Matrix metalloproteinases in tumor–host cell communication

The Hallmarks of Cancer

2000 • 27,569 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Matrix metalloproteinases: they're not just for matrix anymore!

2001 • 1,257 citations

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

1997 • 1,227 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Anoikis mechanisms

2001 • 1,172 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Matrix metalloproteinases: a tail of a frog that became a prince

2002 • 1,082 citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

2001 • 993 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

1999 • 699 citations

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 • 685 citations

The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

1999 • 679 citations

The biology of cell locomotion within three-dimensional extracellular matrix

2000 • 647 citations

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

1997 • 633 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin

2000 • 491 citations

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

2002 • 472 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 449 citations

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

1998 • 446 citations

Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

1997 • 434 citations

Angiostatin-converting Enzyme Activities of Human Matrilysin (MMP-7) and Gelatinase B/Type IV Collagenase (MMP-9)

1997 • 430 citations

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-β1 release

1997 • 428 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

The Natural History of Herniated Nucleus Pulposus With Radiculopathy

1996 • 411 citations

The influence of the microenvironment on the malignant phenotype

2000 • 398 citations

Osteopontin, a Novel Substrate for Matrix Metalloproteinase-3 (Stromelysin-1) and Matrix Metalloproteinase-7 (Matrilysin)

2001 • 394 citations

Matrix metalloproteinases and TIMPs

2000 • 379 citations

Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.

2001 • 365 citations

Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption

2000 • 357 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165

2002 • 348 citations

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

1994 • 345 citations

Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells

1997 • 341 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

1996 • 331 citations

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site

1997 • 329 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 312 citations

Experimental metastasis is suppressed in MMP-9-deficient mice.

1999 • 300 citations

Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinomain situ

1997 • 299 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Adhesion events in angiogenesis

2001 • 286 citations

Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression

1995 • 281 citations

Cleavage of β-Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases

1998 • 264 citations

Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo

2000 • 264 citations

The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter

2000 • 255 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Defective E-cadherin/catenin complexes in human cancer

2001 • 250 citations

Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

2001 • 235 citations

Heparan Sulfate Proteoglycans as Extracellular Docking Molecules for Matrilysin (Matrix Metalloproteinase 7)

2000 • 234 citations

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

2002 • 222 citations

Extracellular Matrix Binding Properties of Recombinant Fibronectin Type II-like Modules of Human 72-kDa Gelatinase/Type IV Collagenase

1995 • 221 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Identification of Insulin-like Growth Factor-binding Protein-1 as a Potential Physiological Substrate for Human Stromelysin-3

1997 • 208 citations

Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.

1993 • 182 citations

Matrix metalloproteinase-3–dependent generation of a macrophage chemoattractant in a model of herniated disc resorption

2000 • 180 citations

Tumors are unique organs defined by abnormal signaling and context

2001 • 174 citations

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.

2000 • 172 citations

Specialized Surface Protrusions of Invasive Cells, Invadopodia and Lamellipodia, Have Differential MT1‐MMP, MMP‐2, and TIMP‐2 Localization

1999 • 163 citations

The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.

1998 • 162 citations

Matrilysin [MMP-7] Expression Selects for Cells with Reduced Sensitivity to Apoptosis

2001 • 159 citations

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

1995 • 158 citations

Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.

2002 • 157 citations

Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis

2002 • 151 citations

Collagenase Expression in Transgenic Mouse Skin Causes Hyperkeratosis and Acanthosis and Increases Susceptibility to Tumorigenesis

1995 • 141 citations

High Affinity Binding of Latent Matrix Metalloproteinase-9 to the α2(IV) Chain of Collagen IV

1998 • 138 citations

Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.

2001 • 137 citations

The role of osteopontin in breast cancer: clinical and experimental studies.

2001 • 132 citations

Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma

2001 • 130 citations

Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma.

1999 • 128 citations

Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts

2001 • 119 citations

Cleavage of β4 Integrin by Matrilysin

1997 • 115 citations

Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.

1995 • 114 citations

High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma

1996 • 107 citations

Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1

1999 • 106 citations

Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract.

1996 • 104 citations

The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells.

1995 • 102 citations

INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONS

1999 • 100 citations

Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells.

1996 • 93 citations

Evidence for endogenous proteases, mRNA level and insulin as multiple mechanisms of N-cadherin down-regulation during retinal development

1992 • 63 citations

MMPs Are IGFBP‐Degrading Proteinases: Implications for Cell Proliferation and Tissue Growth

1999 • 51 citations

Detection of regional lymph node metastases in colon cancer by using RT-PCR for matrix metalloproteinase 7, matrilysin.

1997 • 51 citations

Up-Regulated Expression of Matrilysin and Neutrophil Collagenase in Human Herniated Discs

1999 • 35 citations

Targeted disruption of CD44 in MDAY-D2 lymphosarcoma cells has no effect on subcutaneous growth or metastatic capacity.

1995 • 35 citations

Integrin- and Cadherin-Mediated Induction of the Matrix Metalloprotease Matrilysin in Cocultures of Malignant Oral Squamous Cell Carcinoma Cells and Dermal Fibroblasts

2001 • 32 citations

Up-Regulated Expression of Matrilysin and Neutrophil Collagenase in Human Herniated Discs

1999 • 17 citations

Pall Corp, USA

1999 • 2 citations