations

Neuroprotection in Transient Focal Cerebral Ischemia by Combination Drug Therapy and Mild Hypothermia

2003 • 71 citations

Interaction between XIAP and Smac/DIABLO in the Mouse Brain after Transient Focal Cerebral Ischemia

2003 • 70 citations

The Phosphodiesterase Inhibitor Rolipram Promotes Survival of Newborn Hippocampal Neurons After Ischemia

2007 • 70 citations

A Novel Immune-Based Therapy for Stroke Induces Neuroprotection and Supports Neurogenesis

2007 • 70 citations

Regulation of X-Chromosome-Linked Inhibitor of Apoptosis Protein in Kainic Acid-Induced Neuronal Death in the Rat Hippocampus

2001 • 69 citations

Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke

2004 • 67 citations

Failed Central Nervous System Regeneration: A Downside of Immune Privilege?

2005 • 67 citations

The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion

2006 • 65 citations

MR imaging of heat stroke: external capsule and thalamic T1 shortening and cerebellar injury.

2003 • 65 citations

Analysis of cell signalling in the rodent pineal gland deciphers regulators of dynamic transcription in neural/endocrine cells*

2001 • 63 citations

Pathophysiological role of calpain in experimental demyelination

1999 • 62 citations

Rapid and long-term induction of effector immediate early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain

2007 • 61 citations

Chapter 8 Measurement of membrane permeability and permeability transition of mitochondria

2001 • 60 citations

Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices

1995 • 59 citations

Developmental maturation of pineal gland function: synchronized CREM inducibility and adrenergic stimulation.

1995 • 58 citations

c-Jun and cyclin D1 proteins as mediators of neuronal death after a focal ischaemic insult

1997 • 58 citations

CREB family transcription factors inhibit neuronal suicide

2002 • 56 citations

Adrenomedullin expression is up-regulated by ischemia–reperfusion in the cerebral cortex of the adult rat

2002 • 55 citations

Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation

2004 • 53 citations

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

2001 • 52 citations

Neuronal protective effects of calcium antagonists in cerebral ischemia

1994 • 52 citations

Apoptosis, Necrosis, or Oncosis: What Is Your Diagnosis? A Report from the Cell Death Nomenclature Committee of the Society of Toxicologic Pathologists

1998 • 51 citations

HtrA2/Omi, a Sheep in Wolf's Clothing

2003 • 51 citations

Inhibition of Nitric Oxide Synthase byL-NAME Improves Ventricular Performance in Streptozotocin- diabetic Rats

1997 • 50 citations

Design of a Ruthenium−Cytochrome c Derivative To Measure Electron Transfer to the Radical Cation and Oxyferryl Heme in Cytochrome c Peroxidase

1996 • 49 citations

Circadian variation in stroke - a prospective hospital-based study

2005 • 47 citations

Nitric Oxide Donors Induce Neurotrophin-Like Survival Signaling and Protect Neurons against Apoptosis

2005 • 46 citations

Time-of-day affects expression of hippocampal markers for ischemic damage induced by global ischemia

2007 • 46 citations

Regulation of XIAP and Smac/DIABLO in the rat hippocampus following transient forebrain ischemia

2004 • 44 citations

Tissue plasminogen activator mediated blood–brain barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent

2005 • 44 citations

Oxidative Stress Is Associated With XIAP and Smac/DIABLO Signaling Pathways in Mouse Brains After Transient Focal Cerebral Ischemia

2004 • 44 citations

Motoneuron Resistance to Apoptotic Cell DeathIn VivoCorrelates with the Ratio between X-Linked Inhibitor of Apoptosis Proteins (XIAPs) and Its Inhibitor, XIAP-Associated Factor 1

2004 • 43 citations

Specificity of resistance to oxidative stress

2002 • 43 citations

CRE‐mediated gene transcription in the peri‐infarct area after focal cerebral ischemia in mice

2003 • 42 citations

Overexpression of Copper-Zinc Superoxide Dismutase Attenuates Acute Activation of Activator Protein-1 After Transient Focal Cerebral Ischemia in Mice

2001 • 41 citations

Effect of calpain on the composition and structure of postsynaptic densities

1995 • 41 citations

Postischemic Gene Transfer of Soluble Flt-1 Protects against Brain Ischemia with Marked Attenuation of Blood—Brain Barrier Permeability

2006 • 41 citations

N-methyl-d-aspartate receptor and L-type voltage-gated Ca2+ channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia

2002 • 40 citations

Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge

1998 • 39 citations

Key Note Lecture

2007 • 39 citations

Post-ischemic activation of caspase-3 in the rat hippocampus: evidence of an axonal and dendritic localisation

2003 • 39 citations

Entorhinal Cortex Lesion in the Mouse Induces Transsynaptic Death of Perforant Path Target Neurons

2004 • 37 citations

Function of BID – a Molecule of the bcl-2 Family – in Ischemic Cell Death in the Brain

2002 • 37 citations

Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus

1997 • 36 citations

Upregulation of Beclin 1 in the ischemic penumbra

2008 • 36 citations

Molecular Pathways in Cerebral Ischemia: Cues to Novel Therapeutic Strategies

2003 • 36 citations

Time course of circulatory and metabolic recovery of cat brain after cardiac arrest assessed by perfusion- and diffusion-weighted imaging and MR-spectroscopy

2003 • 36 citations

Regionally selective changes in brain lysosomes occur in the transition from young adulthood to middle age in rats

2000 • 35 citations

β2-Adrenergic receptor responsiveness of the calpain–calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia

2003 • 35 citations

Putative Role of Calpain in the Pathophysiology of Experimental Optic Neuritis

1998 • 34 citations

Potential role of neuroprotective agents in the treatment of patients with acute ischemic stroke

2003 • 33 citations

Plasticity- and neurodegeneration-linked cyclic-AMP responsive element modulator/inducible cyclic-AMP early repressor messenger RNA expression in the rat brain

1998 • 32 citations

Induction of cAMP response element modulator (CREM) and inducible cAMP early repressor (ICER) expression in rat brain by uncompetitive N-methyl-D-aspartate receptor antagonists.

2000 • 32 citations

Mechanism of Action of a New Component of the Ca2+-Dependent Proteolytic System in Rat Brain: The Calpain Activator

1998 • 31 citations

A Dopamine D4 Receptor Antagonist Attenuates Ischemia-Induced Neuronal Cell Damage via Upregulation of Neuronal Apoptosis Inhibitory Protein

2005 • 30 citations

Proximal occlusion of the middle cerebral artery in C57Black6 mice: relationship of patency of the posterior communicating artery, infarct evolution, and animal survival

2004 • 28 citations

Altered protein expression levels of Fas/CD95 and Fas Ligand in differentially vulnerable brain areas in rats after global cerebral ischemia

2003 • 28 citations

Role of mitochondrial proteins for neuronal cell death after focal cerebral ischemia

2004 • 28 citations

Hypothermic Modulation of Cerebral Ischemic Injury during Cardiopulmonary Bypass in Pigs

1998 • 27 citations

Thiopental and phenytoin by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 minutes in dogs. An exploratory study

2001 • 26 citations

The Calpain Proteolytic System in Neonatal Hypoxic‐Ischemiaa

1997 • 25 citations

Induction and redistribution of XAF1, a new antagonist of XIAP in the rat brain after transient focal ischemia

2005 • 25 citations

Role of endonuclease G in neuronal excitotoxicity in mice

2004 • 23 citations

Inhibiting caspase-9 after injury reduces hypoxic ischemic neuronal injury in the cortex in the newborn rat

2003 • 23 citations

A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: effects on transient cerebral ischemia in cats.

2002 • 21 citations

Rat middle cerebral artery occlusion: Correlations between histopathology, T2-weighted magnetic resonance imaging, and behavioral indices

2001 • 20 citations

Long‐term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors

2001 • 19 citations

Brain Damage Caused by Ischemia: Pathophysiological and Pharmacological Aspects

1993 • 18 citations

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

2004 • 15 citations

Synergetic Effects of Caspase 3 and μ-Calpain in XIAP-Breakdown upon Focal Cerebral Ischemia

2007 • 15 citations

[Mitochondrial control of apoptosis].

2001 • 15 citations

Increased expression of genes that control ionic homeostasis, second messenger signaling and metabolism in the carotid plaques from patients with symptomatic stroke

2005 • 10 citations

Development and death of neurons: sealed by a common fate?

2002 • 7 citations

Synthesis and evaluation of novel dipeptidyl benzoyloxymethyl ketones as caspase inhibitors

2005 • 6 citations

The effects of monobromobimane on neuronal cell death in the hippocampus after transient global cerebral ischemia in rats

2004 • 5 citations

Cited By (0)

Loading...
Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in… (2008) – Progress in Neurobiology | Metascience Observatory Explorer