Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

Matrix metalloproteinases and metastasis

1999 • 688 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

1998 • 446 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

Complex role of matrix metalloproteinases in angiogenesis

1998 • 311 citations

Integrin α1β1 Mediates a Unique Collagen-dependent Proliferation Pathway In Vivo

1998 • 299 citations

Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase

1999 • 282 citations

Inhibition of MMP Synthesis by Doxycycline and Chemically Modified Tetracyclines (CMTs) in Human Endothelial Cells

1998 • 223 citations

Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms

2000 • 215 citations

Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant.

2000 • 194 citations

Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme

1999 • 168 citations

Absence of integrin α1β1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis

1999 • 159 citations

MMP Inhibition in Prostate Cancer

1999 • 154 citations

Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis.

1998 • 139 citations

Physiological roles of matrix metalloproteinases: implications for tumor growth and metastasis

1999 • 136 citations

Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

2001 • 131 citations

Isolation and characterization of the circulating form of human endostatin

1997 • 115 citations

Expression of human macrophage metalloelastase gene in hepatocellular carcinoma: Correlation with angiostatin generation and its clinical significance

1998 • 84 citations

Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer: Differential Contributions of Perforin-Dependent Versus Fas-Mediated Pathways in Lysis by NK and T Cells

1998 • 83 citations

Inhibition of Matrix Metalloproteinase 9 Activation by a Specific Monoclonal Antibody

1993 • 70 citations

Tetracycline Derivatives Induce Apoptosis Selectively in Cultured Monocytes and Macrophages but not in Mesenchymal Cells

1998 • 65 citations

Simple and reliable method of doxycycline determination in human plasma and biological tissues

2000 • 50 citations

Inhibition of Tumor Angiogenesis^a

1994 • 45 citations

The antitumour effect of doxycycline on a T-cell leukaemia in the rat

1985 • 44 citations

Induction of persistent tumor-protective immunity in mice cured of established colon carcinoma metastases.

1998 • 33 citations

Suppression of Human Microvascular Endothelial Cell Invasion and Morphogenesis With Synthetic Matrixin Inhibitors

2000 • 27 citations

Effects of Doxycycline on Cancer Cells in Vitro and in Vivo

1998 • 20 citations

Pall Corp, USA

1999 • 2 citations