Sphingolipids as therapeutics

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind

2002 • 895 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Signal transduction of stress via ceramide

1998 • 687 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Sphingolipids in Food and the Emerging Importance of Sphingolipids to Nutrition

1999 • 563 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

1994 • 532 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

1995 • 469 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 394 citations

Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.

2001 • 376 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

1996 • 347 citations

De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells

2002 • 331 citations

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

2001 • 327 citations

Targeting Ceramide Metabolism--a Strategy for Overcoming Drug Resistance

2001 • 317 citations

Ceramide glycosylation potentiates cellular multidrug resistance

2001 • 303 citations

Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

1997 • 290 citations

Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines

1999 • 289 citations

Sphingosine‐1‐phosphate: signaling inside and out

2000 • 275 citations

First Human Trial of FTY720, a Novel Immunomodulator, in Stable Renal Transplant Patients

2002 • 272 citations

Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells

1999 • 269 citations

Lipids and barrier function of the skin

2000 • 266 citations

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

2002 • 265 citations

Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase

2000 • 237 citations

Sphingolipid functions in Saccharomyces cerevisiae

2002 • 237 citations

Ceramide-induced Inhibition of Akt Is Mediated through Protein Kinase Cζ

2002 • 236 citations

Ceramide Directly Activates Protein Kinase C ζ to Regulate a Stress-activated Protein Kinase Signaling Complex

2000 • 226 citations

Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

2000 • 219 citations

Epidermal sphingomyelins are precursors for selected stratum corneum ceramides

2000 • 208 citations

Colonic Cell Proliferation and Aberrant Crypt Foci Formation Are Inhibited by Dairy Glycosphingolipids in 1,2-Dimethylhydrazine-Treated CF1 Mice

2000 • 207 citations

FTY720: ALTERED LYMPHOCYTE TRAFFIC RESULTS IN ALLOGRAFT PROTECTION

2001 • 175 citations

Changes in the Lipid Turnover, Composition, and Organization, as Sphingolipid-enriched Membrane Domains, in Rat Cerebellar Granule Cells Developing in Vitro

2001 • 174 citations

Glucosylceramide: a marker for multiple-drug resistant cancers.

1998 • 172 citations

Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-α and ceramide

2000 • 165 citations

Sphingosine kinases: A novel family of lipid kinases

2002 • 158 citations

Ceramide as a second messenger: sticky solutions to sticky problems

2000 • 147 citations

Sphingosine-1-phosphate receptors and the development of the vascular system

2002 • 145 citations

TNF-α–Induced Tolerance to Ischemic Injury Involves Differential Control of NF-κB Transactivation: The Role of NF-κB Association with p300 Adaptor

2002 • 140 citations

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

2001 • 136 citations

Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.

2001 • 131 citations

Ceramide binds to the CaLB domain of cytosolic phospholipase A₂and facilitates its membrane docking and arachidonic acid release

2000 • 128 citations

Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.

1997 • 126 citations

Ceramide as an Activator Lipid of Cathepsin D

2006 • 125 citations

N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

2001 • 124 citations

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L‐positive T cells in Peyer’s patches by FTY720‐induced lymphocyte homing

1998 • 114 citations

A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin.

1997 • 103 citations

Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance

2001 • 96 citations

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of ras (KSR)

2002 • 89 citations

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes

1998 • 87 citations

Tamoxifen retards glycosphingolipid metabolism in human cancer cells

1996 • 87 citations

Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C

2002 • 85 citations

SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells.

1999 • 85 citations

Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics.

1999 • 84 citations

Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line

2000 • 72 citations

Glycosylation of Ceramide Potentiates Cellular Resistance to Tumor Necrosis Factor-α-Induced Apoptosis

1999 • 71 citations

Inhibitory actions of ceramide upon PKC-ε/ERK interactions

2001 • 65 citations

Role of glycosphingolipid microdomains in CD4-dependent HIV-1 fusion.

2000 • 64 citations

Inositol phosphoryl transferases from human pathogenic fungi

2000 • 64 citations

Ceramide-Coated Balloon Catheters Limit Neointimal Hyperplasia After Stretch Injury in Carotid Arteries

2000 • 61 citations

Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells.

2001 • 59 citations

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor

2002 • 56 citations

Ceramide mediates radiation-induced death of endothelium

2000 • 56 citations

Essential Roles of Carbohydrate Signals in Development, Immune Response and Tissue Functions, as Revealed by Gene Targeting

2000 • 54 citations

Cell Permeable Exogenous Ceramide Reduces Infarct Size in Spontaneously Hypertensive Rats Supporting In Vitro Studies That Have Implicated Ceramide in Induction of Tolerance to Ischemia

2001 • 52 citations

Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis

1998 • 44 citations

Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells

1999 • 31 citations

Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843

1998 • 30 citations

Impaired ceramide signalling in spontaneously hypertensive rat vascular smooth muscle: a possible mechanism for augmented cell proliferation

2001 • 26 citations

Myocardial and endothelial protection by TMS in ischemia-reperfusion injury

1995 • 23 citations

Molecular Cloning and Characterization of a Human cDNA and Gene Encoding a Novel Acid Ceramidase-like Protein

1999 • 17 citations