Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

Growth Factors and Cancer

1991 • 2,044 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats

1984 • 1,153 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

1991 • 698 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

Purification and subunit structure of hepatocyte growth factor from rat platelets

1987 • 557 citations

Mechanism of met oncogene activation

1986 • 551 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

Tyrosine kinase receptor indistinguishable from the c-met protein

1989 • 496 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

Hepatocyte growth factor receptor and the c-met oncogene Bottaro DP, Rubin JS, Faletto DL, Chan AM-L, Kmiecik TE, Vande Woude GF, Aaronson SA. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802?804

1991 • 434 citations

An epithelial scatter factor released by embryo fibroblasts

1985 • 368 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

Structure and function of hepatocyte growth factor

1991 • 307 citations

Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells

1991 • 259 citations

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE

1991 • 253 citations

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

1988 • 242 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

1988 • 183 citations

c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.

1991 • 170 citations

C-terminal truncated forms of Met, the hepatocyte growth factor receptor.

1991 • 165 citations

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

1988 • 139 citations

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing.

1991 • 139 citations

Smooth muscle releases an epithelial cell scatter factor which binds to heparin

1989 • 136 citations

Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.

1992 • 136 citations

New Method for Detecting Cellular Transforming Genes

1982 • 131 citations

Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable

1991 • 129 citations

Identification and change in the receptor for hepatocyte growth factor in rat liver after partial hepatectomy or induced hepatitis

1991 • 123 citations

Growth factors as transforming proteins

1989 • 122 citations

Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene.

1990 • 119 citations

Characterization of the mouse met proto-oncogene.

1988 • 108 citations

Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor

1991 • 81 citations

p145, a Protein with Associated Tyrosine Kinase Activity in a Human Gastric Carcinoma Cell Line

1988 • 81 citations

The isolation and preliminary characterization of temperature-sensitive transformation mutants of Moloney sarcoma virus

1979 • 76 citations

Post-translational acquisition of insulin binding activity by the insulin proreceptor. Correlation to recognition by autoimmune antibody.

1987 • 73 citations

Tissue Distribution of Hepatocyte Growth Factor Receptor and Its Exclusive Down-Regulation in a Regenerating Organ after Injury1

1992 • 72 citations

Smooth muscle-derived factor stimulates mobility of human tumor cells.

1990 • 70 citations

Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts.

1986 • 61 citations

C-Terminal Truncated Forms of Met, the Hepatocyte Growth Factor Receptor

1991 • 52 citations

p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line.

1988 • 49 citations

Evidence for non-covalent clusters of the c-met proto-oncogene product.

1992 • 48 citations

Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences.

1988 • 37 citations

Characterization of an insulin receptor mutant lacking the subunit processing site.

1990 • 31 citations

Selection for transformation and met protooncogene amplification in NIH 3T3 fibroblasts using tumor necrosis factor alpha.

1990 • 19 citations

A Close-Up Look at a Secret Soviet Radar

1987 • 10 citations

Growth factors as transforming proteins

1989 • 1 citations