Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction

1989 • 254 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor-β1 and phorbol ester occurs through the same target sequences

1989 • 185 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1993 • 170 citations

Transforming growth factor‐β inhibits interleukin‐12‐induced production of interferon‐γ by natural killer cells: A role for transforming growth factor‐β in the regulation of T cell‐independent resistance to Toxoplasma gondii

1995 • 149 citations

Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line

1996 • 137 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

TGF-beta is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans.

1995 • 93 citations

Opposing effects of TGF-beta 2 on the Th1 cell development of naive CD4+ T cells isolated from different mouse strains.

1995 • 60 citations

Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation

1985 • 59 citations