Interactions between Areas I and II Direct pdx-1 Expression Specifically to Islet Cell Types of the Mature and Developing Pancreas

Handbook of Physiology.

1960 • 10,428 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

1995 • 601 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA

2002 • 304 citations

MafA Is a Glucose-regulated and Pancreatic β-Cell-specific Transcriptional Activator for the Insulin Gene

2002 • 294 citations

Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells

2003 • 291 citations

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

1997 • 256 citations

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function

2001 • 255 citations

Discrete elements within the SV40 enhancer region display different cell-specific enhancer activities.

1987 • 240 citations

Transcriptional networks controlling pancreatic development and beta cell function

2004 • 218 citations

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

1994 • 207 citations

Pancreatic β Cell-specific Transcription of thepdx-1 Gene

2000 • 161 citations

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

1994 • 141 citations

Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.

1989 • 123 citations

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression

2000 • 120 citations

The Role of Hepatic Nuclear Factor 1α and PDX-1 in Transcriptional Regulation of the pdx-1 Gene

2001 • 118 citations

Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1

1999 • 116 citations

Regulatory Regions Driving Developmental and Tissue-Specific Expression of the Essential Pancreatic Gene pdx1

2001 • 109 citations

A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription Factors

2001 • 107 citations

Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins

2000 • 102 citations

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell Function

2004 • 100 citations

Identification of a Pancreatic β-Cell Insulin Gene Transcription Factor That Binds to and Appears To Activate Cell-Type-Specific Expression: Its Possible Relationship to Other Cellular Factors That Bind to a Common Insulin Gene Sequence

1990 • 94 citations

Selective expression of rat pancreatic genes during embryonic development.

1986 • 89 citations

Pancreatic Islet Expression of the Homeobox Factor STF-1 Relies on an E-box Motif That Binds USF

1996 • 88 citations

Transcription Factor Occupancy of the Insulin Gene in Vivo

2003 • 82 citations

Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic β Cells: Role for Hepatocyte Nuclear Factor 3β and Pax6

2002 • 79 citations

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

2000 • 75 citations

Conserved Transcriptional Regulatory Domains of the pdx-1 Gene

2004 • 73 citations

The Islet ॆ Cell-enriched RIPE3b1/Maf Transcription Factor Regulates pdx-1 Expression

2003 • 59 citations

The RIPE3b1 Activator of the Insulin Gene Is Composed of a Protein(s) of Approximately 43 kDa, Whose DNA Binding Activity Is Inhibited by Protein Phosphatase Treatment

2000 • 40 citations