Regulation of the Pancreatic Duodenal Homeobox-1 Protein by DNA-dependent Protein Kinase

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

Mechanism and regulation of human non-homologous DNA end-joining

2003 • 957 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

The DNA-dependent protein kinase

1999 • 896 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

1997 • 445 citations

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

1998 • 435 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Ku70 suppresses the apoptotic translocation of Bax to mitochondria

2003 • 358 citations

Regulation of insulin gene transcription

2002 • 354 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

A practical approach to crosslinking

1993 • 276 citations

Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines.

1999 • 237 citations

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells

1999 • 219 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

1994 • 205 citations

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

2003 • 202 citations

An Endocrine-Exocrine Switch in the Activity of the Pancreatic Homeodomain Protein PDX1 through Formation of a Trimeric Complex with PBX1b and MRG1 (MEIS2)

1998 • 170 citations

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

1994 • 168 citations

XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm

1989 • 162 citations

Regulation of Insulin Gene Transcription by ERK1 and ERK2 in Pancreatic β Cells

2003 • 154 citations

The Pancreatic Islet Factor STF-1 Binds Cooperatively with Pbx to a Regulatory Element in the Somatostatin Promoter: Importance of the FPWMK Motif and of the Homeodomain

1995 • 152 citations

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat

1998 • 149 citations

DNA-Dependent Protein Kinase Phosphorylation Sites in Ku 70/80 Heterodimer

1999 • 135 citations

Sites of UV-induced Phosphorylation of the p34 Subunit of Replication Protein A from HeLa Cells

1997 • 133 citations

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

2000 • 125 citations

Interferon regulatory factor-3 is an in vivo target of DNA-PK

2002 • 120 citations

Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1

2001 • 114 citations

A myogenic differentiation checkpoint activated by genotoxic stress

2002 • 113 citations

c-Jun is phosphorylated by the DNA-dependent protein kinasein vitro; definition of the minimal kinase recognition motif

1993 • 104 citations

Oxidative Stress Induces Nuclear Loss of DNA Repair Proteins Ku70 and Ku80 and Apoptosis in Pancreatic Acinar AR42J Cells

2003 • 100 citations

The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site

1995 • 91 citations

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

2000 • 75 citations

Regulation of pdx-1 Gene Expression

2002 • 73 citations

DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties

1998 • 72 citations

Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

2004 • 68 citations

The Binding of Ku Antigen to Homeodomain Proteins Promotes Their Phosphorylation by DNA-dependent Protein Kinase

2001 • 63 citations

Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1.

2003 • 45 citations