Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

2004 • 2,188 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

2003 • 708 citations

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

1999 • 693 citations

A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development

1993 • 650 citations

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

2002 • 616 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 534 citations

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

2000 • 519 citations

Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

2001 • 509 citations

β cell replication is the primary mechanism for maintaining postnatal β cell mass

2004 • 488 citations

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

2005 • 485 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 460 citations

Very Slow Turnover of β-Cells in Aged Adult Mice

2005 • 456 citations

Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats

1995 • 435 citations

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat*

1997 • 399 citations

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2001 • 381 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Islet growth and development in the adult

2000 • 338 citations

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2001 • 328 citations

Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

2005 • 328 citations

Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice

1993 • 325 citations

Increased islet apoptosis in Pdx1+/– mice

2003 • 319 citations

Increased islet apoptosis in Pdx1+/– mice

2003 • 304 citations

ISOLATION OF RAT PANCREATIC ISLETS BY DUCTAL INJECTION OF COLLAGENASE1

1986 • 256 citations

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

1997 • 256 citations

Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

2006 • 255 citations

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

2004 • 251 citations

Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass

2006 • 220 citations

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

2004 • 215 citations

Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity

2006 • 198 citations

A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

1993 • 191 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 179 citations

Mechanisms of Compensatory β-Cell Growth in Insulin-Resistant Rats

2005 • 165 citations

Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

2004 • 162 citations

β-Cell Neogenesis During Prolonged Hyperglycemia in Rats

2002 • 160 citations

Endocrine pancreas plasticity under physiological and pathological conditions.

2001 • 155 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 152 citations

Insulin Receptor Substrate-2 Proteasomal Degradation Mediated by a Mammalian Target of Rapamycin (mTOR)-induced Negative Feedback Down-regulates Protein Kinase B-mediated Signaling Pathway in β-Cells

2004 • 143 citations

Regeneration of Pancreatic Islets After Partial Pancreatectomy in Mice Does Not Involve the Reactivation of Neurogenin-3

2006 • 114 citations

Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function

2005 • 80 citations

Models of pancreatic regeneration in diabetes

2002 • 56 citations

Effect of partial pancreatectomy on diabetic status in BALB/c mice

1999 • 54 citations

Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function

2006 • 54 citations

Compensatory Adaption to Partial Pancreatectomy in the Rat*

1989 • 53 citations

Review: Pancreatic β‐Cell Neogenesis Revisited

2004 • 48 citations

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats

2001 • 45 citations

Mechanisms of glucose hypersensitivity in beta-cells from normoglycemic, partially pancreatectomized mice.

1999 • 36 citations

Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin

2002 • 20 citations

Islet neogenesis is stimulated by brief occlusion of the main pancreatic duct

2004 • 4 citations