Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

Cell Death

2004 • 4,599 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

β-Cell death during progression to diabetes

2001 • 883 citations

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

2005 • 541 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 515 citations

MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion

2005 • 457 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

2002 • 370 citations

Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA

2002 • 304 citations

Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

1999 • 276 citations

Knockout mice: simple solutions to the problems of genetic background and flanking genes

2002 • 272 citations

RIP-Cre Revisited, Evidence for Impairments of Pancreatic β-Cell Function

2005 • 238 citations

Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass

2006 • 220 citations

Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production

2003 • 207 citations

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor

2002 • 188 citations

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

2004 • 179 citations

Lilly Lecture 2003

2004 • 169 citations

Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells

2000 • 164 citations

Hepatocyte Nuclear Factor-4α Is Essential for Glucose-stimulated Insulin Secretion by Pancreatic β-Cells

2005 • 160 citations

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor

2002 • 157 citations

Melanin-Concentrating Hormone Receptor Is a Target of Leptin Action in the Mouse Brain

2001 • 132 citations

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

2003 • 118 citations

Metabolic Oscillations in β-Cells

2002 • 107 citations

New Insights into the Roles of Insulin/IGF-I in the Development and Maintenance of β-Cell Mass

2005 • 95 citations

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

2004 • 84 citations

Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and β-Cell Compensation to Insulin Resistance

2002 • 74 citations

Pharmacological Properties and Functional Role of Kslow Current in Mouse Pancreatic β-Cells

2005 • 67 citations

Calcium-activated K+ Channels of Mouse β-cells are Controlled by Both Store and Cytoplasmic Ca2+

2002 • 64 citations