Cell-Specific Expression of Glucose-Dependent-Insulinotropic Polypeptide Is Regulated by the Transcription Factor PDX-1

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

2002 • 887 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 845 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 727 citations

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1997 • 690 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 534 citations

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.

1988 • 518 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 460 citations

Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

2002 • 458 citations

The LIM domain is a modular protein-binding interface

1994 • 450 citations

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

1992 • 396 citations

Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion

2002 • 379 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence

1971 • 323 citations

Glucose-Dependent Insulin Release from Genetically Engineered K Cells

2000 • 293 citations

Transcribing pancreas.

1998 • 252 citations

Gastric Inhibitory Polypeptide: Its Physiologic Release and Insulinotropic Action in the Dog

1975 • 242 citations

Gastric Inhibitory Polypeptide (GIP) Stimulation by Oral Glucose in Man

1974 • 227 citations

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

1994 • 205 citations

The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter

2000 • 194 citations

Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) im man

1978 • 192 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

1993 • 183 citations

Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat.

1996 • 149 citations

Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for Type 2-diabetes

2009 • 142 citations

Effects of the novel (Pro3)GIP antagonist and exendin(9–39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

2003 • 130 citations

A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus.

1998 • 129 citations

Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning

1996 • 122 citations

The Role of Hepatic Nuclear Factor 1α and PDX-1 in Transcriptional Regulation of the pdx-1 Gene

2001 • 118 citations

Identification of the intestinal cell storing gastric inhibitory peptide

1975 • 110 citations

The LIM Domain Homeobox Gene isl-1 Is a Positive Regulator of Islet Cell-specific Proglucagon Gene Transcription

1995 • 110 citations

Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.

1987 • 106 citations

Functional Characterization of the Transactivation Properties of the PDX-1 Homeodomain Protein

1997 • 96 citations

Gastric Inhibitory Polypeptide: Structure and Chromosomal Localization of the Human Gene

1989 • 85 citations

IPF1, a homeodomain protein with a dual function in pancreas development.

1995 • 84 citations

Transcription Factor Occupancy of the Insulin Gene in Vivo

2003 • 82 citations

Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and alpha-CBF-like transcription factors.

1992 • 76 citations

Glucose-dependent insulinotropic peptide: structure of the precursor and tissue-specific expression in rat.

1993 • 68 citations

Glucose Rapidly and Reversibly Decreases INS-1 Cell Insulin Gene Transcription via Decrements in STF-1 and C1 Activator Transcription Factor Activity

1998 • 60 citations

Release of gastric inhibitory polypeptide from cultured canine endocrine cells

1994 • 48 citations

Effects of antibodies to gastric inhibitory peptide on gastric acid secretion and gastrin release in the dog

1983 • 39 citations

Activation of amylin gene transcription by LIM domain homeobox gene isl-1.

1996 • 38 citations

Expression of liver fatty acid-binding protein/human growth hormone fusion genes within the enterocyte and enteroendocrine cell populations of fetal transgenic mice.

1991 • 35 citations

Cell-specific Expression of the Glucose-dependent Insulinotropic Polypeptide Gene in a Mouse Neuroendocrine Tumor Cell Line

1997 • 35 citations

Isolation and Characterization of the Gene Encoding Rat Glucose-Dependent Insulinotropic Peptide

1993 • 24 citations

Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene functions through a GATA and an ISL-1 motif in a mouse neuroendocrine tumor cell line

2003 • 22 citations

Diabetes mellitus : methods and protocols

2003 • 5 citations