Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

1996 • 1,303 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Toward a molecular understanding of skeletal development

1995 • 683 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

1996 • 471 citations

Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation.

1994 • 455 citations

Type x collagen synthesis in human osteoarthritic cartilage. indication of chondrocyte hypertrophy

1992 • 445 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

A human chondrodysplasia due to a mutation in a TGF-β superfamily member

1996 • 412 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family

1996 • 387 citations

Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint.

1994 • 354 citations

Chondrocyte Differentiation

1995 • 330 citations

The Biology of Osteoarthritis

1989 • 326 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2

1990 • 325 citations

Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development

1997 • 308 citations

What do BMPs do in mammals? Clues from the mouse short-ear mutation

1994 • 300 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta.

1990 • 264 citations

Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors.

1988 • 261 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts

1987 • 255 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

TGF-β1 Prevents Hypertrophy of Epiphyseal Chondrocytes: Regulation of Gene Expression for Cartilage Matrix Proteins and Metalloproteases

1993 • 240 citations

TGF‐β Receptors and TGF‐β Binding Proteoglycans: Recent Progress in Identifying Their Functional Properties

1990 • 233 citations

BMP7 Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye

1997 • 230 citations

Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-β and evidence for endogenous TGF-β-like activity

1991 • 229 citations

Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.

1991 • 226 citations

Regulation of differentiation by TFG-β

1996 • 223 citations

Growth factor actions on articular cartilage.

1995 • 209 citations

Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-β1

1995 • 205 citations

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.

1991 • 198 citations

Enhanced expression of TGF-β and c-fos mRNAs in the growth plates of developing human long bones

1988 • 173 citations

Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-β

1989 • 166 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?

1994 • 145 citations

Inhibition of Capillary Morphogenesis and Associated Apoptosis by Dominant Negative Mutant Transforming Growth Factor-β Receptors

1995 • 142 citations

Expression of TGF-β isoforms during first trimester human embryogenesis

1990 • 139 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Transforming growth factor-β in calf articular cartilage organ cultures: Synthesis and distribution

1991 • 124 citations

Terminal Differentiation of Chondrocytes in Culture Is a Spontaneous Process and Is Arrested by Transforming Growth Factor-β2 and Basic Fibroblast Growth Factor in Synergy

1995 • 109 citations

Peptide growth factors and their interactions during chondrogenesis

1992 • 85 citations

Studies on the morphogenesis of the mouse sternum. I. Normal embryonic development.

1952 • 81 citations

Bone growth: Coordinating chondrocyte differentiation

1996 • 79 citations

Growth factors — from genes to clinical application

1990 • 76 citations

Muscle fatigue in early fibromyalgia.

1995 • 76 citations

Opposite effects of osteogenic protein and transforming growth factor β on chondrogenesis in cultured long bone rudiments

1994 • 67 citations

Induction of swelling, synovial hyperplasia and cartilage proteoglycan loss upon intra-articular injection of transforming growth factor β-2 in the rabbit

1992 • 67 citations

OSTEOARTHRITIC HUMAN CARTILAGE IS MORE SENSITIVE TO TRANSFORMING GROWTH FACTOR THAN IS NORMAL CARTILAGE

1993 • 63 citations

Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serum-free agarose culture.

1993 • 47 citations

Expression of parathyroid hormone-related protein in rat articular cartilage

1995 • 45 citations

Complete congenital sternal cleft in an adult: Repair by autogenous tissues

1996 • 42 citations

Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors.

1994 • 39 citations

A Rapid Method for Preparing High Quality Alizarin Stained Skeletons of Adult Mice

1987 • 38 citations

Growth factors in experimental osteoarthritis: transforming growth factor beta pathogenic?

1995 • 35 citations

Tumoral calcinosis of the cervical spine in an infant

1997 • 29 citations

Retinoic acid-induced stress protein synthesis in the mouse

1995 • 21 citations

Molecular Analysis of TGFβ Signal Transduction

1995 • 2 citations