Regulation of Insulin, Epidermal Growth Factor, and Transforming Growth Factor-α Levels by Growth Factor-Degrading Enzymes*

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

1989 • 528 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Internalization of polypeptide hormones

1980 • 207 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Human Insulin-Degrading Enzyme Shares Structural and Functional Homologies with E. coli Protease III

1988 • 141 citations

Rat myoblast fusion requires metalloendoprotease activity

1983 • 140 citations

Inhibitors of glucagon inactivationEffect on glucagon-receptor interactions and glucagon-stimulated adenylate cyclase activity in liver cell membranes

1974 • 118 citations

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease.

1986 • 118 citations

Degradation products of insulin generated by hepatocytes and by insulin protease.

1988 • 95 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Dual pathways for the intracellular processing of insulin. Relationship between retroendocytosis of intact hormone and the recycling of insulin receptors.

1985 • 92 citations

Insulin processing by the liver.

1982 • 65 citations

Divergent effects of epidermal growth factor and transforming growth factors on a human endometrial carcinoma cell line.

1987 • 63 citations

Cloning and Expression of the cDNA for aDrosophilaInsulin-Degrading Enzyme

1990 • 62 citations

Evidence for Two Independent Pathways of Insulin-Receptor Internalization in Hepatocytes and Hepatoma Cells

1988 • 57 citations

Attenuated Processing of Epidermal Growth Factor in the Face of Marked Degradation of Transforming Growth Factor-α

1989 • 56 citations

Metalloendoprotease Inhibitors Which Block the Differentiation of L6 Myoblasts Inhibit Insulin Degradation by the Endogenous Insulin-degrading Enzyme

1989 • 54 citations

Intracellular processing of epidermal growth factor. I. Acidification of 125I-epidermal growth factor in intracellular organelles.

1984 • 54 citations

An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.

1989 • 53 citations

Dual pathways for epidermal growth factor processing after receptor‐mediated endocytosis

1982 • 52 citations

Calcitonin binding and degradation by two cultured human breast cancer cell lines (MCF 7 and T 47D)

1981 • 51 citations

Active site directed irreversible inhibition of thermolysin

1978 • 50 citations

Intracellular processing of epidermal growth factor. II. Intracellular cleavage of the COOH-terminal region of 125I-epidermal growth factor.

1984 • 49 citations

Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster

1988 • 42 citations

Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway

1989 • 39 citations

Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.

1986 • 37 citations

Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites

1989 • 31 citations

Uptake and degradation of insulin and α2-macroglobulin-trypsin complex in rat adipocytes. Evidence for different pathways

1985 • 25 citations

Characterization of an insulin degrading enzyme from cultured human lymphocytes

1985 • 25 citations

Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster.

1988 • 24 citations

Effects of Lysosomal Inhibitors on 125I-Insulin and 125I-Asialofetuin Degradation by the Isolated, Perfused Rat Liver and Isolated Rat Hepatocytes

1985 • 20 citations

Cell Type-Specific Variability of Bacitracin's Effects on Insulin Binding and Intracellular Accumulation

1986 • 18 citations