Growth Factors in Inflammatory Bowel Disease

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Hepatogastroenterology

2012 • 2,160 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 1,203 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein

1996 • 498 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1997 • 466 citations

Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

1990 • 465 citations

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

1998 • 446 citations

Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β

1993 • 446 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.

1989 • 420 citations

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway.

1994 • 420 citations

TGF-β receptor signaling

1997 • 417 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1996 • 388 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1998 • 368 citations

Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.

1998 • 362 citations

Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein

1995 • 342 citations

Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology

1995 • 329 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Effect of growth hormone, glutamine, and diet on adaptation in short- bowel syndrome: A randomized, controlled study

1997 • 306 citations

Discovery of a New Mechanism and Development of Angiogenic Therapy That Accelerates Healing

1991 • 282 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

Expression of basic fibroblast growth factor in normal human tissues.

1990 • 258 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats

1996 • 257 citations

Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease

1993 • 256 citations

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

1996 • 254 citations

Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2

1997 • 252 citations

Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

1993 • 252 citations

Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration

1995 • 252 citations

The met Proto-Oncogene Receptor and Lumen Formation

1992 • 246 citations

EGF, TGF-a, and EGF-R in Human Colorectal Adenocarcinoma

1998 • 243 citations

Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues

1990 • 228 citations

Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells.

1989 • 219 citations

Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways.

1991 • 219 citations

Expression of Hepatocyte Growth Factor mRNA in regenerating rat liver after partial hepatectomy

1991 • 219 citations

Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium.

1994 • 209 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Hepatocyte growth factor has potent anti‐proliferative activity in various tumor cell lines

1991 • 207 citations

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

1998 • 205 citations

Fibroblast growth factors and their receptors

1997 • 204 citations

Platelets and inflammation: Role of platelet-derived growth factor, adhesion molecules and histamine

1997 • 201 citations

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

1997 • 197 citations

Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach

1995 • 179 citations

Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage.

1996 • 175 citations

Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species

1992 • 171 citations

Distribution and release of epidermal growth factor in man.

1989 • 161 citations

Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

1998 • 156 citations

Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I

1997 • 156 citations

Orally administered IGF-I increases intestinal mucosal growth in formula-fed neonatal pigs

1996 • 155 citations

FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation

1998 • 149 citations

Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor.

1992 • 148 citations

Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3.

1994 • 148 citations

Epidermal Growth Factor Receptor of the Intestinal Enterocyte

1989 • 146 citations

Factors Involved in the Differentiation of TGF-β-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-γ Have Opposing Effects, While TGF-β Positively Regulates Its Own Production

1998 • 145 citations

Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach.

1992 • 143 citations

Localization of transforming growth factor β1 and its latent binding protein in human chronic pancreatitis

1995 • 142 citations

Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors.

1995 • 142 citations

Protective effect of epidermal growth factor in an experimental model of colitis in rats

1994 • 140 citations

Prognostic factors in gastric cancer

1997 • 139 citations

Homomeric interactions between type II transforming growth factor-beta receptors.

1994 • 137 citations

Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats

1996 • 136 citations

Truncated and native insulinlike growth factor I enhance mucosal adaptation after jejunoileal resection

1992 • 135 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

Increased production of transforming growth factor α following acute gastric injury

1992 • 133 citations

Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2

1997 • 132 citations

Expression of transforming growth factor alpha messenger rna in the normal and neoplastic gastro‐intestinal tract

1989 • 132 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2*

1997 • 131 citations

Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease

1996 • 129 citations

Altered Transforming Growth Factor β Signaling in Epithelial Cells when Ras Activation Is Blocked

1996 • 128 citations

Mice lacking transforming growth factor alpha have an increased susceptibility to dextran sulfate-induced colitis

1997 • 127 citations

Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor

1998 • 125 citations

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

1997 • 123 citations

Intestinal response to growth factors administered alone or in combination with human [Gly²]glucagon-like peptide 2

1997 • 122 citations

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.

1993 • 122 citations

Increased epithelial cell proliferation in the colon of patients with acromegaly.

1996 • 119 citations

Butyrate inhibits colon carcinoma cell growth through two distinct pathways

1998 • 118 citations

Transforming growth factor α disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice

1995 • 115 citations

Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells

1998 • 112 citations

Combined Intestinal Trefoil Factor and Epidermal Growth Factor is Prophylactic against Indomethacin-Induced Gastric Damage in the Rat

1995 • 112 citations

Transforming growth factor β1 selectively augments collagen synthesis by human intestinal smooth muscle cells

1990 • 111 citations

Insulin-Like Growth Factors and the Developing and Mature Rat Small Intestine: Receptors and Biological Actions

1990 • 110 citations

Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.

1996 • 109 citations

Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract.

1992 • 107 citations

Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.

1992 • 107 citations

Specific receptors for epidermal growth factor in rat intestinal microvillus membranes

1988 • 107 citations

Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer

1997 • 107 citations

Why is epidermal growth factor present in the gut lumen?

1996 • 107 citations

In Vivo Radioprotective Effects of Angiogenic Growth Factors on the Small Bowel of C3H Mice

1998 • 105 citations

Insulin like growth factor-I, insulin like growth factor binding protein-1, and insulin in childhood Crohn's disease.

1993 • 103 citations

Trefoil Peptide Gene Expression in Gastrointestinal Epithelial Cells in Inflammatory Bowel Disease

1992 • 103 citations

Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo

1997 • 102 citations

Secretion of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 by intestinal epithelial (IEC-6) cells: implications for autocrine growth regulation.

1992 • 98 citations

Stimulation of transforming growth factor β1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis

1998 • 96 citations

Insulin-like growth factor-I and its N-terminal modified analogues induce marked gut growth in dexamethasone-treated rats

1992 • 92 citations

A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms

1997 • 89 citations

Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells.

1998 • 87 citations

Nonmitogenic actions of growth factors: an integrated view of their role in intestinal physiology and pathophysiology.

1997 • 87 citations

Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.

1997 • 87 citations

Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects

1998 • 86 citations

Estrogen Receptor α and β Expression in Upper Gastrointestinal Tract with Regulation of Trefoil Factor Family 2 mRNA Levels in Ovariectomized Rats

1997 • 84 citations

TGF-β1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression

1998 • 83 citations

Cytokine mRNA Expression in Intestine from Normal and Inflammatory Bowel Disease Patients

1993 • 80 citations

Adenovirus-mediated Transfer of a Truncated Transforming Growth Factor-β (TGF-β) Type II Receptor Completely and Specifically Abolishes Diverse Signaling by TGF-β in Vascular Wall Cells in Primary Culture

1996 • 80 citations

Insulin-like Growth Factor-I Partially Attenuates Colonic Damage in Rats with Experimental Colitis Induced by Oral Dextran Sulphate Sodium

1998 • 79 citations

Inward growth of colonic adenomatous polyps

1996 • 78 citations

TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice.

1997 • 77 citations

Reduced susceptibility of mice overexpressing transforming growth factor α to dextran sodium sulphate induced colitis

1998 • 77 citations

Aspects of the biology of regeneration and repair in the human gastrointestinal tract

1998 • 74 citations

Modulation of monocyte type I transforming growth factor-beta receptors by inflammatory stimuli.

1991 • 72 citations

Enhancement of intestinal adaptation by hepatocyte growth factor

1998 • 71 citations

Serum basic fibroblast growth factor in pediatric Crohn's disease. Implications for wound healing.

1997 • 68 citations

Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta.

1996 • 68 citations

Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation.

1998 • 68 citations

Regulation of Insulin, Epidermal Growth Factor, and Transforming Growth Factor-α Levels by Growth Factor-Degrading Enzymes*

1991 • 65 citations

Effect of epidermal growth factor on experimental colitis in the rat.

1993 • 64 citations

IGF-I induces collagen and IGFBP-5 mRNA in rat intestinal smooth muscle

1997 • 63 citations

Differential Changes in Free and Total Insulin-Like Growth Factor I after Major, Elective Abdominal Surgery: The Possible Role of Insulin-Like Growth Factor-Binding Protein-3 Proteolysis¹

1998 • 63 citations

Spatial and Temporal Patterns of Expression of Epidermal Growth Factor, Transforming Growth Factor Alpha and Transforming Growth Factor Beta 1-3 and Their Receptors in Mouse Jejunum after Radiation Treatment

1997 • 62 citations

GH elevates serum IGF-I levels but does not alter mucosal atrophy in parenterally fed rats

1997 • 61 citations

The ulceration‐associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland

1994 • 61 citations

Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells.

1997 • 61 citations

Human serum does contain a high molecular weight hepatocyte growth factor: Studies pre- and post-hepatic resection

1986 • 60 citations

Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression.

1990 • 60 citations

Nonsteroidal Anti-inflammatory Drugs May Delay the Repair of Gastric Mucosa by Suppressing Prostaglandin-Mediated Increase of Hepatocyte Growth Factor Production

1998 • 60 citations

Beneficial effects of insulin-like growth factor I on epithelial structure and function in parenterally fed rat jejunum

1996 • 59 citations

INSULIN-LIKE GROWTH FACTOR-I IMPROVES MUCOSAL STRUCTURE AND FUNCTION IN TRANSPLANTED RAT SMALL INTESTINE

1995 • 59 citations

Association of transforming growth factor alpha (TGFA) and its precursors with malignant change in Barrett's epithelium: Biological and clinical variables

1995 • 59 citations

Resection-induced colonic adaptation is augmented by IGF-I and associated with upregulation of colonic IGF-I mRNA

1995 • 58 citations

Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers

1997 • 58 citations

Effects of Insulin-like Growth Factor-I Administration on Radiation Enteritis in Rats

1997 • 57 citations

Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer.

1997 • 57 citations

Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes

1995 • 56 citations

Characterization of a Putative Receptor for Intestinal Trefoil Factor in Rat Small Intestine: Identification byin SituBinding and Ligand Blotting

1997 • 55 citations

Serum levels of transforming growth factor alpha in gastrointestinal cancer patients.

1995 • 55 citations

Epidermal Growth Factor Receptors in Isolated Adult Mouse Intestinal Cells: Studiesin Vivoand in Organ Culture*

1985 • 55 citations

Increased expression of transforming growth factor α precursors in acute experimental colitis in rats

1997 • 55 citations

Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine

1997 • 53 citations

Expression of Epidermal Growth Factor and Transforming Growth Factor Alpha during Ulcer Healing: Time Sequence Study

1997 • 53 citations

Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel diseas

1995 • 52 citations

Autocrine regulation of growth in cultured human intestinal muscle by growth factors

1997 • 52 citations

Expression of transforming growth factor alpha, epidermal growth factor receptor and epidermal growth factor in precursor lesions to gastric carcinoma

1995 • 52 citations

Trophic action of local intraileal infusion of insulin-like growth factor I: polyamine dependence

1992 • 51 citations

Growth control mechanisms in normal and transformed intestinal cells

1998 • 51 citations

Expression of a human hepatocyte growth factor/scatter factor cDNA in MDCK epithelial cells influences cell morphology, motility, and anchorage-independent growth

1992 • 51 citations

Insulin‐like Growth Factor‐I Prevents Gut Atrophy and Maintains Intestinal Integrity in Septic Rats

1995 • 50 citations

Keratinocyte growth factor promotes healing of left-sided colon anastomoses

1998 • 50 citations

cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis

1996 • 49 citations

Effects of urogastrone-epidermal growth factor on intestinal brush border enzymes and mitotic activity.

1991 • 49 citations

Fasting Prevents Experimental Murine Colitis Produced by Dextran Sulfate Sodium and Decreases Interleukin-1β and Insulin-Like Growth Factor I Messenger Ribonucleic Acid¹

1997 • 49 citations

Growth factor mRNA expression in normal colorectal mucosa and in uninvolved mucosa from ulcerative colitis patients

1996 • 49 citations

Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats

1997 • 48 citations

Oxidative Damage and Transforming Growth Factor β1 Expression in Pretumoral and Tumoral Lesions of Human Intestine

1997 • 46 citations

Influence of Orally Administered Epidermal Growth Factor on Normal and Damaged Intestinal Mucosa in Rats

1993 • 45 citations

Effects of Insulin-Like Growth Factors I and II on Growth and Differentiation of Transplanted Rat Embryos and Fetal Tissues*

1989 • 45 citations

Ulceration Induces a Novel Epidermal Growth Factor-Secreting Cell Lineage in Human Gastrointestinal Mucosa

1990 • 42 citations

Some Physicochemical Properties of Ribonucleoprotein from Rat Liver Microsomes

1962 • 42 citations

Expression of antisense epidermal growth factor receptor RNA downmodulates the malignant behavior of human colon cancer cells

1995 • 42 citations

Induction of EGF-receptor tyrosine kinase during early reparative phase of gastric mucosa and effects of aging.

1995 • 42 citations

Constitutive Insulin-like Growth Factor-II Expression Interferes with the Enterocyte-like Differentiation of CaCo-2 Cells

1996 • 41 citations

Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage

1998 • 41 citations

Increased expression of EGFR in gastric mucosa of aged rats

1997 • 41 citations

Hepatocyte growth factor enhances intestinal mucosal cell function and mass in vivo

1997 • 40 citations

Transforming Growth Factor- and Epidermal Growth Factor Activate Mitogen-Activated Protein Kinase and Its Substrates in Intestinal Epithelial Cells

1995 • 39 citations

Germ-free and barrier-raised TGF beta 1-deficient mice have similar inflammatory lesions.

1997 • 38 citations

Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or motility

1997 • 37 citations

Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells

1997 • 37 citations

Up-regulation of insulinlike growth factor I binding sites in experimental colitis in rats

1995 • 37 citations

Distribution of basic fibroblast growth factor binding sites in various tissue membrane preparations from adult guinea pig

1989 • 36 citations

Gastric lesions in transforming growth factor beta-1 heterozygous mice.

1996 • 36 citations

Cytokine regulation of fibroblast growth factor receptor 3 IIIb in intestinal epithelial cells

1997 • 36 citations

Influence of Luminal Hepatocyte Growth Factor on Small Intestine Mucosain Vivo

1997 • 35 citations

Epidermal growth factor expression in human colon and colon carcinomas: Anti‐sense epidermal growth factor receptor rna down‐regulates the proliferation of human colon cancer cells

1995 • 34 citations

Processing of epidermal growth factor by suckling and adult rat intestinal cells

1986 • 34 citations

A comparison of the effect of growth factors on intestinal function and structure in short bowel syndrome

1997 • 34 citations

Expression of insulin-like growth factor-II and insulin-like growth factor binding proteins during Caco-2 cell proliferation and differentiation

1996 • 33 citations

Inhibition of tumor cell kinetics and serum insulin growth factor I levels by octreotide in colorectal cancer patients

1997 • 33 citations

Epidermal Growth Factor and Transforming Growth Factor Alpha in Duodenal Ulcer and Non-Ulcer Dyspepsia Patients before and afterHelicobacter pyloriEradication

1998 • 33 citations

Modulation of histamine release in the hypothalamus by nitric oxide

1997 • 32 citations

Beneficial effects of growth hormone combined with parenteral nutrition in the management of inflammatory bowel disease: An experimental study

1997 • 32 citations

Epidermal growth factor-related peptides as targets for experimental therapy of human colon carcinoma.

1998 • 31 citations

Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

1996 • 31 citations

Amphiregulin anti‐sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line

1995 • 30 citations

Increased expression of transforming growth factor-beta1 during gastric ulcer healing in rats.

1997 • 30 citations

Trefoil Peptide Gene Expression in Small Intestinal Crohnʼs Disease and Dietary Adaptation

1993 • 29 citations

Expression of amphiregulin in human gastric cancer cell lines

1995 • 29 citations

Secretion of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 by intestinal epithelial (IEC-6) cells: implications for autocrine growth regulation

1992 • 29 citations

Expression of amphiregulin in human gastric cancer cell lines

1995 • 28 citations

Differential Changes in Free and Total Insulin-Like Growth Factor I after Major, Elective Abdominal Surgery: The Possible Role of Insulin-Like Growth Factor-Binding Protein-3 Proteolysis

1998 • 28 citations

Up-regulation of transforming growth factor α binding sites in experimental rabbit colitis

1995 • 28 citations

Identification and evaluation of the role of endogenous tyrosine kinases in azoxymethane induction of proliferative processes in the colonic mucosa of rats

1995 • 27 citations

Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2

1997 • 27 citations

Can the intestine adapt to a changing environment?

1997 • 26 citations

Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats

1996 • 25 citations

Azoxymethane enhances ligand-induced activation of EGF receptor tyrosine kinase in the colonic mucosa of rats

1996 • 23 citations

Urogastrone Reduces Gut Atroprhy during Parenteral Alimentation

1990 • 23 citations

Matrix alters the proliferative response of enterocytes to growth factors

1996 • 23 citations

Effects of Insulin-Like Growth Factor I (IGF-I) on the Small Intestine: A Comparison between Oral and Subcutaneous Administration in the Weaned Rat

1997 • 23 citations

Role of heparin‐binding EGF‐related peptides in proliferation and apoptosis of activated ras ‐stimulated intestinal epithelial cells

1997 • 22 citations

Developmental regulation of transforming growth factor β-mediated collagen synthesis in human intestinal muscle cells

1996 • 20 citations

Stimulation of Intestinal Growth Is Associated with Increased Insulin-Like Growth Factor-Binding Protein 5 mRNA in the Jejunal Mucosa of Insulin-like Growth Factor-I-Treated Parenterally Fed Rats

1997 • 20 citations

Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activatedras-stimulated intestinal epithelial cells

1997 • 19 citations

Induction of plasma hepatocyte growth factor in acute colitis of mice

1997 • 19 citations

Heregulin-dependent autocrine loop regulates growth of K-ras but not erbB-2 transformed rat thyroid epithelial cells

1998 • 17 citations

Trefoil peptides: what are they and what do they do?

1997 • 17 citations

The Influence ofHelicobacter pyloriEradication on the Gastric Mucosal Content of Epidermal Growth Factor, Transforming Growth Factor-a, and Their Common Receptor

1998 • 17 citations

Effects of epidermal growth factor and glutamine-supplemented parenteral nutrition on the small bowel of septic rats

1992 • 16 citations

Colon goblet cells lose proliferative response to TGFα as they differentiate

1995 • 16 citations

The kinetic organization of the ulcer-associated cell lineage (UACL): delineation of a novel putative stem-cell region.

1994 • 16 citations

Regional differences in gastrointestinal processing and absorption of epidermal growth factor in suckling rats

1991 • 16 citations

Fasting Prevents Experimental Murine Colitis Produced by Dextran Sulfate Sodium and Decreases Interleukin-1 and Insulin-Like Growth Factor I Messenger Ribonucleic Acid

1997 • 16 citations

Growth Markers in the Human Gastric Mucosa During Adaptation to Continued Aspirin Administration

1996 • 15 citations

Production of epithelial cell growth factors by lamina propria mononuclear cells.

1992 • 15 citations

Epidermal growth factor (hEGF) has no effect on murine intestine epithelial damage and regeneration after melphalan

1985 • 15 citations

Oral Transforming Growth Factor-α Enhances Jejunal Mucosal Recovery and Electrical Resistance in Piglet Rotavirus Enteritis

1995 • 14 citations

Increased Susceptibility to N‐Nitrosomethylurea Gastric Carcinogenesis in Transforming Growth Factor α Transgenic Mice with Gastric Hyperplasia

1995 • 14 citations

Detection of insulin-like growth factor-I and transforming growth factor-β in whole gut lavage fluid: a novel method of studying intestinal fibrosis

1997 • 11 citations

Effects of insulin-like growth factor-1 on endotoxin translocation in burned rats receiving total parenteral nutrition

1997 • 11 citations

Changes in Mucosal Levels of Transforming Growth Factor-α from the Oxyntic Region and Ulcer Site during Duodenal Ulcer Healing with Ranitidine or Sucralfate

1998 • 9 citations

ALTERED EXPRESSION OF TGFα AND TGFβ1 IN THE MUCOSA OF THE FUNCTIONING PELVIC ILEAL POUCH

1996 • 8 citations

Transforming growth factor-alpha (TGF-alpha) levels in human proximal gastrointestinal epithelium. Effect of mucosal injury and acid inhibition.

1997 • 8 citations

Vascular endothelial growth factor (VEGF) enhances intestinal epithelial barrier formation: Potential role for intracellular cyclic-AMP

1998 • 3 citations