The Pancreatic Islet Factor STF-1 Binds Cooperatively with Pbx to a Regulatory Element in the Somatostatin Promoter: Importance of the FPWMK Motif and of the Homeodomain

Homeobox genes and axial patterning

1992 • 2,688 citations

Hox genes in vertebrate development

1994 • 2,057 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

Transcriptional regulation

1991 • 893 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

1995 • 396 citations

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

1992 • 396 citations

The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein

1994 • 378 citations

What determines the specificity of action of Drosophila homeodomain proteins?

1990 • 357 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

1991 • 280 citations

extradenticle Raises the DNA binding specificity of homeotic selector gene products

1994 • 269 citations

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1

1993 • 264 citations

Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

1990 • 239 citations

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

1991 • 237 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

1994 • 205 citations

Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.

1994 • 157 citations

Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity

1993 • 142 citations

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

1994 • 141 citations

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.

1994 • 123 citations

PBX2 and PBX3, New Homeobox Genes with Extensive Homology to the Human Proto-Oncogene PBX1

1991 • 108 citations

Functional specificity of the Antennapedia homeodomain.

1993 • 89 citations

37 A Combinatorial Regulatory Circuit in Budding Yeast

1992 • 53 citations

Fusion with E2A Converts the Pbx1 Homeodomain Protein into a Constitutive Transcriptional Activator in Human Leukemias Carrying the t(1;19) Translocation

1994 • 37 citations