The influence of the microenvironment on the malignant phenotype

The Hallmarks of Cancer

2000 • 27,569 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

ECM signalling: orchestrating cell behaviour and misbehaviour

1998 • 537 citations

The multistep nature of cancer development.

1984 • 510 citations

Radiation carcinogenesis

2000 • 466 citations

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

1987 • 461 citations

The Influence of Extracellular Matrix on Gene Expression: Is Structure The Message?

1987 • 437 citations

Fibronectin and Its Integrin Receptors in Cancer

1999 • 338 citations

Cancer invasion and tissue remodeling‐cooperation of protease systems and cell types

1999 • 288 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Facts and theories concerning the mechanisms of carcinogenesis

1991 • 264 citations

Tissue structure, nuclear organization, and gene expression in normal and malignant breast.

1999 • 247 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium

1987 • 237 citations

Stromal Involvement In Malignant Growth

1988 • 225 citations

Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion

1998 • 209 citations

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

1981 • 208 citations

Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.

1998 • 189 citations

Estrogen responsiveness and control of normal human breast proliferation.

1998 • 187 citations

Cancer : a problem of developmental biology

1978 • 170 citations

Transforming growth factor-β in breast cancer: A working hypothesis

1997 • 154 citations

Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function.

1994 • 153 citations

Transforming growth factor ? regulation of cell proliferation

1987 • 152 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

1993 • 104 citations

The Tumor-Promoting Effect of Wounding: A Possible Role for TGF-β-lnduced Stromal Alterations

1994 • 100 citations

Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice.

1995 • 96 citations

Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor‐inducing effect of wounding in initiated nmri mouse skin

1989 • 83 citations

Nuclear Retinoid Acid Receptor Beta in Bronchial Epithelium of Smokers Before and During Chemoprevention

1999 • 82 citations

Elimination of transformed cells by normal cells: a novel concept for the control of carcinogenesis.

1996 • 74 citations

Modulation of Intercellular Communication during Radiation and Chemical Carcinogenesis

1990 • 69 citations

The potential influence of radiation-induced microenvironments in neoplastic progression.

1998 • 62 citations

Treatment of marrow stroma with interferon-alpha restores normal beta 1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors. Role of MIP-1 alpha.

1995 • 62 citations

Stromal Reaction to Invasive Cancer: The Cellular Origin of the Myofibroblast and Implications for Tumor Development

1996 • 14 citations

Role of host and tumor calcium in metastases.

1968 • 13 citations