Differential Changes in Free and Total Insulin-Like Growth Factor I after Major, Elective Abdominal Surgery: The Possible Role of Insulin-Like Growth Factor-Binding Protein-3 Proteolysis¹

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

Insulin-like growth factors I and II in healthy man.

1989 • 513 citations

Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*

1990 • 368 citations

Free insulin-like growth factors in human obesity

1995 • 350 citations

Evidence of Enzymatic Degradation of Insulin-Like Growth Factor-Binding Proteins in the 150K Complex during Pregnancy*

1990 • 349 citations

Free insulin‐like growth factors (IGF‐I and IGF‐II) in human serum

1994 • 310 citations

Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II.

1995 • 277 citations

INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS

1991 • 262 citations

Characterization of the Acid-Labile Subunit of the Growth Hormone-Dependent Insulin-Like Growth Factor Binding Protein Complex*

1988 • 239 citations

Protein and Energy Metabolism with Biosynthetic Human Growth Hormone after Gastrointestinal Surgery

1987 • 225 citations

Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice.

1995 • 197 citations

In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells.

1994 • 184 citations

Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery.

1992 • 172 citations

Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin-like growth factor binding protein 3 protease

1996 • 162 citations

A Simple Assay for Proteolysis of IGFBP-3

1991 • 149 citations

The induction of specific proteases for insulin-like growth factor-binding proteins following major heart surgery

1992 • 105 citations

Recombinant human insulin-like growth factor (IGF)-binding protein-1 inhibits somatic growth stimulated by IGF-I and growth hormone in hypophysectomized rats.

1994 • 74 citations

Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum.

1992 • 73 citations

The differential regulation of the circulating levels of the insulin‐like growth factors and their binding proteins (IGFBP) 1, 2 and 3 after elective abdominal surgery

1996 • 73 citations

Administration of human recombinant insulin‐like growth factor‐I to patients following major gastrointestinal surgery

1992 • 65 citations

Proteolysis of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in 150-kilodalton IGFBP complexes by a cation-dependent protease activity in adult rat serum promotes the release of bound IGF-I.

1996 • 55 citations

Repeated Administration of Recombinant Human Insulin-Like Growth Factor-I in Patients After Gastric Surgery

1995 • 52 citations

INSULIN-LIKE GROWTH FACTOR (IGF) BINDING PROTEIN-3 IN PREGNANCY SERUM BINDS NATIVE IGF-I BUT NOT IODO-IGF-L

1991 • 50 citations

Serum free insulin-like growth factor-I in growth hormone-deficient adults before and after growth hormone replacement

1997 • 32 citations

Pharmacokinetic Profile of Recombinant Human Insulin‐Like Growth Factor I Given Subcutaneously in Normal Subjects

1991 • 29 citations

Free and total insulin-like growth factors and insulin-like growth factor binding proteins during 14 days of growth hormone administration in healthy adults

1996 • 29 citations

Growth hormone treatment after abdominal surgery decreased carbohydrate oxidation and increased fat oxidation in patients with total parenteral nutrition

1993 • 28 citations

No Effect of Growth Hormone on Serum Insulin-Like Growth Factor Binding Protein-3 Proteolysis¹

1998 • 25 citations

Improved Cumulated Nitrogen Balance after Administration of Recombinant Human Growth Hormone in Patients Undergoing Gastrointestinal Surgery

1994 • 17 citations

THE EFFECT OF RECOMBINANT GROWTH HORMONE ON NITROGEN BALANCE IN MALNOURISHED PATIENTS AFTER MAJOR ABDOMINAL SURGERY

1995 • 15 citations