A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Lifetime Risk for Diabetes Mellitus in the United States

2003 • 1,545 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

2002 • 1,500 citations

Histone and chromatin cross-talk

2003 • 1,187 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes

2004 • 1,032 citations

In vitro cultivation of human islets from expanded ductal tissue

2000 • 972 citations

Developmental biology of the pancreas

1995 • 942 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

2000 • 741 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 534 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster

1998 • 481 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 460 citations

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

2003 • 446 citations

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

1997 • 443 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Regulation of pancreas development by hedgehog signaling

2000 • 415 citations

Intercellular signals regulating pancreas development and function

2001 • 399 citations

Regulation of RNA Polymerase II Transcription by Sequence-Specific DNA Binding Factors

2004 • 393 citations

Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion

2002 • 379 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.

1996 • 328 citations

Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.

1999 • 326 citations

Increased islet apoptosis in Pdx1+/– mice

2003 • 319 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

The pancreatic ductal epithelium serves as a potential pool of progenitor cells

2004 • 309 citations

Tails of Intrigue

2003 • 305 citations

Increased islet apoptosis in Pdx1+/– mice

2003 • 304 citations

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration

2007 • 292 citations

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

1999 • 285 citations

Quantitative Assessment of Gene Targeting in Vitroand in Vivo by the Pancreatic Transcription Factor, Pdx1

2002 • 282 citations

Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.

1996 • 279 citations

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

2002 • 269 citations

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

1999 • 258 citations

Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

2006 • 255 citations

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

2004 • 251 citations

Experimental control of pancreatic development and maintenance

2002 • 231 citations

Stabilization of β-catenin impacts pancreas growth

2006 • 221 citations

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells

1999 • 219 citations

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

1996 • 218 citations

PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells

2003 • 215 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

1994 • 205 citations

Palmitate Inhibits Insulin Gene Expression by Altering PDX-1 Nuclear Localization and Reducing MafA Expression in Isolated Rat Islets of Langerhans

2005 • 205 citations

PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin

1996 • 202 citations

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

2002 • 199 citations

Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro

2000 • 198 citations

Genetic Regulation of Metabolic Pathways in β-Cells Disrupted by Hyperglycemia

2002 • 198 citations

The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter

2000 • 194 citations

PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance

2005 • 185 citations

The Islet β Cell-enriched MafA Activator Is a Key Regulator of Insulin Gene Transcription

2005 • 183 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

1993 • 183 citations

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

2006 • 182 citations

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

1996 • 180 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 179 citations

Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47

2002 • 178 citations

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.

1998 • 173 citations

An Endocrine-Exocrine Switch in the Activity of the Pancreatic Homeodomain Protein PDX1 through Formation of a Trimeric Complex with PBX1b and MRG1 (MEIS2)

1998 • 170 citations

Agenesis of Human Pancreas due to Decreased Half-Life of Insulin Promoter Factor 1

2003 • 169 citations

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

2001 • 166 citations

Mechanisms of Compensatory β-Cell Growth in Insulin-Resistant Rats

2005 • 165 citations

The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 β-cells

2003 • 161 citations

Pancreatic β Cell-specific Transcription of thepdx-1 Gene

2000 • 161 citations

Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of β-Cells in the Adult Pancreas

2005 • 160 citations

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

2005 • 157 citations

Regulation of Insulin Gene Transcription by ERK1 and ERK2 in Pancreatic β Cells

2003 • 154 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 152 citations

Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time

2003 • 152 citations

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

2006 • 152 citations

The Pancreatic Islet Factor STF-1 Binds Cooperatively with Pbx to a Regulatory Element in the Somatostatin Promoter: Importance of the FPWMK Motif and of the Homeodomain

1995 • 152 citations

Hedgehog signaling in pancreas development

2002 • 151 citations

Hedgehog signaling regulation of insulin production by pancreatic beta-cells.

2000 • 151 citations

Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation

2006 • 149 citations

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

1994 • 141 citations

Proendocrine genes coordinate the pancreatic islet differentiation program in vitro

2004 • 140 citations

Conservation of PDX-1 Structure, Function, and Expression in Zebrafish*

1998 • 133 citations

Transcription Factor BETA2 Acts Cooperatively with E2A and PDX1 to Activate the Insulin Gene Promoter

2000 • 128 citations

Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse

2006 • 128 citations

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

2001 • 123 citations

Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning

1996 • 122 citations

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

1998 • 121 citations

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression

2000 • 120 citations

Transcription factors direct the development and function of pancreatic β cells

2003 • 119 citations

FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start Site

2006 • 119 citations

High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells

2004 • 119 citations

The Role of Hepatic Nuclear Factor 1α and PDX-1 in Transcriptional Regulation of the pdx-1 Gene

2001 • 118 citations

Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic α- and β-Cells

1991 • 116 citations

Mechanism of insulin Gene Regulation by the Pancreatic Transcription Factor Pdx-1

2005 • 114 citations

Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1

2001 • 114 citations

Glucose-stimulated Preproinsulin Gene Expression and Nucleartrans-Location of Pancreatic Duodenum Homeobox-1 Require Activation of Phosphatidylinositol 3-Kinase but Not p38 MAPK/SAPK2

2000 • 112 citations

Glucose Regulation of Insulin Gene Expression Requires the Recruitment of p300 by the β-Cell-Specific Transcription Factor Pdx-1

2004 • 111 citations

Regulatory Regions Driving Developmental and Tissue-Specific Expression of the Essential Pancreatic Gene pdx1

2001 • 109 citations

The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas

2005 • 109 citations

Phosphorylation Marks IPF1/PDX1 Protein for Degradation by Glycogen Synthase Kinase 3-dependent Mechanisms

2006 • 107 citations

Glucose Regulates Insulin Gene Transcription by Hyperacetylation of Histone H4

2003 • 100 citations

Mosaic Cre-mediated recombination in pancreas using thepdx-1 enhancer/promoter

2000 • 100 citations

PDX-1 and Msx-2 expression in the regenerating and developing pancreas

1999 • 98 citations

Hedgehog signaling regulates expansion of pancreatic epithelial cells

2005 • 97 citations

Involvement of the Homeodomain-Containing Transcription Factor PDX-1 in Islet Amyloid Polypeptide Gene Transcription

1996 • 96 citations

Exendin‐4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX‐1 and HNF3β transcription factors

2002 • 96 citations

Functional Characterization of the Transactivation Properties of the PDX-1 Homeodomain Protein

1997 • 96 citations

A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer.

1988 • 95 citations

Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation

2003 • 94 citations

Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell

2001 • 93 citations

The Pancreatic Duodenal Homeobox-1 Protein (Pdx-1) Interacts with Histone Deacetylases Hdac-1 and Hdac-2 on Low Levels of Glucose

2004 • 92 citations

Pdx-1 Links Histone H3-Lys-4 Methylation to RNA Polymerase II Elongation during Activation of Insulin Transcription

2005 • 92 citations

Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX‐1

1999 • 91 citations

Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development

2003 • 90 citations

Relative contribution of PDX-1, MafA and E47/β2 to the regulation of the human insulin promoter

2005 • 90 citations

Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets

2007 • 87 citations

Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-Wide Pdx1 Expression

2007 • 85 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1

1994 • 84 citations

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

2004 • 84 citations

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.

1999 • 83 citations

Transcription Factor Occupancy of the Insulin Gene in Vivo

2003 • 82 citations

Glucose stimulates the activation domain potential of the PDX‐1 homeodomain transcription factor

1998 • 79 citations

Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic β Cells: Role for Hepatocyte Nuclear Factor 3β and Pax6

2002 • 79 citations

DNA Binding and Transcriptional Activation by a PDX1·PBX1b·MEIS2b Trimer and Cooperation with a Pancreas-specific Basic Helix-Loop-Helix Complex

2001 • 78 citations

IPF1/PDX1 Deficiency and β-Cell Dysfunction in Psammomys obesus, an Animal With Type 2 Diabetes

2001 • 78 citations

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

2001 • 77 citations

Autoregulation and Maturity Onset Diabetes of the Young Transcription Factors Control the Human PAX4 Promoter

2000 • 76 citations

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells

2005 • 76 citations

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

2000 • 75 citations

Conserved Transcriptional Regulatory Domains of the pdx-1 Gene

2004 • 73 citations

SOX6 Attenuates Glucose-stimulated Insulin Secretion by Repressing PDX1 Transcriptional Actvity and Is Down-regulated in Hyperinsulinemic Obese Mice

2005 • 73 citations

Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells derived from mouse embryonic stem cells

2005 • 71 citations

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic β-cells

2001 • 71 citations

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

2001 • 71 citations

Glucose Regulates Islet Amyloid Polypeptide Gene Transcription in a PDX1- and Calcium-dependent Manner

2000 • 69 citations

Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.

2000 • 67 citations

Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic β-Cells*

2001 • 64 citations

Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional Activity

2004 • 63 citations

Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase

2005 • 61 citations

Improved Glucose Tolerance and Acinar Dysmorphogenesis by Targeted Expression of Transcription Factor PDX-1 to the Exocrine Pancreas

2001 • 60 citations

Mechanism of PDX-1 protein transduction

2005 • 60 citations

Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene.

1996 • 59 citations

Pancreas Duodenum Homeobox-1 Transcriptional Activation Requires Interactions with p300

2004 • 58 citations

The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

1996 • 57 citations

The Transcriptional Repressor Nkx6.1 Also Functions as a Deoxyribonucleic Acid Context-Dependent Transcriptional Activator during Pancreatic β-Cell Differentiation: Evidence for Feedback Activation of thenkx6.1Gene by Nkx6.1

2004 • 55 citations

Regulation of the Pancreatic Duodenal Homeobox-1 Protein by DNA-dependent Protein Kinase

2005 • 50 citations

Cell-Specific Expression of Glucose-Dependent-Insulinotropic Polypeptide Is Regulated by the Transcription Factor PDX-1

2004 • 50 citations

Diabetes Outfoxed by GLP-1?

2005 • 48 citations

Expression of the Intermediate Filament Vimentin in Proliferating Duct Cells as a Marker of Pancreatic Precursor Cells

2004 • 48 citations

Induction of PDX‐1‐positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats

2002 • 47 citations

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor

1994 • 43 citations

PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin

1996 • 43 citations

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

2001 • 38 citations

Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis

1997 • 38 citations

The PDX1 Homeodomain Transcription Factor Negatively Regulates the Pancreatic Ductal Cell-specific Keratin 19 Promoter

2006 • 35 citations

Identification of a Novel PDX-1 Binding Site in the Human Insulin Gene Enhancer

2004 • 34 citations

Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3This paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

2006 • 33 citations

Conservation of PDX-1 Structure, Function, and Expression in Zebrafish

1998 • 33 citations

Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression

2006 • 31 citations

Glucagon-Like Peptide-1 Differentiation of Primate Embryonic Stem Cells into Insulin-Producing Cells

2006 • 31 citations

Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1

2004 • 31 citations

Structural Basis for Induced Fit Mechanisms in DNA Recognition by the Pdx1 Homeodomain^,

2007 • 31 citations

Insulin stimulates pancreatic‒duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic β cells

1999 • 30 citations

Pdx‐1 knockdown reduces insulin promoter activity in zebrafish

2001 • 29 citations

The coactivator Bridge-1 increases transcriptional activation by pancreas duodenum homeobox-1 (PDX-1)

2005 • 28 citations

Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic β-cells

2006 • 27 citations

Interactions between Areas I and II Direct pdx-1 Expression Specifically to Islet Cell Types of the Mature and Developing Pancreas

2005 • 27 citations

Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene

1996 • 24 citations

Two proteins act as the IUF1 insulin gene enhancer binding factor

1991 • 24 citations

Role of Chromatin Accessibility in the Occupancy and Transcription of the Insulin Gene by the Pancreatic and Duodenal Homeobox Factor 1

2006 • 22 citations

Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets

2005 • 17 citations

The C-Terminal Domain of the β Cell Homeodomain Factor Nkx6.1 Enhances Sequence-Selective DNA Binding at the insulin Promoter

2005 • 17 citations

Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic -Cells

2001 • 17 citations

Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1

2005 • 17 citations