FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start Site

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

2004 • 1,293 citations

A Highly Efficient Escherichia coli-Based Chromosome Engineering System Adapted for Recombinogenic Targeting and Subcloning of BAC DNA

2001 • 1,194 citations

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

VISTA : visualizing global DNA sequence alignments of arbitrary length

2000 • 957 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

2000 • 895 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1997 • 776 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

1999 • 610 citations

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

1995 • 601 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

2005 • 541 citations

MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion

2005 • 457 citations

Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development

2004 • 442 citations

Gene regulatory factors in pancreatic development

2003 • 378 citations

Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms

1999 • 312 citations

Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA

2002 • 304 citations

MafA Is a Glucose-regulated and Pancreatic β-Cell-specific Transcriptional Activator for the Insulin Gene

2002 • 294 citations

Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells

2003 • 291 citations

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

2004 • 269 citations

A transcription factor regulatory circuit in differentiated pancreatic cells

2001 • 250 citations

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

1994 • 207 citations

MafB

2006 • 196 citations

A Rapid, Sensitive, and Inexpensive Assay for Chloramphenicol Acetyltransferase

1987 • 196 citations

Pancreatic β Cell-specific Transcription of thepdx-1 Gene

2000 • 161 citations

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

2005 • 157 citations

Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas.

1994 • 151 citations

Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes

2004 • 147 citations

PAX6 Mutation as a Genetic Factor Common to Aniridia and Glucose Intolerance

2002 • 142 citations

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

1994 • 141 citations

Rat Endocrine Pancreatic Development in Relation to Two Homeobox Gene Products (Pdx-1 and Nkx 6.1)

1998 • 120 citations

The Role of Hepatic Nuclear Factor 1α and PDX-1 in Transcriptional Regulation of the pdx-1 Gene

2001 • 118 citations

Regulation of insulin gene transcription

2000 • 117 citations

Sequences within the 5′-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes

1989 • 115 citations

Conserved elements in Pax6 intron 7 involved in (auto)regulation and alternative transcription

2003 • 114 citations

Concerted evolution of human amylase genes.

1988 • 112 citations

Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas

2002 • 95 citations

A Genetic Switch in Pancreatic β-Cells

2002 • 87 citations

Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic β Cells: Role for Hepatocyte Nuclear Factor 3β and Pax6

2002 • 79 citations

An Adenovirus Vector for Efficient RNA Interference–Mediated Suppression of Target Genes in Insulinoma Cells and Pancreatic Islets of Langerhans

2004 • 73 citations

Conserved Transcriptional Regulatory Domains of the pdx-1 Gene

2004 • 73 citations

Comparison of maf gene expression patterns during chick embryo development

2003 • 63 citations

The Islet ॆ Cell-enriched RIPE3b1/Maf Transcription Factor Regulates pdx-1 Expression

2003 • 59 citations

Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter

2003 • 58 citations

Concerted Evolution of Human Amylase Genes

1988 • 36 citations

Identification of a Novel PDX-1 Binding Site in the Human Insulin Gene Enhancer

2004 • 34 citations

Interactions between Areas I and II Direct pdx-1 Expression Specifically to Islet Cell Types of the Mature and Developing Pancreas

2005 • 27 citations